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Sphingolipid Delta (4)-Desaturase DES1 (DEGS1) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1016321

MBS1016321 is a recombinant protein targeting Degs1. Also known as Recombinant Mouse Sphingolipid delta (4)-desaturase DES1 (Degs1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Sphingolipid delta (4)-desaturase DES1 (Degs1), Recombinant Protein
Full Product Name
Recombinant Mouse Sphingolipid delta (4)-desaturase DES1 (Degs1)
Product Gene Name
Degs1 recombinant protein
Product Synonym Gene Name
Degs1; Degs, Des1, Mdes
Product Synonym Names
Recombinant Sphingolipid delta (4)-desaturase DES1 (Degs1); Sphingolipid delta(4)-desaturase DES1 EC= 1.14.-.-; Degenerative spermatocyte homolog 1
Sequence
GSRVSREEFE WVYTDQPHAA RRKEILAKYP EIKSLMKPDH NLIWIVAMML LVQLASFYLV KDLDWKWVIF WSYVFGSCLN HSMTLAIHEI SHNFPFGHHK ALWNRWFGMF ANLSLGVPYS ISFKRYHMDH HRYLGADKID VDIPTDFEGW FFCTTFRKFV WVILQPLFYA FRPLFINPKP ITYLEIINTV IQITFDIIIY YVFGVKSLVY MLAATLLGLG LHPISGHFIA EHYMFLKGHE TYSYYGPLNL LTFNVGYHNE HHDFPNVPGK NLPMVRKIAS EYYDDLPHYN SWIKVLYDFV TDDTISPYSR MKRPPKGNEI LE
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
Molecular Weight
38,241 Da
Sequence Positions
2-323
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Chromosome Location
Chromosome: 1; NC_000067.6 (182275770..182282759, complement). Location: 1; 1 H5
3D Structure
ModBase 3D Structure for O09005
Species
Mus musculus (Mouse)
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Degs1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Degs1. It may not necessarily be applicable to this product.

NCBI GI #
6681175
NCBI GeneID
13244
NCBI Accession #
NP_031879.1
UniProt Primary Accession #
O09005
UniProt Secondary Accession #
Q8R4H3
UniProt Related Accession #
O09005
GenBank Nucleotide #
NM_007853.4
NCBI Official Full Name
sphingolipid delta(4)-desaturase DES1
NCBI Official Synonym Full Names
degenerative spermatocyte homolog 1 (Drosophila)
NCBI Official Symbol
Degs1
NCBI Official Synonym Symbols
Degs; Des1; Mdes; AA536663
UniProt Protein Name
Sphingolipid delta(4)-desaturase DES1
UniProt Synonym Protein Names
Degenerative spermatocyte homolog 1
UniProt Gene Name
Degs1
UniProt Synonym Gene Names
Degs; Des1; Mdes
UniProt Entry Name
DEGS1_MOUSE
NCBI Protein Information
sphingolipid delta(4)-desaturase DES1; sphingolipid delta(4)-desaturase DES1; dihydroceramide desaturase

UniProt Comments for Degs1

DEGS1: Has sphingolipid-delta-4-desaturase activity. Converts D-erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine). Belongs to the fatty acid desaturase family. DEGS subfamily.

Protein type: Membrane protein, integral; EC 1.14.-.-; Oxidoreductase; Membrane protein, multi-pass; Lipid Metabolism - sphingolipid

Cellular Component: mitochondrion; membrane; endoplasmic reticulum; integral to membrane

Molecular Function: tert-butyl alcohol 2-monooxygenase activity; methylsilanetriol hydroxylase activity; alpha-pinene dehydrogenase activity; hydroxymethylsilanetriol oxidase activity; oxidoreductase activity; fluorene oxygenase activity; tri-n-butyltin dioxygenase activity; 2-hydroxyisobutyrate 3-monooxygenase activity; 4-nitrocatechol 4-monooxygenase activity; alpha-pinene monooxygenase activity; spheroidene monooxygenase activity; dimethylsilanediol hydroxylase activity; ammonia monooxygenase activity; mono-butyltin dioxygenase activity; 4-chlorophenoxyacetate monooxygenase activity; methyl tertiary butyl ether 3-monooxygenase activity; sphingolipid delta-4 desaturase activity; di-n-butyltin dioxygenase activity

Biological Process: sphingolipid biosynthetic process; positive regulation of apoptosis; ceramide biosynthetic process; lipid metabolic process; fatty acid metabolic process; fatty acid biosynthetic process
Show more

Research Articles on Degs1

1. overexpression of DEGS1 or DEGS2 attenuates the DHC accumulation and increased cell proliferation during hypoxia

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Degs1 recombinant protein

 Products by Pathway  Pathway Diagram
 Ceramide Biosynthesis Pathway antibodies  Ceramide Biosynthesis Pathway Diagram
 Ceramide Biosynthesis Pathway antibodies  Ceramide Biosynthesis Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Sphingolipid De Novo Biosynthesis Pathway antibodies  Sphingolipid De Novo Biosynthesis Pathway Diagram
 Sphingolipid Metabolism Pathway antibodies  Sphingolipid Metabolism Pathway Diagram
 Sphingolipid Metabolism Pathway antibodies  Sphingolipid Metabolism Pathway Diagram
 Sphingolipid Metabolism Pathway antibodies  Sphingolipid Metabolism Pathway Diagram
 Sphingolipids Metabolism Pathway antibodies  Sphingolipids Metabolism Pathway Diagram
 Sphingosine Biosynthesis Pathway antibodies  Sphingosine Biosynthesis Pathway Diagram

Diseases associated with Degs1 recombinant protein

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >2 publications with Degs1 and Neoplasms
 Skin Diseases Antibodies  >1 publications with Degs1 and Skin Diseases
 Breast Neoplasms Antibodies  >1 publications with Degs1 and Breast Neoplasms
 Neoplasm Metastasis Antibodies  >1 publications with Degs1 and Neoplasm Metastasis

Organs/Tissues associated with Degs1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2 publications with Degs1 and Blood
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