Rat GGCX Recombinant Protein – Cat# MBS1021877

Vitamin K-Dependent Gamma-Carboxylase (GGCX) Rat Recombinant Protein

Name: GGCX Recombinant Protein; Rat; MyBioSource
Brand: MyBioSource
SKU: MBS1021877
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1021877

MBS1021877 is a recombinant protein targeting Ggcx. Also known as Recombinant Rat Vitamin K-dependent gamma-carboxylase (Ggcx). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. Ggcx More details

Please Inquire

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Vitamin K-dependent gamma-carboxylase (Ggcx), Recombinant Protein

Full Product Name

Recombinant Rat Vitamin K-dependent gamma-carboxylase (Ggcx)

Product Gene Name

Ggcx recombinant protein

Product Synonym Gene Name

Recombinant Vitamin K-dependent gamma-carboxylase (Ggcx); Vitamin K-dependent gamma-carboxylase EC= 4.1.1.90; Gamma-glutamyl carboxylase Peptidyl-glutamate 4-carboxylase Vitamin K gamma glutamyl carboxylase

Sequence

AVHRGSARAA PASDKVQKNK PAQTSGLEQG SRMARIFGFE WADLSSWQSV VTLLNRPTDP ANLAVFRFLF AFLMLLDIPQ ERGLSSLDRK YLDGLDVCRF PLLDALRPLP LDWMYLVYTI MFLGALGMML GLWYRLSCML FLLPYWYVFL LDKTSWNNHS YLYGLLAFQL TFMDANHYWS VDGLLSAQKK NAHVPLWNYT VLRGQIFIVY FIAGVKKLDA DWVEGYSMEH LSRHWLFSPF KLVLSEELTS LLVVHWCGLL LDLSAGFLLF FDASRPIGLV FVSYFHCMNS QLFSIGMFPY VMLASSPLFC SAEWPRKLVA RCPKRLQELL PAKAAPRPSA SCVYKRARAK AGQKPGLRHH LGTVFTLLYL LEQLFLPYSH FLTQGYNNWT NGLYGYSWDM MVHSRSHQHV KITYRDGLTG ELGYLNPGVF TQSRRWKDHA DMLKQYATCL SLLLPKYNVT EPQIYFDIWV SINDRFQQRL FDPRVDIVQA VWSPFRRTPW VQPLLMDLSP WRTKLQDIKS SLDNHTEVVF IADFPGLHLE NFVSEDLGNT SIQLLQGEVT VELVAEQKNQ TLREGEKMQL PAGEYHKVYT VSSSPSCYMY IYVNTTEVAL EQDLAYLQEL KEKVENGSET GPLPPELQPL LEGEVKGGPE PTPLVQTFLR RQRKLQEIER RRNSPLHERF LRFVLRKLYV FRRSFLMTRI SLRNLLFGRP SLEQLAQEVT YANLRPFEPV DESSASNTDS SDPHPSEPDS EHVHSEL

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

Molecular Weight

87,479 Da

Sequence Positions

2-758

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

Chromosome Location

Chromosome: 4; NC_005103.3 (165047672..165063604). Location: 4q33

3D Structure

ModBase 3D Structure for O88496

Species

Rattus norvegicus (Rat)

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Ggcx recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Ggcx. It may not necessarily be applicable to this product.

NCBI GI #

13929062

NCBI GeneID

81716

NCBI Accession #

NP_113944.1

UniProt Primary Accession #

O88496

UniProt Related Accession #

O88496

GenBank Nucleotide #

NM_031756.1

NCBI Official Full Name

vitamin K-dependent gamma-carboxylase

NCBI Official Synonym Full Names

gamma-glutamyl carboxylase

NCBI Official Symbol

Ggcx

UniProt Protein Name

Vitamin K-dependent gamma-carboxylase

UniProt Synonym Protein Names

Gamma-glutamyl carboxylase; Peptidyl-glutamate 4-carboxylase; Vitamin K gamma glutamyl carboxylase

Protein Family

Vitamin K-dependent gamma-carboxylase

UniProt Gene Name

Ggcx

UniProt Entry Name

VKGC_RAT

NCBI Protein Information

vitamin K-dependent gamma-carboxylase; peptidyl-glutamate 4-carboxylase; vitamin K gamma glutamyl carboxylase

NCBI Summary for Ggcx

catalyzes the posttranslational modification of glutamate to gamma-carboxyglutamate (Gla); may mediate functions of vitamin K-dependent proteins (VKDPs) [RGD, Feb 2006]

UniProt Comments for Ggcx

Function: Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide.

Catalytic activity: [Peptidyl]-4-carboxyglutamate + 2,3-epoxyphylloquinone + H2O = [peptidyl]-glutamate + CO2 + O2 + phylloquinone.

Subunit structure: Monomer

By similarity. Interacts with CALU. Ref.3

Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein

By similarity.

Miscellaneous: The vitamin K-dependent protein substrates of carboxylase have usually a propeptide that binds to a high-affinity site on the carboxylase. CO2, O2 and reduced vitamin K are cosubstrates.

Sequence similarities: Belongs to the vitamin K-dependent gamma-carboxylase family.

Research Articles on Ggcx

1. Both carboxylase activity and formation of gamma-carboxyglutamate (Gla)-containing proteins were stimulated by dexamethasone (Dex) in fetal type II lung cells

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Ggcx recombinant protein

Products by Pathway	Pathway Diagram
Gamma-carboxylation Of Protein Precursors Pathway antibodies	Gamma-carboxylation Of Protein Precursors Pathway Diagram
Gamma-carboxylation, Transport, And Amino-terminal Cleavage Of Proteins Pathway antibodies	Gamma-carboxylation, Transport, And Amino-terminal Cleavage Of Proteins Pathway Diagram
Metabolism Of Proteins Pathway antibodies	Metabolism Of Proteins Pathway Diagram
PTM: Gamma Carboxylation, Hypusine Formation And Arylsulfatase Activation Pathway antibodies	PTM: Gamma Carboxylation, Hypusine Formation And Arylsulfatase Activation Pathway Diagram
Post-translational Protein Modification Pathway antibodies	Post-translational Protein Modification Pathway Diagram

Diseases associated with Ggcx recombinant protein

Disease Name	Pubmed Publications
Vascular Diseases Antibodies	>20 publications with Ggcx and Vascular Diseases
Hemostatic Disorders Antibodies	>10 publications with Ggcx and Hemostatic Disorders
Thrombosis Antibodies	>8 publications with Ggcx and Thrombosis
Blood Coagulation Disorders Antibodies	>6 publications with Ggcx and Blood Coagulation Disorders
Thromboembolism Antibodies	>5 publications with Ggcx and Thromboembolism
Hemorrhage Antibodies	>4 publications with Ggcx and Hemorrhage
Nervous System Diseases Antibodies	>3 publications with Ggcx and Nervous System Diseases
Brain Diseases Antibodies	>3 publications with Ggcx and Brain Diseases
Disease Models, Animal Antibodies	>2 publications with Ggcx and Disease Models, Animal
Hydronephrosis Antibodies	>2 publications with Ggcx and Hydronephrosis

Organs/Tissues associated with Ggcx recombinant protein

Organ/Tissue Name	Pubmed Publications
Connective Tissue Antibodies	>5 publications with Ggcx and Connective Tissue
Liver Antibodies	>4 publications with Ggcx and Liver
Heart Antibodies	>4 publications with Ggcx and Heart
Kidney Antibodies	>2 publications with Ggcx and Kidney
Artery Antibodies	>1 publications with Ggcx and Artery