Botulinum Neurotoxin Type F (botF) Clostridium Botulinum Recombinant Protein

Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '58-Gln-|-Lys-59' bond of synaptobrevins-1 and -2.

Sequence of the gene encoding type F neurotoxin of Clostridium botulinum.East A.K., Richardson P.T., Allaway D., Collins M.D., Roberts T.A., Thompson D.E.FEMS Microbiol. Lett. 75:225-230(1992) Conserved structure of genes encoding components of botulinum neurotoxin complex M and the sequence of the gene coding for the nontoxic component in nonproteolytic Clostridium botulinum type F.East A.K., Collins M.D.Curr. Microbiol. 29:69-77(1994) Gene probes for identification of the botulinal neurotoxin gene and specific identification of neurotoxin types B, E, and F.Campbell K.D., Collins M.D., East A.K.J. Clin. Microbiol. 31:2255-2262(1993) Cleavage of members of the synaptobrevin/VAMP family by types D and F botulinal neurotoxins and tetanus toxin.Yamasaki S., Baumeister A., Binz T., Blasi J., Link E., Cornille F., Roques B., Fykse E.M., Suedhof T.C., Jahn R., Niemann H.J. Biol. Chem. 269:12764-12772(1994)

Small volumes of botF recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS1054950 is a recombinant protein targeting botF. Also known as Recombinant Clostridium botulinum Botulinum neurotoxin type F. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.