Human BIN1 Recombinant Protein – Cat# MBS1026776

Myc Box-Dependent-Interacting Protein 1 (BIN1) Human Recombinant Protein

Name: BIN1 Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1026776
Price: 1385 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1026776

$1385 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Myc box-dependent-interacting protein 1 (BIN1), Recombinant Protein

Full Product Name

Recombinant Human Myc box-dependent-interacting protein 1 (BIN1)

Product Gene Name

BIN1 recombinant protein

Sequence

AEMGSKGVTA GKIASNVQKK LTRAQEKVLQ KLGKADETKD EQFEQCVQNF NKQLTEGTRL QKDLRTYLAS VKAMHEASKK LNECLQEVYE PDWPGRDEAN KIAENNDLLW MDYHQKLVDQ ALLTMDTYLG QFPDIKSRIA KRGRKLVDYD SARHHYESLQ TAKKKDEAKI AKPVSLLEKA APQWCQGKLQ AHLVAQTNLL RNQAEEELIK AQKVFEEMNV DLQEELPSLW NSRVGFYVNT FQSIAGLEEN FHKEMSKLNQ NLNDVLVGLE KQHGSNTFTV KAQPSDNAPA KGNKSPSPPD GSPAATPEIR VNHEPEPAGG ATPGATLPKS PSQLRKGPPV PPPPKHTPSK EVKQEQILSL FEDTFVPEIS VTTPSQFEAP GPFSEQASLL DLDFDPLPPV TSPVKAPTPS GQSIPWDLWE PTESPAGSLP SGEPSAAEGT FAVSWPSQTA EPGPAQPAEA SEVAGGTQPA AGAQEPGETA ASEAASSSLP AVVVETFPAT VNGTVEGGSG AGRLDLPPGF MFKVQAQHDY TATDTDELQL KAGDVVLVIP FQNPEEQDEG WLMGVKESDW NQHKELEKCR GVFPENFTER VP

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

54,948 Da

Sequence Positions

2-593, Full length protein

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

255200

3D Structure

ModBase 3D Structure for O00499

Species

Human

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of BIN1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BIN1 purchase

MBS1026776 is a recombinant protein targeting BIN1. Also known as Recombinant Human Myc box-dependent-interacting protein 1 (BIN1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for BIN1. It may not necessarily be applicable to this product.

NCBI GI #

1002341801

NCBI GeneID

274

NCBI Accession #

NP_001307561.1

UniProt Primary Accession #

O00499

UniProt Secondary Accession #

O00297; O00545; O43867; O60552; O60553; O60554; O60555; O75514; O75515; O75516; O75517

UniProt Related Accession #

O00499

GenBank Nucleotide #

NM_001320632.1

NCBI Official Full Name

myc box-dependent-interacting protein 1 isoform 13

NCBI Official Synonym Full Names

bridging integrator 1

NCBI Official Symbol

BIN1

NCBI Official Synonym Symbols

CNM2; AMPH2; AMPHL; SH3P9

UniProt Protein Name

Myc box-dependent-interacting protein 1

UniProt Synonym Protein Names

Amphiphysin II; Amphiphysin-like protein; Box-dependent myc-interacting protein 1; Bridging integrator 1

Protein Family

Myc box-dependent-interacting protein

UniProt Gene Name

BIN1

UniProt Synonym Gene Names

AMPHL

NCBI Protein Information

myc box-dependent-interacting protein 1

NCBI Summary for BIN1

This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in several transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described. [provided by RefSeq, Mar 2016]

UniProt Comments for BIN1

May be involved in regulation of synaptic vesicle endocytosis. May act as a tumor suppressor and inhibits malignant cell transformation.

Research Articles on BIN1

1. bridging integrator 1 Gene rs7561528 polymorphism contributes to Alzheimer's disease susceptibility in East Asian and Caucasian populations

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with BIN1 recombinant protein

Reference Product	PubMed Publications
PICALM recombinant protein	>71 publications with BIN1 and PICALM
MYC recombinant protein	>44 publications with BIN1 and MYC
EPS15 recombinant protein	>4 publications with BIN1 and EPS15
MAPT recombinant protein	>3 publications with BIN1 and MAPT
BIN2 recombinant protein	>3 publications with BIN1 and BIN2
RIN3 recombinant protein	>3 publications with BIN1 and RIN3
SYNJ1 recombinant protein	>1 publications with BIN1 and SYNJ1
DNM1 recombinant protein	>1 publications with BIN1 and DNM1

Pathways associated with BIN1 recombinant protein

Products by Pathway	Pathway Diagram
Arf6 Trafficking Events Pathway antibodies	Arf6 Trafficking Events Pathway Diagram
Clathrin-mediated Endocytosis Pathway antibodies	Clathrin-mediated Endocytosis Pathway Diagram
Endocytosis Pathway antibodies	Endocytosis Pathway Diagram
Endocytosis Pathway antibodies	Endocytosis Pathway Diagram
Fc Gamma R-mediated Phagocytosis Pathway antibodies	Fc Gamma R-mediated Phagocytosis Pathway Diagram
Fc Gamma R-mediated Phagocytosis Pathway antibodies	Fc Gamma R-mediated Phagocytosis Pathway Diagram
Membrane Trafficking Pathway antibodies	Membrane Trafficking Pathway Diagram
Vesicle-mediated Transport Pathway antibodies	Vesicle-mediated Transport Pathway Diagram

Diseases associated with BIN1 recombinant protein

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>123 publications with BIN1 and Nervous System Diseases
Alzheimer Disease Antibodies	>98 publications with BIN1 and Alzheimer Disease
Brain Diseases Antibodies	>91 publications with BIN1 and Brain Diseases
Myopathies, Structural, Congenital Antibodies	>27 publications with BIN1 and Myopathies, Structural, Congenital
MYOPATHY, CENTRONUCLEAR, 2 Antibodies	>26 publications with BIN1 and MYOPATHY, CENTRONUCLEAR, 2
Cell Transformation, Neoplastic Antibodies	>18 publications with BIN1 and Cell Transformation, Neoplastic
Heart Diseases Antibodies	>14 publications with BIN1 and Heart Diseases
Breast Neoplasms Antibodies	>12 publications with BIN1 and Breast Neoplasms
Disease Models, Animal Antibodies	>12 publications with BIN1 and Disease Models, Animal
Cognition Disorders Antibodies	>10 publications with BIN1 and Cognition Disorders

Organs/Tissues associated with BIN1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Muscle Antibodies	>71 publications with BIN1 and Muscle
Nerve Antibodies	>69 publications with BIN1 and Nerve
Brain Antibodies	>62 publications with BIN1 and Brain
Heart Antibodies	>25 publications with BIN1 and Heart
Blood Antibodies	>17 publications with BIN1 and Blood
Prostate Antibodies	>8 publications with BIN1 and Prostate
Liver Antibodies	>7 publications with BIN1 and Liver
Embryonic Tissue Antibodies	>7 publications with BIN1 and Embryonic Tissue
Bone Antibodies	>6 publications with BIN1 and Bone
Lymph Node Antibodies	>5 publications with BIN1 and Lymph Node