Respiratory Syncytial Virus A Major Surface Glycoprotein G (G) Human Recombinant Protein

Attaches the virion to the host cell membrane by interacting with heparan sulfate, initiating the infection. Interacts with host CX3CR1, the receptor for the CX3C chokine fractalkine, to modulate the immune response and facilitate infection. Unlike the other paramyxovirus attachment proteins, lacks both neuraminidase and hagglutinating activities. Secreted glycoprotein G helps RSV escape antibody-dependent restriction of replication by acting as an antigen decoy and by modulating the activity of leukocytes bearing Fcgamma receptors.

Nucleotide sequence of the G protein gene of human respiratory syncytial virus reveals an unusual type of viral membrane protein.Wertz G.W., Collins P.L., Huang Y., Gruber C., Levine S., Ball L.A.Proc. Natl. Acad. Sci. U.S.A. 82:4075-4079(1985) A cold-passaged, attenuated strain of human respiratory syncytial virus contains mutations in the F and L genes.Connors M., Crowe J.E. Jr., Firestone C.Y., Murphy B.R., Collins P.L.Virology 208:478-484(1995) The membrane-associated and secreted forms of the respiratory syncytial virus attachment glycoprotein G are synthesized from alternative initiation codons.Roberts S.R., Lichtenstein D., Ball L.A., Wertz G.W.J. Virol. 68:4538-4546(1994) Identification of a linear heparin binding domain for human respiratory syncytial virus attachment glycoprotein G.Feldman S.A., Hendry R.M., Beeler J.A.J. Virol. 73:6610-6617(1999) The fusion glycoprotein of human respiratory syncytial virus facilitates virus attachment and infectivity via an interaction with cellular heparan sulfate.Feldman S.A., Audet S., Beeler J.A.J. Virol. 74:6442-6447(2000) CX3C chemokine mimicry by respiratory syncytial virus G glycoprotein.Tripp R.A., Jones L.P., Haynes L.M., Zheng H., Murphy P.M., Anderson L.J.Nat. Immunol. 2:732-738(2001) The respiratory syncytial virus small hydrophobic protein is phosphorylated via a mitogen-activated protein kinase p38-dependent tyrosine kinase activity during virus infection.Rixon H.W., Brown G., Murray J.T., Sugrue R.J.J. Gen. Virol. 86:375-384(2005) Interaction between the respiratory syncytial virus G glycoprotein cytoplasmic domain and the matrix protein.Ghildyal R., Li D., Peroulis I., Shields B., Bardin P.G., Teng M.N., Collins P.L., Meanger J., Mills J.J. Gen. Virol. 86:1879-1884(2005) The RSV F and G glycoproteins interact to form a complex on the surface of infected cells.Low K.W., Tan T., Ng K., Tan B.H., Sugrue R.J.Biochem. Biophys. Res. Commun. 366:308-313(2008) The secreted form of respiratory syncytial virus G glycoprotein helps the virus evade antibody-mediated restriction of replication by acting as an antigen decoy and through effects on fc receptor-bearing leukocytes.Bukreyev A., Yang L., Fricke J., Cheng L., Ward J.M., Murphy B.R., Collins P.L.J. Virol. 82:12191-12204(2008)

Small volumes of G recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS1059692 is a recombinant protein targeting G. Also known as Recombinant Human respiratory syncytial virus A Major surface glycoprotein G (G), partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.