Drosophila Melanogaster dco Recombinant Protein – Cat# MBS1064473

Discs Overgrown Protein Kinase (dco) Drosophila Melanogaster Recombinant Protein

Name: dco Recombinant Protein; Drosophila Melanogaster; MyBioSource
Brand: MyBioSource
SKU: MBS1064473
Price: 1210 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1064473

MBS1064473 is a recombinant protein targeting dco. Also known as Recombinant Drosophila melanogaster Discs overgrown protein kinase (dco). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$1210 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Discs overgrown protein kinase (dco), Recombinant Protein

Full Product Name

Recombinant Drosophila melanogaster Discs overgrown protein kinase (dco)

Product Gene Name

dco recombinant protein

Sequence

MELRVGNKYR LGRKIGSGSF GDIYLGTTIN TGEEVAIKLE CIRTKHPQLH IESKFYKTMQ GGIGIPRIIW CGSEGDYNVM VMELLGPSLE DLFNFCSRRF SLKTVLLLAD QMISRIDYIH SRDFIHRDIK PDNFLMGLGK KGNLVYIIDF GLAKKFRDAR SLKHIPYREN KNLTGTARYA SINTHLGIEQ SRRDDLESLG YVLMYFNLGA LPWQGLKAAN KRQKYERISE KKLSTSIVVL CKGFPSEFVN YLNFCRQMHF DQRPDYCHLR KLFRNLFHRL GFTYDYVFDW NLLKFGGPRN PQAIQQAQDG ADGQAGHDAV AAAAAVAAAA AASSHQQQQH KVNAALGGGG GSAAQQQLQG GQTLAMLGGN GGGNGSQLIG GNGLNMDDSM AATNSSRPPY DTPERRPSIR MRQGGGGGGG GVGVGGMPSG GGGGGVGNAK

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

47,958 Da

Sequence Positions

1-440, Full length protein

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

3D Structure

ModBase 3D Structure for O76324

Species

Drosophila melanogaster (Fruit fly)

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of dco recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for dco. It may not necessarily be applicable to this product.

NCBI GI #

442622013

NCBI GeneID

43673

NCBI Accession #

NP_001263132.1

UniProt Primary Accession #

O76324

UniProt Secondary Accession #

Q0KHY4; Q9V462; A4V3P5

UniProt Related Accession #

O76324

GenBank Nucleotide #

NM_001276203.1

NCBI Official Full Name

discs overgrown, isoform D

NCBI Official Synonym Full Names

discs overgrown

NCBI Official Symbol

dco

NCBI Official Synonym Symbols

0538/13; 0915/10; 1396/02; 1447/01; 1460/09; CG2048; CK1delta/epsilon; ck1epsilon; CK1epsilon; CKIepsilon; dbt; Dbt; DBT; DBT/CK1epsilon; dCKIepsilon; Dco; DCO; dco-1; Dco/CK1; DCO/CKIe; ddbt; DmelCG2048; l(3)dco; l(3)dco-1; l(3)discs overgrown; l(3)discs

UniProt Protein Name

Discs overgrown protein kinase

UniProt Synonym Protein Names

Protein double-time

Protein Family

Discs overgrown protein kinase

UniProt Gene Name

dco

UniProt Synonym Gene Names

dbt

NCBI Protein Information

CG2048 gene product from transcript CG2048-RD

UniProt Comments for dco

Involved in circadian rhythms, viability and molecular oscillations of the clock genes period (per) and timeless (tim). Dbt reduces the stability and thus the accumulation of monomeric per proteins, probably through phosphorylation. No evident circadian oscillation is detected in head. Together with CkIalpha, regulates processing of ci by phosphorylating it which promotes its binding to slmb, the F-box recognition component of the SCF(slmb) E3 ubiquitin-protein ligase (PubMed:16326393).

Research Articles on dco

1. results demonstrate that Bride of Doubletime (BDBT) interacts with doubletime(DBT)in a manner requiring the DBT nuclear localization signal for nuclear localization and that the interaction is required to produce a fully functional circadian complex

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with dco recombinant protein

Products by Pathway	Pathway Diagram
Circadian Clock Pathway antibodies	Circadian Clock Pathway Diagram
Circadian Rhythm - Fly Pathway antibodies	Circadian Rhythm - Fly Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
FoxO Signaling Pathway antibodies	FoxO Signaling Pathway Diagram
Hedgehog Signaling Pathway antibodies	Hedgehog Signaling Pathway Diagram
Hedgehog Signaling Pathway antibodies	Hedgehog Signaling Pathway Diagram
Hippo Signaling Pathway - Fly antibodies	Hippo Signaling Pathway - Fly Diagram
Hippo Signaling Pathway - Fly antibodies	Hippo Signaling Pathway - Fly Diagram
RNF Mutants Show Enhanced WNT Signaling And Proliferation Pathway antibodies	RNF Mutants Show Enhanced WNT Signaling And Proliferation Pathway Diagram
Signal Transduction Pathway antibodies	Signal Transduction Pathway Diagram

Organs/Tissues associated with dco recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>80 publications with dco and Blood
Ovary Antibodies	>6 publications with dco and Ovary
Embryonic Tissue Antibodies	>3 publications with dco and Embryonic Tissue
Gonad Antibodies	>2 publications with dco and Gonad
Whole Body Antibodies	>2 publications with dco and Whole Body