Allograft Inflammatory Factor 1 (AIF1) Mouse Recombinant Protein

Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation.

Allograft inflammatory factor-1 augments productions of interleukin-6, -10, -12 by a mouse macrophage line.Watano K., Iwabuchi K., Fujii S., Ishimori N., Mitsuhashi S., Ato M., Kitabatake A., Onoe K.Immunology 104:307-316(2001) Structure of the mouse iba1 gene.Imai Y., Ohsawa K., Kohsaka S. Allograft inflammatory factor-1 gene.Hu S.P., Russell M.E. Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.Genome Res. 13:2621-2636(2003) Involvement of Iba1 in membrane ruffling and phagocytosis of macrophages/microglia.Ohsawa K., Imai Y., Kanazawa H., Sasaki Y., Kohsaka S.J. Cell Sci. 113:3073-3084(2000) Iba1 is an actin-cross-linking protein in macrophages/microglia.Sasaki Y., Ohsawa K., Kanazawa H., Kohsaka S., Imai Y.Biochem. Biophys. Res. Commun. 286:292-297(2001) Macrophage/microglia-specific protein Iba1 enhances membrane ruffling and Rac activation via phospholipase C-gamma -dependent pathway.Kanazawa H., Ohsawa K., Sasaki Y., Kohsaka S., Imai Y.J. Biol. Chem. 277:20026-20032(2002) Microglia/macrophage-specific protein Iba1 binds to fimbrin and enhances its actin-bundling activity.Ohsawa K., Imai Y., Sasaki Y., Kohsaka S.J. Neurochem. 88:844-856(2004) X-ray structures of the microglia/macrophage-specific protein Iba1 from human and mouse demonstrate novel molecular conformation change induced by calcium binding.Yamada M., Ohsawa K., Imai Y., Kohsaka S., Kamitori S.J. Mol. Biol. 364:449-457(2006)

Small volumes of Aif1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS1055052 is a recombinant protein targeting Aif1. Also known as Recombinant Mouse Allograft inflammatory factor 1. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.