Human ICOSLG Recombinant Protein – Cat# MBS1017464

ICOS Ligand (ICOSLG) Human Recombinant Protein

Name: ICOSLG Recombinant Protein; ICOS Ligand; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1017464
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1017464

MBS1017464 is a recombinant protein targeting ICOSLG. Also known as Recombinant Human ICOS ligand (ICOSLG). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ICOS ligand (ICOSLG), Recombinant Protein

Full Product Name

Recombinant Human ICOS ligand (ICOSLG)

Product Gene Name

ICOSLG recombinant protein

Product Synonym Gene Name

ICOSLG; B7H2; B7RP1; ICOSL; KIAA0653

Product Synonym Names

ICOS ligand; B7 homolog 2; B7-H2; B7-like protein Gl50; B7-related protein 1; B7RP-1; CD_antigen=; CD275

Sequence

DT QEKEVRAMVG SDVELSCACP EGSRFDLNDV YVYWQTSESK TVVTYHIPQN SSLENVDSRY RNRALMSPAG MLRGDFSLRL FNVTPQDEQK FHCLVLSQSL GFQEVLSVEV TLHVAANFSV PVVSAPHSPS QDELTFTCTS INGYPRPNVY WINKTDNSLL DQALQNDTVF LNMRGLYDVV SVLRIARTPS VNIGCCIENV LLQQNLTVGS QTGNDIGERD KITENPVSTG EKNAAT

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

20,120 Da

Sequence Positions

19-256

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

605717

3D Structure

ModBase 3D Structure for O75144

Species

Homo sapiens (Human)

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of ICOSLG recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ICOSLG. It may not necessarily be applicable to this product.

NCBI GI #

545688560

NCBI GeneID

23308

NCBI Accession #

NP_001269979.1

UniProt Primary Accession #

O75144

UniProt Secondary Accession #

Q9HD18; Q9NRQ1; A8MUZ1

UniProt Related Accession #

O75144

GenBank Nucleotide #

NM_001283050.1

NCBI Official Full Name

ICOS ligand isoform b

NCBI Official Synonym Full Names

inducible T-cell co-stimulator ligand

NCBI Official Symbol

ICOSLG

NCBI Official Synonym Symbols

B7H2; GL50; B7-H2; B7RP1; CD275; ICOSL; LICOS; B7RP-1; ICOS-L

UniProt Protein Name

ICOS ligand

UniProt Synonym Protein Names

B7 homolog 2; B7-H2; B7-like protein Gl50; B7-related protein 1; B7RP-1; CD_antigen: CD275

Protein Family

ICOS ligand

UniProt Gene Name

ICOSLG

UniProt Synonym Gene Names

B7H2; B7RP1; ICOSL; KIAA0653; B7-H2; B7RP-1

UniProt Entry Name

ICOSL_HUMAN

NCBI Protein Information

ICOS ligand; B7 homolog 2; B7 homologue 2; B7-like protein Gl50; B7-related protein 1; transmembrane protein B7-H2 ICOS ligand

UniProt Comments for ICOSLG

ICOSLG: Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co- stimulating memory T-cell function. Belongs to the immunoglobulin superfamily. BTN/MOG family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: plasma membrane; integral to membrane

Molecular Function: receptor binding

Biological Process: hyperosmotic response; T cell activation; B cell activation; T cell costimulation; defense response; positive regulation of activated T cell proliferation; signal transduction

Research Articles on ICOSLG

1. a critical role is described for the rs7282490 ICOSLG region polymorphism associated with immune-mediated diseases in amplifying pattern-recognition receptor initiated inflammatory signaling and cytokine secretion

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with ICOSLG recombinant protein

Reference Product	PubMed Publications
ICOS recombinant protein	>56 publications with ICOSLG and ICOS
TNFSF18 recombinant protein	>3 publications with ICOSLG and TNFSF18
PTPRC recombinant protein	>1 publications with ICOSLG and PTPRC

Pathways associated with ICOSLG recombinant protein

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram
Costimulation By The CD28 Family Pathway antibodies	Costimulation By The CD28 Family Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Intestinal Immune Network For IgA Production Pathway antibodies	Intestinal Immune Network For IgA Production Pathway Diagram
Intestinal Immune Network For IgA Production Pathway antibodies	Intestinal Immune Network For IgA Production Pathway Diagram

Diseases associated with ICOSLG recombinant protein

Disease Name	Pubmed Publications
Immune System Diseases Antibodies	>25 publications with ICOSLG and Immune System Diseases
Necrosis Antibodies	>21 publications with ICOSLG and Necrosis
Autoimmune Diseases Antibodies	>15 publications with ICOSLG and Autoimmune Diseases
Inflammation Antibodies	>13 publications with ICOSLG and Inflammation
Nervous System Diseases Antibodies	>6 publications with ICOSLG and Nervous System Diseases
Carcinoma Antibodies	>6 publications with ICOSLG and Carcinoma
Arthritis, Rheumatoid Antibodies	>4 publications with ICOSLG and Arthritis, Rheumatoid
Colitis Antibodies	>4 publications with ICOSLG and Colitis
Colitis, Ulcerative Antibodies	>3 publications with ICOSLG and Colitis, Ulcerative
Carcinoma, Squamous Cell Antibodies	>2 publications with ICOSLG and Carcinoma, Squamous Cell

Organs/Tissues associated with ICOSLG recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>71 publications with ICOSLG and Blood
Brain Antibodies	>5 publications with ICOSLG and Brain
Kidney Antibodies	>4 publications with ICOSLG and Kidney
Liver Antibodies	>4 publications with ICOSLG and Liver
Skin Antibodies	>4 publications with ICOSLG and Skin
Heart Antibodies	>4 publications with ICOSLG and Heart
Lung Antibodies	>4 publications with ICOSLG and Lung
Lymph Node Antibodies	>4 publications with ICOSLG and Lymph Node
Stomach Antibodies	>2 publications with ICOSLG and Stomach
Connective Tissue Antibodies	>2 publications with ICOSLG and Connective Tissue