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C-X-C Chemokine Receptor Type 4 (CXCR4) Rat Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1023582

MBS1023582 is a recombinant protein targeting Cxcr4. Also known as Recombinant Rat C-X-C chemokine receptor type 4 (Cxcr4), partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$880 / 0.05 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
C-X-C chemokine receptor type 4 (Cxcr4), Recombinant Protein
Full Product Name
Recombinant Rat C-X-C chemokine receptor type 4 (Cxcr4), partial
Product Gene Name
Cxcr4 recombinant protein
Sequence
AFLGAKFKSS AQHALNSMSR GSSLKILSKG KRGGHSSVST ESESSSFHSS
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
39,334 Da
Sequence Positions
300-349. Fragment at the C-terminal, provide the last complete cytoplasmic domain.
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for O08565
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Cxcr4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Cxcr4. It may not necessarily be applicable to this product.

NCBI GI #
2494971
NCBI GeneID
60628
NCBI Accession #
O08565.1
UniProt Primary Accession #
O08565
UniProt Related Accession #
O08565
NCBI Official Full Name
C-X-C chemokine receptor type 4
NCBI Official Synonym Full Names
C-X-C motif chemokine receptor 4
NCBI Official Symbol
Cxcr4
UniProt Protein Name
C-X-C chemokine receptor type 4
UniProt Synonym Protein Names
Fusin; Leukocyte-derived seven transmembrane domain receptor; LESTR; Stromal cell-derived factor 1 receptor; SDF-1 receptor; CD_antigen: CD184
Protein Family
C-X-C chemokine receptor
UniProt Gene Name
Cxcr4
UniProt Synonym Gene Names
Cmkar4; CXC-R4; CXCR-4; LESTR; SDF-1 receptor
NCBI Protein Information
C-X-C chemokine receptor type 4

NCBI Summary for Cxcr4

G protein-coupled receptor for the chemokine stromal cell-derived factor-1; may have a role in brain development [RGD, Feb 2006]

UniProt Comments for Cxcr4

Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival (). Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes ().
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Research Articles on Cxcr4

1. Gene expression and localization of SDF-1 and CXCR4 was altered during fracture healing, which may contribute to the impaired fracture healing in DM.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Cxcr4 recombinant protein

 Reference Product  PubMed Publications
 CXCL12 recombinant protein  >2499 publications with Cxcr4 and CXCL12
 CCR5 recombinant protein  >2228 publications with Cxcr4 and CCR5
 CD4 recombinant protein  >1872 publications with Cxcr4 and CD4
 PTPRC recombinant protein  >109 publications with Cxcr4 and PTPRC
 STAT3 recombinant protein  >32 publications with Cxcr4 and STAT3
 JAK2 recombinant protein  >17 publications with Cxcr4 and JAK2
 STAT1 recombinant protein  >11 publications with Cxcr4 and STAT1
 PTK2 recombinant protein  >11 publications with Cxcr4 and PTK2
 SOCS3 recombinant protein  >8 publications with Cxcr4 and SOCS3
 JAK3 recombinant protein  >7 publications with Cxcr4 and JAK3

Pathways associated with Cxcr4 recombinant protein

 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 IL-4 Signaling Pathway antibodies  IL-4 Signaling Pathway Diagram

Diseases associated with Cxcr4 recombinant protein

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1526 publications with Cxcr4 and Neoplasms
 Inflammation Antibodies  >461 publications with Cxcr4 and Inflammation
 Neoplasm Metastasis Antibodies  >438 publications with Cxcr4 and Neoplasm Metastasis
 Carcinoma Antibodies  >418 publications with Cxcr4 and Carcinoma
 Cardiovascular Diseases Antibodies  >347 publications with Cxcr4 and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >327 publications with Cxcr4 and Nervous System Diseases
 Disease Models, Animal Antibodies  >309 publications with Cxcr4 and Disease Models, Animal
 Breast Neoplasms Antibodies  >302 publications with Cxcr4 and Breast Neoplasms
 Necrosis Antibodies  >225 publications with Cxcr4 and Necrosis
 Lung Diseases Antibodies  >214 publications with Cxcr4 and Lung Diseases

Organs/Tissues associated with Cxcr4 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3044 publications with Cxcr4 and Blood
 Bone Antibodies  >1153 publications with Cxcr4 and Bone
 Bone Marrow Antibodies  >1029 publications with Cxcr4 and Bone Marrow
 Vascular Antibodies  >738 publications with Cxcr4 and Vascular
 Brain Antibodies  >512 publications with Cxcr4 and Brain
 Lung Antibodies  >329 publications with Cxcr4 and Lung
 Lymph Node Antibodies  >323 publications with Cxcr4 and Lymph Node
 Lymph Antibodies  >314 publications with Cxcr4 and Lymph
 Liver Antibodies  >290 publications with Cxcr4 and Liver
 Muscle Antibodies  >232 publications with Cxcr4 and Muscle
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