Human FAIM3 Recombinant Protein – Cat# MBS1040717

Fas Apoptotic Inhibitory Molecule 3 (FAIM3) Human Recombinant Protein

Name: FAIM3 Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1040717
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1040717

MBS1040717 is a recombinant protein targeting FAIM3. Also known as Recombinant Human Fas apoptotic inhibitory molecule 3 (FAIM3). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. FAIM3; TOSO More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Fas apoptotic inhibitory molecule 3 (FAIM3), Recombinant Protein

Full Product Name

Recombinant Human Fas apoptotic inhibitory molecule 3 (FAIM3)

Product Gene Name

FAIM3 recombinant protein

Product Synonym Gene Name

FAIM3; TOSO

Product Synonym Names

Fas apoptotic inhibitory molecule 3; Regulator of Fas-induced apoptosis Toso

Sequence

RIL PEVKVEGELG GSVTIKCPLP EMHVRIYLCR EMAGSGTCGT VVSTTNFIKA EYKGRVTLKQ YPRKNLFLVE VTQLTESDSG VYACGAGMNT DRGKTQKVTL NVHSEYEPSW EEQPMPETPK WFHLPYLFQM PAYASSSKFV TRVTTPAQRG KVPPVHHSSP TTQITHRPRV SRASSVAGDK PRTFLPSTTA SKISALEGLL KPQTPSYNHH TRLHRQRALD YGSQSGREGQ G

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

33,828 Da

Sequence Positions

18-251

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

606015

3D Structure

ModBase 3D Structure for O60667

Species

Homo sapiens (Human)

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of FAIM3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for FAIM3. It may not necessarily be applicable to this product.

NCBI GI #

216547554

NCBI GeneID

9214

NCBI Accession #

NP_001135945.1

UniProt Primary Accession #

O60667

UniProt Secondary Accession #

A8K7J2; B7Z6Z0; D9MWM3

UniProt Related Accession #

O60667

GenBank Nucleotide #

NM_001142473.1

NCBI Official Full Name

fas apoptotic inhibitory molecule 3 isoform b

NCBI Official Synonym Full Names

Fas apoptotic inhibitory molecule 3

NCBI Official Symbol

FAIM3

NCBI Official Synonym Symbols

FCMR; TOSO

UniProt Protein Name

Fas apoptotic inhibitory molecule 3

UniProt Synonym Protein Names

Regulator of Fas-induced apoptosis Toso

UniProt Gene Name

FAIM3

UniProt Synonym Gene Names

TOSO

UniProt Entry Name

FAIM3_HUMAN

NCBI Protein Information

fas apoptotic inhibitory molecule 3; Fc mu receptor; IgM Fc receptor; immunoglobulin mu Fc receptor; regulator of Fas-induced apoptosis Toso

NCBI Summary for FAIM3

Fc receptors specifically bind to the Fc region of immunoglobulins (Igs) to mediate the unique functions of each Ig class. FAIM3 encodes an Fc receptor for IgM (see MIM 147020) (Kubagawa et al., 2009 [PubMed 19858324]; Shima et al., 2010 [PubMed 20042454]).[supplied by OMIM, Jul 2010]

UniProt Comments for FAIM3

FAIM3: May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Apoptosis

Chromosomal Location of Human Ortholog: 1q32.1

Cellular Component: extracellular region; integral to membrane

Biological Process: immune system process; cellular defense response; negative regulation of apoptosis

Research Articles on FAIM3

1. Overexpression of TOSO gene is associated with chronic lymphocytic leukemia.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with FAIM3 recombinant protein

Reference Product	PubMed Publications
CD19 recombinant protein	>1 publications with FAIM3 and CD19

Diseases associated with FAIM3 recombinant protein

Disease Name	Pubmed Publications
Liver Diseases Antibodies	>1 publications with FAIM3 and Liver Diseases
Demyelinating Diseases Antibodies	>1 publications with FAIM3 and Demyelinating Diseases
Disease Models, Animal Antibodies	>1 publications with FAIM3 and Disease Models, Animal
Inflammation Antibodies	>1 publications with FAIM3 and Inflammation
Necrosis Antibodies	>1 publications with FAIM3 and Necrosis

Organs/Tissues associated with FAIM3 recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>12 publications with FAIM3 and Blood
Liver Antibodies	>1 publications with FAIM3 and Liver
Placenta Antibodies	>1 publications with FAIM3 and Placenta
Spleen Antibodies	>1 publications with FAIM3 and Spleen
Lung Antibodies	>1 publications with FAIM3 and Lung