Serotype 2 Fimbrial Subunit (fim2) Bordetella Pertussis Recombinant Protein

Bordetella pertussis is the causative agent of whooping cough. An essential step in the disease process is the attachment of the bacteria to the ciliated epithelium of the respiratory tract, enabling the organism to resist normal host-clearance mechanisms. It is unclear which bacterial cell surface component are responsible for adherence but the fimbriae of B. pertussis are prime candidates for being involved in this process.

Cloning and nucleotide sequence analysis of the serotype 2 fimbrial subunit gene of Bordetella pertussis.Livey I., Duggleby C.J., Robinson A.Mol. Microbiol. 1:203-209(1987) Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica.Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S., Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J.Nat. Genet. 35:32-40(2003)

Small volumes of fim2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Bordetella pertussis infection (Whooping cough) is making a serious comeback globally due to insufficient and lapsing immunizations. Therefore, a resurgence in research into Bordetella pertussis and serotype 2 fimbrial subunit specifically is warranted. To assist our research community, MyBioSource has a highly purified recombinant protein ready for your use. You can chose among most common expression systems from Escherichia coli to mammalian cells with C or N-terminal tag regions. Like cholera toxin gene product, recombinant Bordetella pertussis serotype 2 FIM is genome sequence blast search validated and can be custom ordered through our technical service resources. Uses for fimbria 2 protein include ELISA kits development, both as an antigen control and for antibodies generation, cell biology inhibition experiments and comparative studies to immunization recombinant cholera toxin CTB in mice - see cited PMC free article for details. Find all our recombinant protein in an alphabetical list on MyBioSource.com.