Human F2RL2 Recombinant Protein – Cat# MBS1059302

Proteinase-Activated Receptor 3 (F2RL2)-Vlps (F2RL2) Human Recombinant Protein

Name: F2RL2 Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1059302
Price: 2090 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1059302

MBS1059302 is a recombinant protein targeting F2RL2. Also known as Recombinant Human Proteinase-activated receptor 3 (F2RL2)-VLPs. Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$2090 / 0.02 mg (Mammalian-Cell) +2 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Proteinase-activated receptor 3 (F2RL2)-VLPs, Recombinant Protein

Full Product Name

Recombinant Human Proteinase-activated receptor 3 (F2RL2)-VLPs

Product Gene Name

F2RL2 recombinant protein

Product Synonym Gene Name

F2RL2; PAR3

Product Synonym Names

Recombinant Proteinase-activated receptor 3 (F2RL2); Proteinase-activated receptor 3; PAR-3; Coagulation factor II receptor-like 2 Thrombin receptor-like 2

Sequence

TFRGAPPNSF EEFPFSALEG WTGATITVKI KCPEESASHL HVKNATMGYL TSSLSTKLIP AIYLLVFVVG VPANAVTLWM LFFRTRSICT TVFYTNLAIA DFLFCVTLPF KIAYHLNGNN WVFGEVLCRA TTVIFYGNMY CSILLLACIS INRYLAIVHP FTYRGLPKHT YALVTCGLVW ATVFLYMLPF FILKQEYYLV QPDITTCHDV HNTCESSSPF QLYYFISLAF FGFLIPFVLI IYCYAAIIRT LNAYDHRWLW YVKASLLILV IFTICFAPSN IILIIHHANY YYNNTDGLYF IYLIALCLGS LNSCLDPFLY FLMSKTRNHS TAYLTK

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

Molecular Weight

42,508 Da

Sequence Positions

39-374aa; Full Length of Mature Protein

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

Chromosome Location

Chromosome: 5; NC_000005.9 (75911307..75919259, complement). Location: 5q13

OMIM

601919

3D Structure

ModBase 3D Structure for O00254

Species

Homo sapiens (Human)

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of F2RL2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for F2RL2. It may not necessarily be applicable to this product.

NCBI GI #

4758326

NCBI GeneID

2151

NCBI Accession #

NP_004092.1

UniProt Primary Accession #

O00254

UniProt Secondary Accession #

Q52M68; Q7Z3W3; B2R754

UniProt Related Accession #

O00254

GenBank Nucleotide #

NM_004101.3

NCBI Official Full Name

proteinase-activated receptor 3 isoform 1

NCBI Official Synonym Full Names

coagulation factor II (thrombin) receptor-like 2

NCBI Official Symbol

F2RL2

NCBI Official Synonym Symbols

PAR3; PAR-3

UniProt Protein Name

Proteinase-activated receptor 3

UniProt Synonym Protein Names

Coagulation factor II receptor-like 2; Thrombin receptor-like 2

Protein Family

Proteinase-activated receptor

UniProt Gene Name

F2RL2

UniProt Synonym Gene Names

PAR3; PAR-3

UniProt Entry Name

PAR3_HUMAN

NCBI Protein Information

proteinase-activated receptor 3; thrombin receptor-like 2; protease-activated receptor 3; proteinase-activated receptor-3; Coagulation factor II receptor-like 2 (protease-actovated receptor 3)

NCBI Summary for F2RL2

This gene encodes a member of the protease-activated receptor (PAR) family which is a subfamily of the seven transmembrane G protein-coupled cell surface receptor family. The encoded protein acts as a cofactor in the thrombin-mediated cleavage and activation of the protease-activated receptor family member PAR4. The encoded protein plays an essential role in hemostasis and thrombosis. Alternate splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Feb 2012]

UniProt Comments for F2RL2

PAR3: a G-protein coupled receptor for activated thrombin or trypsin. Coupled to G proteins that stimulate phosphoinositide hydrolysis. Interacts with INSC/inscuteable and probably GPSM2. Highest expression in the megakaryocytes of the bone marrow, lower in mature megakaryocytes, in platelets and in a variety of other tissues such as heart and gut.

Protein type: Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1

Chromosomal Location of Human Ortholog: 5q13

Cellular Component: integral to plasma membrane; apical plasma membrane; plasma membrane; extracellular region

Molecular Function: protein binding; phosphoinositide phospholipase C activity; thrombin receptor activity

Biological Process: platelet activation; metabolic process; response to wounding; blood coagulation

Research Articles on F2RL2

1. Human PAR-3 is regulated post-transcriptionally via the mRNA-stabilizing factor HuR, whereas transcriptional control involves nuclear factor of activated T cells (NFAT).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with F2RL2 recombinant protein

Reference Product	PubMed Publications
F2RL3 recombinant protein	>1 publications with F2RL2 and F2RL3

Pathways associated with F2RL2 recombinant protein

Products by Pathway	Pathway Diagram
CDC42 Signaling Events Pathway antibodies	CDC42 Signaling Events Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
ErbB1 Downstream Signaling Pathway antibodies	ErbB1 Downstream Signaling Pathway Diagram
G Alpha (q) Signalling Events Pathway antibodies	G Alpha (q) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
GPCRs, Class A Rhodopsin-like Pathway antibodies	GPCRs, Class A Rhodopsin-like Pathway Diagram
Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies	Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
Hemostasis Pathway antibodies	Hemostasis Pathway Diagram
Insulin Pathway antibodies	Insulin Pathway Diagram

Diseases associated with F2RL2 recombinant protein

Disease Name	Pubmed Publications
Drug Toxicity Antibodies	>1 publications with F2RL2 and Drug Toxicity
Inflammation Antibodies	>1 publications with F2RL2 and Inflammation

Organs/Tissues associated with F2RL2 recombinant protein

Organ/Tissue Name	Pubmed Publications
Vascular Antibodies	>1 publications with F2RL2 and Vascular
Muscle Antibodies	>1 publications with F2RL2 and Muscle