Interleukin 1beta Precursor (PRO-IL-1beta) ELISA Kit for Donkey

This gene encodes a protein that is a member of the integrin superfamily. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein undergoes post-translational cleavage to yield disulfide-linked heavy and light chains that combine with multiple integrin beta chains to form different integrins. This protein has been shown to heterodimerize with beta 1, beta 3, beta 5, beta 6, and beta 8; the heterodimer of alpha v and beta 3 is the Vitronectin receptor. This protein interacts with several extracellular matrix proteins to mediate cell adhesion and may play a role in cell migration. It is proposed that this protein may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, May 2013]

ITGAV: The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. Belongs to the integrin alpha chain family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 2q31-q32

Cellular Component: filopodium membrane; focal adhesion; cell surface; membrane; integral to plasma membrane; microvillus membrane; plasma membrane; phagocytic vesicle; integrin complex; external side of plasma membrane

Molecular Function: viral receptor activity; voltage-gated calcium channel activity; opsonin binding; protein binding; insulin-like growth factor I binding; protein kinase C binding; protease binding; extracellular matrix binding; transforming growth factor beta binding; metal ion binding; fibronectin binding

Biological Process: integrin-mediated signaling pathway; negative regulation of lipid transport; axon guidance; extracellular matrix organization and biogenesis; cell migration; entry of virus into host cell; positive regulation of cell adhesion; negative regulation of lipoprotein metabolic process; cell-matrix adhesion; negative chemotaxis; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; entry of symbiont into host cell by promotion of host phagocytosis; regulation of phagocytosis; cell-substrate adhesion; heterotypic cell-cell adhesion; antigen processing and presentation of peptide antigen via MHC class I; negative regulation of low-density lipoprotein receptor biosynthetic process; positive regulation of osteoblast proliferation; positive regulation of cell proliferation; antigen processing and presentation of exogenous peptide antigen via MHC class I; angiogenesis; vascular endothelial growth factor receptor signaling pathway; cell adhesion; blood coagulation; cell growth; leukocyte migration; apoptotic cell clearance; positive regulation of cell migration