• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Lathosterol Oxidase (SC5DL) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1030788

MBS1030788 is a recombinant protein targeting SC5DL. Also known as Recombinant Human Lathosterol oxidase (SC5DL). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

Please Inquire
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Lathosterol oxidase (SC5DL), Recombinant Protein
Full Product Name
Recombinant Human Lathosterol oxidase (SC5DL)
Product Gene Name
SC5DL recombinant protein
Product Synonym Gene Name
SC5DL
Product Synonym Names
Recombinant Lathosterol oxidase (SC5DL); Lathosterol oxidase EC= 1.14.21.6; C-5 sterol desaturase Delta(7)-sterol 5-desaturase Lathosterol 5-desaturase Sterol-C5-desaturase
Sequence
MDLVLRVADY YFFTPYVYPA TWPEDDIFRQ AISLLIVTNV GAYILYFFCA TLSYYFVFDH ALMKHPQFLK NQVRREIKFT VQALPWISIL TVALFLLEIR GYSKLHDDLG EFPYGLFELV VSIISFLFFT DMFIYWIHRG LHHRLVYKRL HKPHHIWKIP TPFASHAFHP IDGFLQSLPY HIYPFIFPLH KVVYLSLYIL VNIWTISIHD GDFRVPQILQ PFINGSAHHT DHHMFFDYNY GQYFTLWDRI GGSFKNPSSF EGKGPLSYVK EMTEGKRSSH SGNGCKNEKL FNGEFTKTE
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
Molecular Weight
35,301 Da
Sequence Positions
1-299
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Chromosome Location
Chromosome: 11; NC_000011.9 (121163388..121184119). Location: 11q23.3
OMIM
602286
3D Structure
ModBase 3D Structure for O75845
Species
Homo sapiens (Human)
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of SC5DL recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SC5DL. It may not necessarily be applicable to this product.

NCBI GI #
68160945
NCBI GeneID
6309
NCBI Accession #
NP_001020127.1
UniProt Primary Accession #
O75845
UniProt Secondary Accession #
O00119; Q9UK15
UniProt Related Accession #
O75845
GenBank Nucleotide #
NM_001024956.2
NCBI Official Full Name
lathosterol oxidase
NCBI Official Synonym Full Names
sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S. cerevisiae)-like
NCBI Official Symbol
SC5DL
NCBI Official Synonym Symbols
ERG3; SC5D; S5DES
UniProt Protein Name
Lathosterol oxidase
UniProt Synonym Protein Names
C-5 sterol desaturase; Delta(7)-sterol 5-desaturase; Lathosterol 5-desaturase; Sterol-C5-desaturase
UniProt Gene Name
SC5DL
UniProt Entry Name
SC5D_HUMAN
NCBI Protein Information
lathosterol oxidase; C-5 sterol desaturase; lathosterol 5-desaturase; lathosterol dehydrogenase; delta(7)-sterol 5-desaturase; fungal ERG3, delta-5-desaturase-like; 3beta-hydroxysteroid-delta5-desaturase

NCBI Summary for SC5DL

This gene encodes an enzyme of cholesterol biosynthesis. The encoded protein catalyzes the conversion of lathosterol into 7-dehydrocholesterol. Mutations in this gene have been associated with lathosterolosis. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
Show more

UniProt Comments for SC5DL

SC5DL: Catalyzes a dehydrogenation to introduce C5-6 double bond into lathosterol. Defects in SC5DL are the cause of lathosterolosis (LATHST). This autosomal recessive disorder is characterized by a complex phenotype, including multiple congenital anomalies, mental retardation, and liver disease. Belongs to the sterol desaturase family.

Protein type: Lipid Metabolism - steroid biosynthesis; EC 1.14.21.6; Membrane protein, multi-pass; Membrane protein, integral; Oxidoreductase

Chromosomal Location of Human Ortholog: 11q23.3

Cellular Component: endoplasmic reticulum membrane; integral to membrane

Molecular Function: C-5 sterol desaturase activity; lathosterol oxidase activity; iron ion binding

Biological Process: cholesterol biosynthetic process via lathosterol; lipid metabolic process; cholesterol biosynthetic process; fatty acid biosynthetic process

Disease: Lathosterolosis
Show more

Research Articles on SC5DL

1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with SC5DL recombinant protein

 Products by Pathway  Pathway Diagram
 Cholesterol Biosynthesis Pathway antibodies  Cholesterol Biosynthesis Pathway Diagram
 Cholesterol Biosynthesis Pathway antibodies  Cholesterol Biosynthesis Pathway Diagram
 Cholesterol Biosynthesis, Squalene 2,3-epoxide => Cholesterol Pathway antibodies  Cholesterol Biosynthesis, Squalene 2,3-epoxide => Cholesterol Pathway Diagram
 Cholesterol Biosynthesis, Squalene 2,3-epoxide => Cholesterol Pathway antibodies  Cholesterol Biosynthesis, Squalene 2,3-epoxide => Cholesterol Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Steroid Biosynthesis Pathway antibodies  Steroid Biosynthesis Pathway Diagram
 Steroid Biosynthesis Pathway antibodies  Steroid Biosynthesis Pathway Diagram
 Cholesterol Biosynthesis I Pathway antibodies  Cholesterol Biosynthesis I Pathway Diagram
 Cholesterol Biosynthesis I Pathway antibodies  Cholesterol Biosynthesis I Pathway Diagram

Diseases associated with SC5DL recombinant protein

 Disease Name  Pubmed Publications
 Abnormalities, Drug-Induced Antibodies  >1 publications with SC5DL and Abnormalities, Drug-Induced

Organs/Tissues associated with SC5DL recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Intestine Antibodies  >1 publications with SC5DL and Intestine
 Blood Antibodies  >1 publications with SC5DL and Blood
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000