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Werner Syndrome ATP-Dependent Helicase Homolog (WRN) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1066596

This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein… More details

$1310 / 0.5 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Werner syndrome ATP-dependent helicase homolog (Wrn), Recombinant Protein
Full Product Name
Recombinant Mouse Werner syndrome ATP-dependent helicase homolog (Wrn) , partial
Product Gene Name
Wrn recombinant protein
Sequence
DLKPFLVRKA SSAWEFEGPT IIYCPSRKMT EQVTAELGKL NLACRTYHAG MKISERKDVH HRFLRDEIQC VVATVAFGMG INKADIRKVI HYGAPKEMES YYQEIGRAGR DGLQSSCHLL WAPADFNTSR NLLIEIHDEK FRLYKLKMMV KMEK
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
157,204 Da
Sequence Positions
713-866; Helicase C-terminal domain
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for O09053
Species
Mouse
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Wrn recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Wrn purchase

MBS1066596 is a recombinant protein targeting Wrn. Also known as Recombinant Mouse Werner syndrome ATP-dependent helicase homolog (Wrn) , partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Wrn. It may not necessarily be applicable to this product.

NCBI GI #
170763504
NCBI GeneID
22427
NCBI Accession #
NP_001116294.1
UniProt Primary Accession #
O09053
UniProt Secondary Accession #
O09050; Q80YP9; Q9JKD4; Q9Z241; Q9Z242
UniProt Related Accession #
O09053
GenBank Nucleotide #
NM_001122822.1
NCBI Official Full Name
Werner syndrome ATP-dependent helicase homolog
NCBI Official Synonym Full Names
Werner syndrome RecQ like helicase
NCBI Official Symbol
Wrn
NCBI Official Synonym Symbols
AI846146
UniProt Protein Name
Werner syndrome ATP-dependent helicase homolog
UniProt Synonym Protein Names
Exonuclease WRN (EC:3.1.-.-)
Protein Family
Werner syndrome ATP-dependent helicase
UniProt Gene Name
Wrn
NCBI Protein Information
Werner syndrome ATP-dependent helicase homolog

UniProt Comments for Wrn

Multifunctional enzyme that has both magnesium and ATP-dependent DNA-helicase activity and 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang. Has no nuclease activity towards single-stranded DNA or blunt-ended double-stranded DNA. Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Important for genomic integrity. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A (). Plays a role in double-strand break repair after gamma-irradiation ().
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Research Articles on Wrn

1. A mislocalization of the Wrn mutant protein in the liver endoplasmic reticulum fraction increased oxidative stress in that cellular compartment. Vitamin C reversed this oxidative stress.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Wrn recombinant protein

 Reference Product  PubMed Publications
 Wrnip1 recombinant protein  >9 publications with Wrn and Wrnip1

Diseases associated with Wrn recombinant protein

 Disease Name  Pubmed Publications
 Werner Syndrome Antibodies  >539 publications with Wrn and Werner Syndrome
 Aging, Premature Antibodies  >247 publications with Wrn and Aging, Premature
 Neoplasms Antibodies  >132 publications with Wrn and Neoplasms
 Chromosome Aberrations Antibodies  >39 publications with Wrn and Chromosome Aberrations
 Ataxia Antibodies  >29 publications with Wrn and Ataxia
 Carcinoma Antibodies  >27 publications with Wrn and Carcinoma
 Nervous System Diseases Antibodies  >23 publications with Wrn and Nervous System Diseases
 Gastrointestinal Diseases Antibodies  >21 publications with Wrn and Gastrointestinal Diseases
 Intestinal Neoplasms Antibodies  >17 publications with Wrn and Intestinal Neoplasms
 Adenocarcinoma Antibodies  >17 publications with Wrn and Adenocarcinoma

Organs/Tissues associated with Wrn recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >34 publications with Wrn and Skin
 Brain Antibodies  >14 publications with Wrn and Brain
 Lung Antibodies  >12 publications with Wrn and Lung
 Liver Antibodies  >10 publications with Wrn and Liver
 Embryonic Tissue Antibodies  >8 publications with Wrn and Embryonic Tissue
 Testis Antibodies  >6 publications with Wrn and Testis
 Bone Marrow Antibodies  >3 publications with Wrn and Bone Marrow
 Eye Antibodies  >3 publications with Wrn and Eye
 Spleen Antibodies  >2 publications with Wrn and Spleen
 Prostate Antibodies  >2 publications with Wrn and Prostate
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