Mouse AVPR2 Recombinant Protein – Cat# MBS1059472

Vasopressin V2 Receptor (AVPR2) Mouse Recombinant Protein

Name: AVPR2 Recombinant Protein; Vasopressin V2 Receptor; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS1059472
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1059472

MBS1059472 is a recombinant protein targeting Avpr2. Also known as Recombinant Mouse Vasopressin V2 receptor (Avpr2). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

Please Inquire

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Vasopressin V2 receptor (Avpr2), Recombinant Protein

Full Product Name

Recombinant Mouse Vasopressin V2 receptor (Avpr2)

Product Gene Name

Avpr2 recombinant protein

Product Synonym Gene Name

Avpr2; V2r

Product Synonym Names

Recombinant Vasopressin V2 receptor (Avpr2); Vasopressin V2 receptor; V2R; AVPR V2 Antidiuretic hormone receptor Renal-type arginine vasopressin receptor

Sequence

MILVSTTSAV PGALSSPSSP SNSSQEELLD DRDPLLVRAE LALLSTIFVA VALSNGLVLG ALIRRGRRGR WAPMHVFISH LCLADLAVAL FQVLPQLAWD ATDRFHGPDA LCRAVKYLQM VGMYASSYMI LAMTLDRHRA ICRPMLAYRH GGGARWNRPV LVAWAFSLLL SLPQLFIFAQ RDVGNGSGVF DCWARFAEPW GLRAYVTWIA LMVFVAPALG IAACQVLIFR EIHASLVPGP SERAGRRRRG HRTGSPSEGA HVSAAMAKTV RMTLVIVIVY VLCWAPFFLV QLWAAWDPEA PLERPPFVLL MLLASLNSCT NPWIYASFSS SVSSELRSLL CCAQRHTTHS LGPQDESCAT ASSSLMKDTP S

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

Molecular Weight

40,645 Da

Sequence Positions

1-371

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

Chromosome Location

Chromosome: X; NC_000086.7 (73892102..73894427). Location: X A7.3; X 37.46 cM

3D Structure

ModBase 3D Structure for O88721

Species

Mus musculus (Mouse)

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Avpr2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Avpr2. It may not necessarily be applicable to this product.

NCBI GI #

9506413

NCBI GeneID

12000

NCBI Accession #

NP_062277.1

UniProt Primary Accession #

O88721

UniProt Related Accession #

O88721

GenBank Nucleotide #

NM_019404.1

NCBI Official Full Name

vasopressin V2 receptor

NCBI Official Synonym Full Names

arginine vasopressin receptor 2

NCBI Official Symbol

Avpr2

NCBI Official Synonym Symbols

DI1; DIR; ND1; V2R; ADHR

UniProt Protein Name

Vasopressin V2 receptor

UniProt Synonym Protein Names

AVPR V2; Antidiuretic hormone receptor; Renal-type arginine vasopressin receptor

Protein Family

Vasopressin V2 receptor

UniProt Gene Name

Avpr2

UniProt Synonym Gene Names

V2r; V2R

UniProt Entry Name

V2R_MOUSE

NCBI Protein Information

vasopressin V2 receptor; AVPR V2; antidiuretic hormone receptor; nephrogenic diabetes insipidus; renal-type arginine vasopressin receptor

NCBI Summary for Avpr2

This gene encodes a member of the G-protein coupled receptor 1 family and the vasopressin/oxytocin receptor subfamily. The encoded protein is an arginine vasopressin receptor which, when stimulated, activates the Gs protein/adenylyl cyclase signaling cascade and is involved in water and electrolyte homeostasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

UniProt Comments for Avpr2

AVPR2: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption. Defects in AVPR2 are the cause of nephrogenic syndrome of inappropriate antidiuresis (NSIAD). This disorder is characterized by an inability to excrete a free water load, with inappropriately concentrated urine and resultant hyponatremia, hypoosmolarity, and natriuresis. Defects in AVPR2 are the cause of diabetes insipidus nephrogenic X-linked (XNDI); also known as diabetes insipidus nephrogenic type 1. XNDI is caused by the inability of the renal collecting ducts to absorb water in response to arginine vasopressin. It is characterized by excessive water drinking (polydypsia), excessive urine excretion (polyuria), persistent hypotonic urine, and hypokalemia. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GPCR, family 1; Transporter; Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass; Transporter, aquaporin family

Cellular Component: membrane; integral to plasma membrane; plasma membrane; integral to membrane; intracellular

Molecular Function: G-protein coupled receptor activity; signal transducer activity; peptide binding; vasopressin receptor activity

Biological Process: I-kappaB kinase/NF-kappaB cascade; G-protein coupled receptor protein signaling pathway; regulation of systemic arterial blood pressure by vasopressin; response to cytokine stimulus; positive regulation of cell proliferation; positive regulation of vasoconstriction; interferon-gamma production; positive regulation of systemic arterial blood pressure; signal transduction; positive regulation of blood pressure; cellular response to hormone stimulus

Research Articles on Avpr2

1. In polycystic kidney disease, structural or functional loss of cilia leads to abnormal trafficking of AQP2/V2R leading to enhanced salt and water absorption.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Avpr2 recombinant protein

Products by Pathway	Pathway Diagram
Aquaporin-mediated Transport Pathway antibodies	Aquaporin-mediated Transport Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
G Alpha (s) Signalling Events Pathway antibodies	G Alpha (s) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
GPCRs, Class A Rhodopsin-like Pathway antibodies	GPCRs, Class A Rhodopsin-like Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram
Non-odorant GPCRs Pathway antibodies	Non-odorant GPCRs Pathway Diagram
Peptide GPCRs Pathway antibodies	Peptide GPCRs Pathway Diagram

Diseases associated with Avpr2 recombinant protein

Disease Name	Pubmed Publications
Diabetes Insipidus, Nephrogenic Antibodies	>89 publications with Avpr2 and Diabetes Insipidus, Nephrogenic
Kidney Diseases Antibodies	>84 publications with Avpr2 and Kidney Diseases
Polyuria Antibodies	>22 publications with Avpr2 and Polyuria
Genetic Diseases, X-Linked Antibodies	>12 publications with Avpr2 and Genetic Diseases, X-Linked
Brain Diseases Antibodies	>11 publications with Avpr2 and Brain Diseases
Hyponatremia Antibodies	>10 publications with Avpr2 and Hyponatremia
Inappropriate ADH Syndrome Antibodies	>10 publications with Avpr2 and Inappropriate ADH Syndrome
Nephrogenic Syndrome of Inappropriate Antidiuresis Antibodies	>9 publications with Avpr2 and Nephrogenic Syndrome of Inappropriate Antidiuresis
Disease Models, Animal Antibodies	>3 publications with Avpr2 and Disease Models, Animal
Hypertension Antibodies	>2 publications with Avpr2 and Hypertension

Organs/Tissues associated with Avpr2 recombinant protein

Organ/Tissue Name	Pubmed Publications
Kidney Antibodies	>28 publications with Avpr2 and Kidney
Brain Antibodies	>4 publications with Avpr2 and Brain