Human NKRF Recombinant Protein – Cat# MBS1031964

Nf-Kappa-B-Repressing Factor (NKRF) Human Recombinant Protein

Name: NKRF Recombinant Protein; Nf-Kappa-B-Repressing Factor; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1031964
Price: 455 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1031964

Interacts with a specific negative regulatory elent (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes. Involved in the constitutive silencing of the interferon beta promoter, independently of the… More details

$455 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

NF-kappa-B-repressing factor (NKRF), Recombinant Protein

Full Product Name

Recombinant Human NF-kappa-B-repressing factor (NKRF)

Product Gene Name

NKRF recombinant protein

Product Synonym Gene Name

NKRF; ITBA4; NRF

Product Synonym Names

NF-kappa-B-repressing factor; NFkB-repressing factor; Protein ITBA4; Transcription factor NRF

Sequence

ILQMAEGIDI GEMPSYDLVL SKPSKGQKRH LSTCDGQNPP KKQAGSKFHA RPRFEPVHFV ASSSKDERQE DPYGPQTKEV NEQTHFASMP RDIYQDYTQD SFSIQDGNSQ YCDSSGFILT KDQPVTANMY FDSGNPAPST TSQQANSQST PEPSPSQTFP ESVVAEKQYF IEKLTATIWK NLSNPEMTSG SDKINYTYML TRCIQACKTN PEYIYAPLKE IPPADIPKNK KLLTDGYACE VRCQNIYLTT GYAGSKNGSR DRATELAVKL LQKRIEVRVV RRKFKHTFGE DLVVCQIGMS SYEFPPALKP PEDLVVLGKD ASGQPIFNAS AKHWTNFVIT ENANDAIGIL NNSASFNKMS IEYKYEMMPN RTWRCRVFLQ DHCLAEGYGT KKTSKHAAAD EALKILQKTQ PTYPSVKSSQ CHTGSSPRGS GKKKDIKDLV VYENSSNPVC TLNDTAQFNR MTVEYVYERM TGLRWKCKVI LESEVIAEAV GVKKTVKYEA AGEAVKTLKK TQPTVINNLK KGAVEDVISR NEIQGRSAEE AYKQQIKEDN IGNQLLRKMG WTGGGLGKSG EGIREPISVK EQHKREGLGL DVERVNKIAK RDIEQIIRNY ARSESHTDLT FSRELTNDER KQIHQIAQKY GLKSKSHGVG HDRYLVVGRK RRKEDLLDQL KQEGQVGHYE LVMPQ

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

81.1 kDa

Sequence Positions

4-688aa; Partial

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

300440

3D Structure

ModBase 3D Structure for O15226

Species

Homo sapiens (Human)

Product Categories/Family for NKRF recombinant protein

Cell Biology

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of NKRF recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NKRF purchase

MBS1031964 is a recombinant protein targeting NKRF. Also known as Recombinant Human NF-kappa-B-repressing factor (NKRF). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for NKRF. It may not necessarily be applicable to this product.

NCBI GI #

291084505

NCBI GeneID

55922

NCBI Accession #

NP_001166958.1

UniProt Primary Accession #

O15226

UniProt Secondary Accession #

Q4VC41; Q9UJ91; G3V1N1

UniProt Related Accession #

O15226

GenBank Nucleotide #

NM_001173487.1

NCBI Official Full Name

NF-kappa-B-repressing factor isoform 1

NCBI Official Synonym Full Names

NFKB repressing factor

NCBI Official Symbol

NKRF

NCBI Official Synonym Symbols

NRF; ITBA4

UniProt Protein Name

NF-kappa-B-repressing factor

UniProt Synonym Protein Names

Protein ITBA4; Transcription factor NRF

Protein Family

NF-kappa-B-repressing factor

UniProt Gene Name

NKRF

UniProt Synonym Gene Names

ITBA4; NRF; NFkB-repressing factor

UniProt Entry Name

NKRF_HUMAN

NCBI Protein Information

NF-kappa-B-repressing factor; transcription factor NRF

NCBI Summary for NKRF

This gene encodes a transcriptional repressor that interacts with specific negative regulatory elements to mediate transcriptional repression of certain nuclear factor kappa B responsive genes. The protein localizes predominantly to the nucleolus with a small fraction found in the nucleoplasm and cytoplasm. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

UniProt Comments for NKRF

NKRF: Interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes. Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity. Also involved in the regulation of IL-8 transcription.

Protein type: Nucleolus; Transcription, coactivator/corepressor; RNA-binding

Chromosomal Location of Human Ortholog: Xq24

Cellular Component: endoplasmic reticulum; nucleolus; nucleus

Molecular Function: protein binding; DNA binding

Biological Process: transcription, DNA-dependent; negative regulation of transcription, DNA-dependent

Research Articles on NKRF

1. NRF may serve as an endogenous repressor to prevent robust increase in IP-10/CXCL10 and IL-8/CXCL8 when TB bacterial load is high.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with NKRF recombinant protein

Reference Product	PubMed Publications
RELA recombinant protein	>2 publications with NKRF and RELA
REL recombinant protein	>2 publications with NKRF and REL

Diseases associated with NKRF recombinant protein

Disease Name	Pubmed Publications
Necrosis Antibodies	>5 publications with NKRF and Necrosis
Inflammation Antibodies	>5 publications with NKRF and Inflammation
Pain Antibodies	>1 publications with NKRF and Pain
Fever Antibodies	>1 publications with NKRF and Fever
Nervous System Diseases Antibodies	>1 publications with NKRF and Nervous System Diseases
Diarrhea Antibodies	>1 publications with NKRF and Diarrhea

Organs/Tissues associated with NKRF recombinant protein

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>5 publications with NKRF and Lung
Brain Antibodies	>3 publications with NKRF and Brain
Bone Antibodies	>1 publications with NKRF and Bone
Pancreas Antibodies	>1 publications with NKRF and Pancreas
Skin Antibodies	>1 publications with NKRF and Skin
Muscle Antibodies	>1 publications with NKRF and Muscle
Kidney Antibodies	>1 publications with NKRF and Kidney