Mouse SGCE Recombinant Protein – Cat# MBS1046163

Epsilon-Sarcoglycan (SGCE) Mouse Recombinant Protein

Name: SGCE Recombinant Protein; Epsilon-Sarcoglycan; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS1046163
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1046163

MBS1046163 is a recombinant protein targeting Sgce. Also known as Recombinant Mouse Epsilon-sarcoglycan (Sgce). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Epsilon-sarcoglycan (Sgce), Recombinant Protein

Full Product Name

Recombinant Mouse Epsilon-sarcoglycan (Sgce)

Product Gene Name

Sgce recombinant protein

Product Synonym Names

Epsilon-sarcoglycan; Epsilon-SG

Sequence

MLLFWWWELG DPCAWTGKGR GTLKMSPATT GTFLLTVYTL FSKVHSDRNV YPSAGVLFVH VLEREYFKGE FPPYPKPGEV SNDPITFNTN LMGYPDRPGW LRYIQRTPYS DGVLYGSPTA ENVGKPTIIE ITAYNRRTFE TARHNLIINI MSAEEFPLPY QAEFFIKNMN VEEMLASEVL GDFLGAVKNV WQPERLNAIN ITSALDRGGR VPLPINDMKE GVYVMVGADV AFSSCLREVE NPQNQLRCSQ EMEPVITCDK KFRTHFHIDW CKISLVDKTK QVSTYQEVVR GEGILPDGGE YKPPSDSLKS RDYYTDF

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

53,532 Da

Sequence Positions

1-317

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

3D Structure

ModBase 3D Structure for O70258

Species

Mus musculus (Mouse)

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Sgce recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Sgce. It may not necessarily be applicable to this product.

NCBI GI #

194328786

NCBI GeneID

20392

NCBI Accession #

NP_001123660.1

UniProt Primary Accession #

O70258

UniProt Secondary Accession #

Q921G2

UniProt Related Accession #

O70258

GenBank Nucleotide #

NM_001130188.1

NCBI Official Full Name

epsilon-sarcoglycan isoform 1

NCBI Official Synonym Full Names

sarcoglycan, epsilon

NCBI Official Symbol

Sgce

NCBI Official Synonym Symbols

e-SG

UniProt Protein Name

Epsilon-sarcoglycan

Protein Family

Epsilon-sarcoglycan

UniProt Gene Name

Sgce

UniProt Synonym Gene Names

Epsilon-SG

UniProt Entry Name

SGCE_MOUSE

NCBI Protein Information

epsilon-sarcoglycan; epsilon-SG

UniProt Comments for Sgce

SGCE: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. Defects in SGCE are a cause of dystonia type 11 (DYT11); also known as myoclonic dystonia or alcohol- responsive dystonia. DYT11 is a myoclonic dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT11 is characterized by involuntary lightning jerks and dystonic movements and postures alleviated by alcohol. Inheritance is autosomal dominant. The age of onset, pattern of body involvement, presence of myoclonus and response to alcohol are all variable. Belongs to the sarcoglycan alpha/epsilon family.

Protein type: Membrane protein, integral; Cell adhesion

Cellular Component: dystrophin-associated glycoprotein complex; Golgi apparatus; cytoskeleton; cell projection; membrane; integral to plasma membrane; cytoplasm; integral to membrane; plasma membrane; sarcoglycan complex

Molecular Function: protein binding; calcium ion binding

Research Articles on Sgce

1. The results suggest that varepsilon-sarcoglycan in the cerebellar Purkinje cells contributes to the motor learning, while loss of varepsilon-sarcoglycan in other brain regions may contribute to nuclear envelope abnormality, myoclonus and motor coordination deficits.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with Sgce recombinant protein

Disease Name	Pubmed Publications
Myoclonic dystonia Antibodies	>23 publications with Sgce and Myoclonic dystonia
Disease Models, Animal Antibodies	>5 publications with Sgce and Disease Models, Animal
Abnormalities, Multiple Antibodies	>5 publications with Sgce and Abnormalities, Multiple
Liver Diseases Antibodies	>2 publications with Sgce and Liver Diseases
Adenocarcinoma Antibodies	>2 publications with Sgce and Adenocarcinoma
Learning Disorders Antibodies	>2 publications with Sgce and Learning Disorders
Memory Disorders Antibodies	>2 publications with Sgce and Memory Disorders
Prenatal Injuries Antibodies	>1 publications with Sgce and Prenatal Injuries
Fibrosis Antibodies	>1 publications with Sgce and Fibrosis
Abnormalities, Drug-Induced Antibodies	>1 publications with Sgce and Abnormalities, Drug-Induced

Organs/Tissues associated with Sgce recombinant protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>43 publications with Sgce and Brain
Blood Antibodies	>13 publications with Sgce and Blood
Embryonic Tissue Antibodies	>9 publications with Sgce and Embryonic Tissue
Joint Antibodies	>3 publications with Sgce and Joint
Bone Antibodies	>2 publications with Sgce and Bone
Heart Antibodies	>2 publications with Sgce and Heart
Lung Antibodies	>1 publications with Sgce and Lung
Skin Antibodies	>1 publications with Sgce and Skin
Eye Antibodies	>1 publications with Sgce and Eye
Prostate Antibodies	>1 publications with Sgce and Prostate