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Potassium Voltage-Gated Channel Subfamily S Member 3 (KCNS3) Rat Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1018486

MBS1018486 is a recombinant protein targeting Kcns3. Also known as Recombinant Rat Potassium voltage-gated channel subfamily S member 3 (Kcns3). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Potassium voltage-gated channel subfamily S member 3 (Kcns3), Recombinant Protein
Full Product Name
Recombinant Rat Potassium voltage-gated channel subfamily S member 3 (Kcns3)
Product Gene Name
Kcns3 recombinant protein
Product Synonym Gene Name
Kcns3
Product Synonym Names
Recombinant Potassium voltage-gated channel subfamily S member 3 (Kcns3); Potassium voltage-gated channel subfamily S member 3; Delayed-rectifier K(+) channel alpha subunit 3 Voltage-gated potassium channel subunit Kv9.3
Sequence
MVFGEFFHRP GQDEELVNLN VGGFKQSVDQ STLLRFPHTR LGKLLTCHSE EAILELCDDY SVADKEYYFD RNPSLFRYVL NFYYTGKLHV MEELCVFSFC QEIEYWGINE LFIDSCCSSR YQERKEESHE KDWDQKSNDV STDSSFEESS LFEKELEKFD ELRFGQLRKK IWIRMENPAY CLSAKLIAIS SLSVVLASIV AMCVHSMSEF QNEDGEVDDP VLEGVEIACI AWFTGELAIR LVAAPSQKKF WKNPLNIIDF VSIIPFYATL AVDTKEEESE DIENMGKVVQ ILRLMRIFRI LKLARHSVGL RSLGATLRHS YHEVGLLLLF LSVGISIFSV LIYSVEKDEL ASSLTSIPIC WWWATISMTT VGYGDTHPVT LAGKIIASTC IICGILVVAL PITIIFNKFS KYYQKQKDMD VDQCSEDPPE KCHELPYFNI RDVYAQQVHA FITSLSSIGI VVSDPDSTDA SSVEDNEDAY NTASLENCTA K
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
Molecular Weight
55,866 Da
Sequence Positions
1-491
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Chromosome Location
Chromosome: 6; NC_005105.3 (46515725..46571008, complement). Location: 6q14
3D Structure
ModBase 3D Structure for O88759
Species
Rattus norvegicus (Rat)
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Kcns3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Kcns3. It may not necessarily be applicable to this product.

NCBI GI #
31543041
NCBI GeneID
83588
NCBI Accession #
NP_113966.2
UniProt Primary Accession #
O88759
UniProt Secondary Accession #
O54900
UniProt Related Accession #
O88759
GenBank Nucleotide #
NM_031778.2
NCBI Official Full Name
potassium voltage-gated channel subfamily S member 3
NCBI Official Synonym Full Names
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3
NCBI Official Symbol
Kcns3
UniProt Protein Name
Potassium voltage-gated channel subfamily S member 3
UniProt Synonym Protein Names
Delayed-rectifier K(+) channel alpha subunit 3; Voltage-gated potassium channel subunit Kv9.3
Protein Family
Potassium voltage-gated channel subfamily
UniProt Gene Name
Kcns3
UniProt Entry Name
KCNS3_RAT
NCBI Protein Information
potassium voltage-gated channel subfamily S member 3; voltage-gated potassium channel subunit Kv9.3; delayed-rectifier K(+) channel alpha subunit 3; Shab-related delayed-rectifier K+ channel (Kv9.3)

NCBI Summary for Kcns3

delayed-rectifier potassium channel alpha subunit [RGD, Feb 2006]

UniProt Comments for Kcns3

Function: Potassium channel subunit. Modulates channel activity and shifts the activation threshold of KCNB1 to more negative values.

Subunit structure: Heteromultimer with KCNB1 and with KCNB2. Does not form homomultimers. Might also bind to other channel proteins

By similarity.

Subcellular location: Cell membrane; Multi-pass membrane protein

By similarity. Note: May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1

By similarity.

Tissue specificity: Detected in lung, spleen, brain and heart.

Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Miscellaneous: Inhibited by 4-aminopyridine (4-AP). Channel activity is reversibly inhibited by hypoxia and down-regulated in the absence of intracellular ATP.

Sequence similarities: Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.3/KCNS3 sub-subfamily. [View classification]
Show more

Research Articles on Kcns3

1. different Kv9.3/Kv2.1 ratios could have physiological implications in lung and brain during post-natal development, and that diet composition and selective tissue-specific insulin regulation modulate the expression of Kv2.1 and Kv9.3.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Kcns3 recombinant protein

 Products by Pathway  Pathway Diagram
 Integration Of Energy Metabolism Pathway antibodies  Integration Of Energy Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Potassium Channels Pathway antibodies  Potassium Channels Pathway Diagram
 Regulation Of Insulin Secretion Pathway antibodies  Regulation Of Insulin Secretion Pathway Diagram
 Regulation Of Insulin Secretion By Glucagon-like Peptide-1 Pathway antibodies  Regulation Of Insulin Secretion By Glucagon-like Peptide-1 Pathway Diagram
 Voltage Gated Potassium Channels Pathway antibodies  Voltage Gated Potassium Channels Pathway Diagram

Diseases associated with Kcns3 recombinant protein

 Disease Name  Pubmed Publications
 Respiratory Tract Diseases Antibodies  >2 publications with Kcns3 and Respiratory Tract Diseases
 Brain Diseases Antibodies  >1 publications with Kcns3 and Brain Diseases
 Nervous System Diseases Antibodies  >1 publications with Kcns3 and Nervous System Diseases

Organs/Tissues associated with Kcns3 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >1 publications with Kcns3 and Lung
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