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Glycine Dehydrogenase [Decarboxylating], Mitochondrial (GLDC) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1058201

MBS1058201 is a recombinant protein targeting GLDC. Also known as Recombinant Human Glycine dehydrogenase [decarboxylating], mitochondrial (GLDC) , partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$860 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Glycine dehydrogenase [decarboxylating], mitochondrial (GLDC), Recombinant Protein
Full Product Name
Recombinant Human Glycine dehydrogenase [decarboxylating], mitochondrial (GLDC) , partial
Product Gene Name
Sequence
ATIRAYLNQK GEGHRTVCLI PKSAHGTNPA SAHMAGMKIQ PVEVDKYGNI DAVHLKAMVD KHKENLAAIM ITYPSTNGVF EENISDVCDL IHQHGGQVYL DGANMNAQVG ICRPGDFGSD VSHLNLHKTF CIPHGGGGPG MGPIGVKKHL APFLPNHPVI SLKRNEDACP VGTVSAAPWG SSSILPISWA YIKMMGGKGL KQATETA
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
112,730 Da
Sequence Positions
627-833aa; Partial
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
238300
3D Structure
ModBase 3D Structure for P23378
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of GLDC recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for GLDC. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
glycine dehydrogenase (decarboxylating), mitochondrial
NCBI Official Synonym Full Names
glycine decarboxylase
NCBI Official Symbol
GLDC
NCBI Official Synonym Symbols
GCE; GCSP; HYGN1
UniProt Protein Name
Glycine dehydrogenase (decarboxylating), mitochondrial
UniProt Synonym Protein Names
Glycine cleavage system P protein; Glycine decarboxylase
UniProt Gene Name
GLDC
NCBI Protein Information
glycine dehydrogenase (decarboxylating), mitochondrial

NCBI Summary for GLDC

Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the P protein, which binds to glycine and enables the methylamine group from glycine to be transferred to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH).[provided by RefSeq, Jan 2010]
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UniProt Comments for GLDC

The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GCSH).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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