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Fractalkine (CX3CL1) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1045852

MBS1045852 is a recombinant protein targeting Cx3cl1. Also known as Recombinant Mouse Fractalkine (Cx3cl1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Fractalkine (Cx3cl1), Recombinant Protein
Full Product Name
Recombinant Mouse Fractalkine (Cx3cl1)
Product Gene Name
Cx3cl1 recombinant protein
Product Synonym Gene Name
Cx3cl1; Cx3c; Fkn; Scyd1
Product Synonym Names
Fractalkine; C-X3-C motif chemokine 1; CX3C membrane-anchored chemokine; Neurotactin; Small-inducible cytokine D1Cleaved into the following chain:; 1. Processed fractalkine
Sequence
QHLGMT KCEIMCDKMT SRIPVALLIR YQLNQESCGK RAIVLETTQH RRFCADPKEK WVQDAMKHLD HQAAALTKNG GKFEKRVDNV TPGITLATRG LSPSALTKPE SATLEDLALE LTTISQEARG TMGTSQEPPA AVTGSSLSTS EAQDAGLTAK PQSIGSFEAA DISTTVWPSP AVYQSGSSSW AEEKATESPS TTAPSPQVST TSPSTPEENV GSEGQPPWVQ GQDLSPEKSL GSEEINPVHT DNFQERGPGN TVHPSVAPIS SEETPSPELV ASGSQAPKIE EPIHATADPQ KLSVLITPVP DTQAAT
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
42,099 Da
Sequence Positions
25-336
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for O35188
Species
Mus musculus (Mouse)
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Cx3cl1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Cx3cl1. It may not necessarily be applicable to this product.

NCBI GI #
31982017
NCBI GeneID
20312
NCBI Accession #
NP_033168.2
UniProt Primary Accession #
O35188
UniProt Secondary Accession #
O35933; Q91V44
UniProt Related Accession #
O35188
GenBank Nucleotide #
NM_009142.3
NCBI Official Full Name
fractalkine
NCBI Official Synonym Full Names
chemokine (C-X3-C motif) ligand 1
NCBI Official Symbol
Cx3cl1
NCBI Official Synonym Symbols
CX3C; Cxc3; Scyd1; ABCD-3; AB030188; AI848747; D8Bwg0439e
UniProt Protein Name
Fractalkine
UniProt Synonym Protein Names
C-X3-C motif chemokine 1; CX3C membrane-anchored chemokine; Neurotactin; Small-inducible cytokine D1Cleaved into the following chain:Processed fractalkine
Protein Family
Fractalkine
UniProt Gene Name
Cx3cl1
UniProt Synonym Gene Names
Cx3c; Fkn; Scyd1
UniProt Entry Name
X3CL1_MOUSE
NCBI Protein Information
fractalkine; neurotactin; C-X3-C motif chemokine 1; small-inducible cytokine D1; CX3C membrane-anchored chemokine; small inducible cytokine subfamily D, 1

UniProt Comments for Cx3cl1

CX3CL1: The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium. Binds to CX3CR1. Belongs to the intercrine delta family.

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral

Cellular Component: extracellular space; cell projection; cell surface; membrane; perinuclear region of cytoplasm; cytoplasm; plasma membrane; integral to membrane; extracellular region

Molecular Function: chemokine activity; cytokine activity

Biological Process: platelet activation; positive regulation of neuroblast proliferation; neutrophil chemotaxis; positive regulation of transforming growth factor-beta1 production; positive regulation of cell adhesion; wound healing; positive regulation of smooth muscle cell proliferation; cytokine and chemokine mediated signaling pathway; negative regulation of cytokine secretion; microglial cell activation; angiogenesis involved in wound healing; chemotaxis; macrophage chemotaxis; leukocyte adhesive activation; negative regulation of vasoconstriction; regulation of inhibitory postsynaptic membrane potential; positive regulation of angiogenesis; positive regulation of calcium-independent cell-cell adhesion; immune response; cell adhesion; lymphocyte chemotaxis; positive regulation of cell migration
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Research Articles on Cx3cl1

1. our data suggest that the CX3CR1/ CX3CL1 pathway is involved in the recruitment of circulating CD16 thorn CX3CR1 thorn monocytes to the periprosthetic tissues.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Cx3cl1 recombinant protein

 Reference Product  PubMed Publications
 CX3CR1 recombinant protein  >322 publications with Cx3cl1 and CX3CR1

Pathways associated with Cx3cl1 recombinant protein

 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram

Diseases associated with Cx3cl1 recombinant protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >319 publications with Cx3cl1 and Inflammation
 Necrosis Antibodies  >172 publications with Cx3cl1 and Necrosis
 Cardiovascular Diseases Antibodies  >137 publications with Cx3cl1 and Cardiovascular Diseases
 Brain Diseases Antibodies  >89 publications with Cx3cl1 and Brain Diseases
 Atherosclerosis Antibodies  >84 publications with Cx3cl1 and Atherosclerosis
 Pain Antibodies  >55 publications with Cx3cl1 and Pain
 Kidney Diseases Antibodies  >54 publications with Cx3cl1 and Kidney Diseases
 Liver Diseases Antibodies  >45 publications with Cx3cl1 and Liver Diseases
 Heart Diseases Antibodies  >44 publications with Cx3cl1 and Heart Diseases
 Myocardial Ischemia Antibodies  >37 publications with Cx3cl1 and Myocardial Ischemia

Organs/Tissues associated with Cx3cl1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >116 publications with Cx3cl1 and Brain
 Kidney Antibodies  >61 publications with Cx3cl1 and Kidney
 Muscle Antibodies  >60 publications with Cx3cl1 and Muscle
 Lung Antibodies  >59 publications with Cx3cl1 and Lung
 Liver Antibodies  >39 publications with Cx3cl1 and Liver
 Heart Antibodies  >33 publications with Cx3cl1 and Heart
 Nerve Antibodies  >33 publications with Cx3cl1 and Nerve
 Skin Antibodies  >30 publications with Cx3cl1 and Skin
 Intestine Antibodies  >23 publications with Cx3cl1 and Intestine
 Embryonic Tissue Antibodies  >19 publications with Cx3cl1 and Embryonic Tissue
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