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Mitochondrial Carrier Protein MTM1 (MTM1) Saccharomyces Cerevisiae Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1028615

MBS1028615 is a recombinant protein targeting MTM1. Also known as Recombinant Saccharomyces cerevisiae Mitochondrial carrier protein MTM1 (MTM1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Mitochondrial carrier protein MTM1 (MTM1), Recombinant Protein
Full Product Name
Recombinant Saccharomyces cerevisiae Mitochondrial carrier protein MTM1 (MTM1)
Product Gene Name
MTM1 recombinant protein
Product Synonym Gene Name
MTM1
Product Synonym Names
Recombinant Mitochondrial carrier protein MTM1 (MTM1); Mitochondrial carrier protein MTM1; Manganese trafficking factor for mitochondrial SOD2
Sequence
MSDRNTSNSL TLKERMLSAG AGSVLTSLIL TPMDVVRIRL QQQQMIPDCS CDGAAEVPNA VSSGSKMKTF TNVGGQNLNN AKIFWESACF QELHCKNSSL KFNGTLEAFT KIASVEGITS LWRGISLTLL MAIPANMVYF SGYEYIRDVS PIASTYPTLN PLFCGAIARV FAATSIAPLE LVKTKLQSIP RSSKSTKTWM MVKDLLNETR QEMKMVGPSR ALFKGLEITL WRDVPFSAIY WSSYELCKER LWLDSTRFAS KDANWVHFIN SFASGCISGM IAAICTHPFD VGKTRWQISM MNNSDPKGGN RSRNMFKFLE TIWRTEGLAA LYTGLAARVI KIRPSCAIMI SSYEISKKVF GNKLHQ
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
Molecular Weight
40,763 Da
Sequence Positions
1-366
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Chromosome Location
Chromosome: VII; NC_001139.9 (1006205..1007305, complement). Location: chromosome: VII
3D Structure
ModBase 3D Structure for P53320
Species
Saccharomyces cerevisiae (strain 204508 / S288c) (Baker's yeast)
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of MTM1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MTM1. It may not necessarily be applicable to this product.

NCBI GI #
398366325
NCBI GeneID
853173
NCBI Accession #
NP_011773.3
UniProt Primary Accession #
P53320
UniProt Secondary Accession #
D6VV37
UniProt Related Accession #
P53320
GenBank Nucleotide #
NM_001181386.3
NCBI Official Full Name
Mtm1p
NCBI Official Symbol
MTM1
UniProt Protein Name
Mitochondrial carrier protein MTM1
UniProt Synonym Protein Names
Manganese trafficking factor for mitochondrial SOD2
Protein Family
Mitochondrial carrier protein
UniProt Gene Name
MTM1
UniProt Entry Name
MTM1_YEAST
NCBI Protein Information
Mtm1p

UniProt Comments for MTM1

Function: Involved in the mitochondrial activation of SOD2 by specifically facilitating insertion of the essential manganese cofactor. Has the ability to activate iron regulon in an iron-dependent manner. Responds to calorie restriction (CR) strength. Ref.5 Ref.7 Ref.8

Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein

Potential Ref.5.

Disruption phenotype: Loss of mitochondrial manganese superoxide dismutase SOD2 activity due to misincorporation of iron into SOD2 rather than manganese. Normal SOD2 activity when in association with YFH1 deletion. Doesn't impair activity of a cytosolic version of manganese SOD. The iron regulatory transcription factor AFT1 is constitutively active. Accumulates mtDNA mutations. Elevated mitochondrial iron and manganese levels. Ref.5 Ref.6

Miscellaneous: Present with 538 molecules/cell in log phase SD medium.

Sequence similarities: Belongs to the mitochondrial carrier family.Contains 3 Solcar repeats.
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Research Articles on MTM1

1. transposon insertions in two genes were able to rescue the growth defect resulting from MTM1 deletion on nonfermentable carbon source.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with MTM1 recombinant protein

 Reference Product  PubMed Publications
 SOD2 recombinant protein  >5 publications with MTM1 and SOD2
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