Human KCNH1 Recombinant Protein – Cat# MBS1033401

Potassium Voltage-Gated Channel Subfamily H Member 1 (KCNH1) Human Recombinant Protein

Name: KCNH1 Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1033401
Price: 1895 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1033401

MBS1033401 is a recombinant protein targeting KCNH1. Also known as Recombinant Human Potassium voltage-gated channel subfamily H member 1 (KCNH1) , partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$1895 / 1 mg (E-Coli) +2 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Potassium voltage-gated channel subfamily H member 1 (KCNH1), Recombinant Protein

Full Product Name

Recombinant Human Potassium voltage-gated channel subfamily H member 1 (KCNH1) , partial

Product Gene Name

KCNH1 recombinant protein

Sequence

MTMAGGRRGL VAPQNTFLEN IVRRSNDTNF VLGNAQIVDW PIVYSNDGFC KLSGYHRAEV MQKSSTCSFM YGELTDKDTI EKVRQTFENY EMNSFEILMY KKNRTPVWFF VKIAPIRNEQ DKVVLFLCTF SDITAFKQPI EDDSCKGWGK FARLTRALTS SRGVLQQLAP SVQKGENVHK HSRLAEVLQL GSDILPQYKQ EAPKTPPHII LHYCVFKTTW DWIILILTFY TAILVPYNVS FKTRQNNVAW LVVDSIVDVI FLVDIVLNFH TTFVGPAGEV ISDPKLIRMN YLKTWFVIDL LSCLPYDVIN AFENVDEVSA FMGDPGKIGF ADQIPPPLEG RESQGISSLF SSLKVVRLLR LGRVARKLDH YIEYGAAVLV LLVCVFGLAA HWMACIWYSI GDYEIFDEDT KTIRNNSWLY QLAMDIGTPY QFNGSGSGKW EGGPSKNSVY ISSLYFTMTS LTSVGFGNIA PSTDIEKIFA VAIMMIGSLL YATIFGNVTT IFQQMYANTN RYHEMLNSVR DFLKLYQVPK GLSERVMDYI VSTWSMSRGI DTEKVLQICP KDMRADICVH LNRKVFKEHP AFRLASDGCL RALAMEFQTV HCAPGDLIYH AGESVDSLCF VVSGSLEVIQ DDEVVAILGK GDVFGDVFWK EATLAQSCAN VRALTYCDLH VIKRDALQKV LEFYTAFSHS FSRNLILTYN LRKRIVFRKI SDVKREEEER MKRKNEAPLI LPPDHPVRRL FQRFRQQKEA RLAAERGGRD LDDLDVEKGN VLTEHASANH SLVKASVVTV RESPATPVSF QAASTSGVPD HAKLQAPGSE CLGPKGGGGD CAKRKSWARF KDACGKSEDW NKVSKAESME TLPERTKASG EATLKKTDSC DSGITKSDLR LDNVGEARSP QDRSPILAEV KHSFYPIPEQ TLQATVLEVR HELKEDIKAL NAKMTNIEKQ LSEILRILTS RRSSQSPQEL FEISRPQSPE SERDIFGAS

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

108,597 Da

Sequence Positions

1-989

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

135500

3D Structure

ModBase 3D Structure for O95259

Species

Homo sapiens (Human)

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of KCNH1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for KCNH1. It may not necessarily be applicable to this product.

NCBI GI #

4504831

NCBI GeneID

3756

NCBI Accession #

NP_002229.1

UniProt Primary Accession #

O95259

UniProt Secondary Accession #

O76035; Q14CL3; B1AQ26

UniProt Related Accession #

O95259

GenBank Nucleotide #

NM_002238.3

NCBI Official Full Name

potassium voltage-gated channel subfamily H member 1 isoform 2

NCBI Official Synonym Full Names

potassium voltage-gated channel subfamily H member 1

NCBI Official Symbol

KCNH1

NCBI Official Synonym Symbols

EAG; EAG1; ZLS1; TMBTS; h-eag; hEAG1; Kv10.1

UniProt Protein Name

Potassium voltage-gated channel subfamily H member 1

UniProt Synonym Protein Names

Ether-a-go-go potassium channel 1

Protein Family

Potassium voltage-gated channel subfamily

UniProt Gene Name

KCNH1

UniProt Synonym Gene Names

; h-eag; hEAG1

NCBI Protein Information

potassium voltage-gated channel subfamily H member 1

NCBI Summary for KCNH1

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. It is activated at the onset of myoblast differentiation. The gene is highly expressed in brain and in myoblasts. Overexpression of the gene may confer a growth advantage to cancer cells and favor tumor cell proliferation. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

UniProt Comments for KCNH1

Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel (PubMed:9738473, PubMed:11943152, PubMed:10880439, PubMed:22732247, PubMed:25556795, PubMed:27325704, PubMed:27005320, PubMed:27618660). Channel properties are modulated by subunit assembly (PubMed:11943152). Mediates IK(NI) current in myoblasts (PubMed:9738473). Involved in the regulation of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs) (PubMed:23881642).

Research Articles on KCNH1

1. A role of Kv10.1 in coordinating primary cilium disassembly with cell cycle progression through localized changes of membrane potential at the ciliary base is proposed [REVIEW].

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with KCNH1 recombinant protein

Reference Product	PubMed Publications
KCNH5 recombinant protein	>10 publications with KCNH1 and KCNH5

Pathways associated with KCNH1 recombinant protein

Products by Pathway	Pathway Diagram
Neuronal System Pathway antibodies	Neuronal System Pathway Diagram
Potassium Channels Pathway antibodies	Potassium Channels Pathway Diagram
Voltage Gated Potassium Channels Pathway antibodies	Voltage Gated Potassium Channels Pathway Diagram

Diseases associated with KCNH1 recombinant protein

Disease Name	Pubmed Publications
Arrhythmias, Cardiac Antibodies	>25 publications with KCNH1 and Arrhythmias, Cardiac
Long QT Syndrome Antibodies	>22 publications with KCNH1 and Long QT Syndrome
Neoplasm Invasiveness Antibodies	>8 publications with KCNH1 and Neoplasm Invasiveness
Breast Neoplasms Antibodies	>8 publications with KCNH1 and Breast Neoplasms
Ventricular Dysfunction Antibodies	>3 publications with KCNH1 and Ventricular Dysfunction
Liver Diseases Antibodies	>3 publications with KCNH1 and Liver Diseases
Torsades de Pointes Antibodies	>3 publications with KCNH1 and Torsades de Pointes
Ventricular Fibrillation Antibodies	>3 publications with KCNH1 and Ventricular Fibrillation
Poisoning Antibodies	>3 publications with KCNH1 and Poisoning
Necrosis Antibodies	>2 publications with KCNH1 and Necrosis

Organs/Tissues associated with KCNH1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>24 publications with KCNH1 and Brain
Mammary Gland Antibodies	>1 publications with KCNH1 and Mammary Gland
Testis Antibodies	>1 publications with KCNH1 and Testis
Pituitary Gland Antibodies	>1 publications with KCNH1 and Pituitary Gland