Human GRM8 Recombinant Protein – Cat# MBS1034005

Metabotropic Glutamate Receptor 8 (GRM8) Human Recombinant Protein

Name: GRM8 Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1034005
Price: 1895 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1034005

MBS1034005 is a recombinant protein targeting GRM8. Also known as Recombinant Human Metabotropic glutamate receptor 8 (GRM8) , partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$1895 / 1 mg (E-Coli) +2 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Metabotropic glutamate receptor 8 (GRM8), Recombinant Protein

Full Product Name

Recombinant Human Metabotropic glutamate receptor 8 (GRM8) , partial

Product Gene Name

GRM8 recombinant protein

Sequence

QEYAHSIRVD GDIILGGLFP VHAKGERGVP CGELKKEKGI HRLEAMLYAI DQINKDPDLL SNITLGVRIL DTCSRDTYAL EQSLTFVQAL IEKDASDVKC ANGDPPIFTK PDKISGVIGA AASSVSIMVA NILRLFKIPQ ISYASTAPEL SDNTRYDFFS RVVPPDSYQA QAMVDIVTAL GWNYVSTLAS EGNYGESGVE AFTQISREIG GVCIAQSQKI PREPRPGEFE KIIKRLLETP NARAVIMFAN EDDIRRILEA AKKLNQSGHF LWIGSDSWGS KIAPVYQQEE IAEGAVTILP KRASIDGFDR YFRSRTLANN RRNVWFAEFW EENFGCKLGS HGKRNSHIKK CTGLERIARD SSYEQEGKVQ FVIDAVYSMA YALHNMHKDL CPGYIGLCPR MSTIDGKELL GYIRAVNFNG SAGTPVTFNE NGDAPGRYDI FQYQITNKST EYKVIGHWTN QLHLKVEDMQ WAHREHTHPA SVCSLPCKPG ERKKTVKGVP CCWHCERCEG YNYQVDELSC ELCPLDQRPN MNRTGCQLIP IIKLEWHSPW AVVPVFVAIL GIIATTFVIV TFVRYNDTPI VRASGRELSY VLLTGIFLCY SITFLMIAAP DTIICSFRRV FLGLGMCFSY AALLTKTNRI HRIFEQGKKS VTAPKFISPA SQLVITFSLI SVQLLGVFVW FVVDPPHIII DYGEQRTLDP EKARGVLKCD ISDLSLICSL GYSILLMVTC TVYAIKTRGV PETFNEAKPI GFTMYTTCII WLAFIPIFFG TAQSAEKMYI QTTTLTVSMS LSASVSLGML YMPKVYIIIF HPEQNVQKRK RSFKAVVTAA TMQSKLIQKG NDRPNGEVKS ELCESLETNT SSTKTTYISY SNHSI

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

55,948 Da

Sequence Positions

34-908

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

601116

3D Structure

ModBase 3D Structure for O00222

Species

Homo sapiens (Human)

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of GRM8 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for GRM8. It may not necessarily be applicable to this product.

NCBI GI #

187960067

NCBI GeneID

2918

NCBI Accession #

NP_000836.2

UniProt Primary Accession #

O00222

UniProt Secondary Accession #

O15493; O95945; O95946; Q3MIV9; Q52M02; Q6J165; A4D0Y3; B0FZ74; B0M0L0

UniProt Related Accession #

O00222

GenBank Nucleotide #

NM_000845.2

NCBI Official Full Name

metabotropic glutamate receptor 8 isoform a

NCBI Official Synonym Full Names

glutamate metabotropic receptor 8

NCBI Official Symbol

GRM8

NCBI Official Synonym Symbols

GLUR8; mGlu8; GPRC1H; MGLUR8

UniProt Protein Name

Metabotropic glutamate receptor 8

Protein Family

Metabotropic glutamate receptor

UniProt Gene Name

GRM8

UniProt Synonym Gene Names

GPRC1H; MGLUR8; mGluR8

NCBI Protein Information

metabotropic glutamate receptor 8

NCBI Summary for GRM8

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

UniProt Comments for GRM8

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.

Research Articles on GRM8

1. This study showed that GRM8 was nominally associated (p < 0.05) with both delta measures (energy and intertrial phase coherence).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with GRM8 recombinant protein

Products by Pathway	Pathway Diagram
Class C/3 (Metabotropic Glutamate/pheromone Receptors) Pathway antibodies	Class C/3 (Metabotropic Glutamate/pheromone Receptors) Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
GPCRs, Class C Metabotropic Glutamate, Pheromone Pathway antibodies	GPCRs, Class C Metabotropic Glutamate, Pheromone Pathway Diagram
GPCRs, Other Pathway antibodies	GPCRs, Other Pathway Diagram
Glutamatergic Synapse Pathway antibodies	Glutamatergic Synapse Pathway Diagram
Glutamatergic Synapse Pathway antibodies	Glutamatergic Synapse Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram
Signal Transduction Pathway antibodies	Signal Transduction Pathway Diagram
Signaling By GPCR Pathway antibodies	Signaling By GPCR Pathway Diagram

Diseases associated with GRM8 recombinant protein

Disease Name	Pubmed Publications
Mental Disorders Antibodies	>7 publications with GRM8 and Mental Disorders
Personality Disorders Antibodies	>1 publications with GRM8 and Personality Disorders
Cognition Disorders Antibodies	>1 publications with GRM8 and Cognition Disorders
Autistic Disorder Antibodies	>1 publications with GRM8 and Autistic Disorder
Attention Deficit Disorder with Hyperactivity Antibodies	>1 publications with GRM8 and Attention Deficit Disorder with Hyperactivity

Organs/Tissues associated with GRM8 recombinant protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>3 publications with GRM8 and Brain
Lung Antibodies	>1 publications with GRM8 and Lung