Elongation Factor 1-Delta (EF1D) Human Recombinant Protein

This gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit, delta, functions as guanine nucleotide exchange factor. It is reported that following HIV-1 infection, this subunit interacts with HIV-1 Tat. This interaction results in repression of translation of host cell proteins and enhanced translation of viral proteins. Several alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. Related pseudogenes have been defined on chromosomes 1, 6, 7, 9, 11, 13, 17, 19.[provided by RefSeq, Aug 2010]

EEF1D: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP. Belongs to the EF-1-beta/EF-1-delta family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Translation elongation; Translation

Chromosomal Location of Human Ortholog: 8q24.3

Cellular Component: cytoplasm; cytosol; endoplasmic reticulum; eukaryotic translation elongation factor 1 complex; nucleolus; nucleus

Molecular Function: DNA binding; heat shock protein binding; protein binding; signal transducer activity; transcription activator binding; translation elongation factor activity; translation factor activity, nucleic acid binding

Biological Process: cellular protein metabolic process; gene expression; mRNA transcription; positive regulation of I-kappaB kinase/NF-kappaB cascade; regulation of transcription, DNA-dependent; signal transduction; transcription, DNA-dependent; translation; translational elongation