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Tyrosine-Protein Phosphatase Non-Receptor Type Substrate 1 (SIRPA) Bovine Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1065849

MBS1065849 is a recombinant protein targeting SIRPA. Also known as Recombinant Bovine Tyrosine-protein phosphatase non-receptor type substrate 1 (SIRPA). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Tyrosine-protein phosphatase non-receptor type substrate 1 (SIRPA), Recombinant Protein
Full Product Name
Recombinant Bovine Tyrosine-protein phosphatase non-receptor type substrate 1 (SIRPA)
Product Gene Name
Product Synonym Gene Name
SIRPA; MYD1; PTPNS1; SHPS1; SIRP
Product Synonym Names
Tyrosine-protein phosphatase non-receptor type substrate 1; SHP substrate 1; SHPS-1; CD172 antigen-like family member A; Inhibitory receptor SHPS-1; MyD-1 antigen; Signal-regulatory protein alpha-1; Sirp-alpha-1; CD_antigen=; CD172a
Sequence
G DGELQVIQPE RSVSVAAGET ATLHCTVTSL SPVGPIKWFK GTGPGREFIY SQKEAPFPRV TNVSDATKRN NMDFSIRISN ITPADAGVYY CVKFRKEERG DMEFKSGPGT HLTVSAKPSP PVLSGPTVRA TPEQTVNFTC TSHGFSPRNI SLKWFKNGNE LSASQTSVDP EDNNVSYSIN STTKVLLATG DVHSQVICEV AHVTLQGGPP LRGTANLSET IRVPPTLEIT GSPSAGNQVN VTCQVNKFYP RHLQLTWLEN GNMSRTEAAS VFVENKDGTF NQTSWFLVNS SAHREAVVLT CQVEHDGQPA VSKNHTLEVS APQKDQDTGQ TPGPNDSNWT S
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
55,093 Da
Sequence Positions
30-371
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for O46631
Species
Bos taurus (Bovine)
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of SIRPA recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SIRPA. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
tyrosine-protein phosphatase non-receptor type substrate 1
NCBI Official Synonym Full Names
signal-regulatory protein alpha<
NCBI Official Symbol
SIRPA
NCBI Official Synonym Symbols
MYD-1; PTPNS1
UniProt Protein Name
Tyrosine-protein phosphatase non-receptor type substrate 1
UniProt Synonym Protein Names
CD172 antigen-like family member A; Inhibitory receptor SHPS-1; MyD-1 antigen; Signal-regulatory protein alpha-1; Sirp-alpha-1; CD_antigen: CD172a
UniProt Gene Name
SIRPA
UniProt Synonym Gene Names
MYD1; PTPNS1; SHPS1; SIRP; SHP substrate 1; SHPS-1; Sirp-alpha-1
UniProt Entry Name
SHPS1_BOVIN
NCBI Protein Information
tyrosine-protein phosphatase non-receptor type substrate 1; SHPS-1; sirp-alpha-1; MyD-1 antigen; SHP substrate 1; inhibitory receptor SHPS-1; signal-regulatory protein alpha-1; CD172 antigen-like family member A; protein tyrosine phosphatase, non-receptor type substrate 1

UniProt Comments for SIRPA

Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells ().
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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