TNF Receptor-Associated Factor 5 (TRAF5) Human Recombinant Protein

Adapter protein and signal transducer that links mbers of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Ses to be involved in apoptosis. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR.

Cloning and characterization of a cDNA encoding the human homolog of tumor necrosis factor receptor-associated factor 5 (TRAF5) .Mizushima S., Fujita M., Ishida T., Azuma S., Kato K., Hirai M., Otsuka M., Yamamoto T., Inoue J.Gene 207:135-140(1998) Complete sequencing and characterization of 21,243 full-length human cDNAs.Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.Nat. Genet. 36:40-45(2004) Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Human TNF receptor-associated factor 5 (TRAF5) cDNA cloning, expression and assignment of the TRAF5 gene to chromosome 1q32.Nakano H., Shindo M., Yamada K., Yoshida M.C., Santee S.M., Ware C.F., Jenkins N.A., Gilbert D.J., Yagita H., Copeland N.G., Okumura K.Genomics 42:26-32(1997) The TNF-receptor-associated factor family scaffold molecules for cytokine receptors, kinases and their regulators.Wajant H., Henkler F., Scheurich P.Cell. Signal. 13:389-400(2001) Tumor necrosis factor receptor-associated factors (TRAFs) .Bradley J.R., Pober J.S.Oncogene 20:6482-6491(2001) Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1.Marsters S.A., Ayres T.M., Skubatch M., Gray C.L., Rothe M., Ashkenazi A.J. Biol. Chem. 272:14029-14032(1997) ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5.Hsu H., Solovyev I., Colombero A., Elliott R., Kelley M., Boyle W.J.J. Biol. Chem. 272:13471-13474(1997) Tumor necrosis factor (TNF) -mediated kinase cascades bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2.Song H.Y., Regnier C.H., Kirschning C.J., Goeddel D.V., Rothe M.Proc. Natl. Acad. Sci. U.S.A. 94:9792-9796(1997) Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NFkappaB activation.Aizawa S., Nakano H., Ishida T., Horie R., Nagai M., Ito K., Yagita H., Okumura K., Inoue J., Watanabe T.J. Biol. Chem. 272:2042-2045(1997) ASK1 is essential for JNK/SAPK activation by TRAF2.Nishitoh H., Saitoh M., Mochida Y., Takeda K., Nakano H., Rothe M., Miyazono K., Ichijo H.Mol. Cell 2:389-395(1998) CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization.Pullen S.S., Miller H.G., Everdeen D.S., Dang T.T., Crute J.J., Kehry M.R.Biochemistry 37:11836-11845(1998) Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5-mediated NF-kappaB activation.Kawamata S., Hori T., Imura A., Takaori-Kondo A., Uchiyama T.J. Biol. Chem. 273:5808-5814(1998) RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase.McCarthy J.V., Ni J., Dixit V.M.J. Biol. Chem. 273:16968-16975(1998) TAJ, a novel member of the tumor necrosis factor receptor family, activates the c-Jun N-terminal kinase pathway and mediates caspase-independent cell death.Eby M.T., Jasmin A., Kumar A., Sharma K., Chaudhary P.M.J. Biol. Chem. 275:15336-15342(2000) The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor.Wong B.R., Josien R., Lee S.Y., Vologodskaia M., Steinman R.M., Choi Y.J. Biol. Chem. 273:28355-28359(1998) TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs) , and that inhibits nuclear factor-kappa B activation.Pype S., Declercq W., Ibrahimi A., Michiels C., Van Rietschoten J.G.I., Dewulf N., de Boer M., Vandenabeele P., Huylebroeck D., Remacle J.E.J. Biol. Chem. 275:18586-18593(2000) TACI is a TRAF-interacting receptor for TALL-1, a tumor necrosis factor family member involved in B cell regulation.Xia X.-Z., Treanor J., Senaldi G., Khare S.D., Boone T., Kelley M., Theill L.E., Colombero A., Solovyev I., Lee F., McCabe S., Elliott R., Miner K., Hawkins N., Guo J., Stolina M., Yu G., Wang J., Delaney J., Meng S.-Y., Boyle W.J., Hsu H.J. Exp. Med. 192:137-143(2000) B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1.Shu H.-B., Johnson H.Proc. Natl. Acad. Sci. U.S.A. 97:9156-9161(2000) TRAF family proteins link PKR with NF-kappa B activation.Gil J., Garcia M.A., Gomez-Puertas P., Guerra S., Rullas J., Nakano H., Alcami J., Esteban M.Mol. Cell. Biol. 24:4502-4512(2004) Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.Sci. Signal. 2:RA46-RA46(2009)

Small volumes of TRAF5 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS1014127 is a recombinant protein targeting TRAF5. Also known as Recombinant Human TNF receptor-associated factor 5 (TRAF5). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.