Human ZWINT Recombinant Protein – Cat# MBS1066845

ZW10 Interactor (ZWINT) Human Recombinant Protein

Name: ZWINT Recombinant Protein; ZW10 Interactor; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1066845
Price: 455 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1066845

Part of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity. Required to target ZW10 to the kinetochore at prometaphase. More details

$455 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ZW10 interactor (ZWINT), Recombinant Protein

Full Product Name

Recombinant Human ZW10 interactor (ZWINT)

Product Gene Name

ZWINT recombinant protein

Product Synonym Names

ZW10 interactor; ZW10-interacting protein 1; Zwint-1

Sequence

MEAAETEAEA AALEVLAEVA GILEPVGLQE EAELPAKILV EFVVDSQKKD KLLCSQLQVA DFLQNILAQE DTAKGLDPLA SEDTSRQKAI AAKEQWKELK ATYREHVEAI KIGLTKALTQ MEEAQRKRTQ LREAFEQLQA KKQMAMEKRR AVQNQWQLQQ EKHLQHLAEV SAEVRERKTG TQQELDGVFQ KLGNLKQQAE QERDKLQRYQ TFLQLLYTLQ GKLLFPEAEA EAENLPDDKP QQPTRPQEQS TGDTMGRDPG VSFKAVGLQP AGDVNLP

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

58.2 kDa

Sequence Positions

1-277aa; Full Length of BC020979

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

609177

3D Structure

ModBase 3D Structure for O95229

Species

Homo sapiens (Human)

Production Note

Special Offer: The E Coli host-expressed protein is manufactured from a stock plasmid containing the protein gene. E Colihost-expressed protein is stocked in different unit sizes ranging from as small as 10 ug to as large as 1 mg. Bulk inventory is also available. The E Coli host-expressed protein has been ordered over and over again by researchers and has stood the test of time as both a robust protein and important target for the research community. It is part of our new program to make our most popular protein targets and corresponding hosts available in expanded unit sizes and with a quick processing time. Select E Coli host-expressed protein for the fastest delivery among all hosts. Please contact our technical support team or email to support@mybiosource.com for more details.

Product Categories/Family for ZWINT recombinant protein

Cell Biology

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of ZWINT recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ZWINT purchase

MBS1066845 is a recombinant protein targeting ZWINT. Also known as Recombinant Human ZW10 interactor (ZWINT). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for ZWINT. It may not necessarily be applicable to this product.

NCBI GI #

53729320

NCBI GeneID

11130

NCBI Accession #

NP_001005413.1

UniProt Primary Accession #

O95229

UniProt Secondary Accession #

Q0D2I3; Q9BWD0; A6NNV6

UniProt Related Accession #

O95229

GenBank Nucleotide #

NM_001005413.1

NCBI Official Full Name

ZW10 interactor isoform b

NCBI Official Synonym Full Names

ZW10 interacting kinetochore protein

NCBI Official Symbol

ZWINT

NCBI Official Synonym Symbols

ZWINT1; KNTC2AP; HZwint-1

UniProt Protein Name

ZW10 interactor

UniProt Synonym Protein Names

ZW10-interacting protein 1; Zwint-1

Protein Family

ZW10 interactor

UniProt Gene Name

ZWINT

UniProt Synonym Gene Names

Zwint-1

UniProt Entry Name

ZWINT_HUMAN

NCBI Protein Information

ZW10 interactor; zwint-1; human ZW10 interacting protein-1; ZW10 interactor, kinetochore protein

NCBI Summary for ZWINT

This gene encodes a protein that is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochores. The encoded protein localizes to prophase kinetochores before ZW10 does and it remains detectable on the kinetochore until late anaphase. It has a uniform distribution in the cytoplasm of interphase cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

UniProt Comments for ZWINT

ZWINT: Part of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity. Required to target ZW10 to the kinetochore at prometaphase.

Protein type: Cell cycle regulation

Chromosomal Location of Human Ortholog: 10q21-q22

Cellular Component: kinetochore; cytoplasm; dendrite; nucleus; cytosol

Molecular Function: protein binding; protein N-terminus binding

Biological Process: mitotic sister chromatid segregation; cell division; mitotic cell cycle checkpoint; mitotic cell cycle; establishment of cellular localization

Research Articles on ZWINT

1. the E3 ubiquitin ligase terf causes protein degradation of ZWINT and negatively regulates cell proliferation

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with ZWINT recombinant protein

Reference Product	PubMed Publications
ZW10 recombinant protein	>14 publications with ZWINT and ZW10
NDC80 recombinant protein	>8 publications with ZWINT and NDC80
MIS12 recombinant protein	>7 publications with ZWINT and MIS12
CASC5 recombinant protein	>3 publications with ZWINT and CASC5
SPC25 recombinant protein	>1 publications with ZWINT and SPC25

Pathways associated with ZWINT recombinant protein

Products by Pathway	Pathway Diagram
Cell Cycle Pathway antibodies	Cell Cycle Pathway Diagram
Cell Cycle, Mitotic Pathway antibodies	Cell Cycle, Mitotic Pathway Diagram
M Phase Pathway antibodies	M Phase Pathway Diagram
Mitotic Anaphase Pathway antibodies	Mitotic Anaphase Pathway Diagram
Mitotic Metaphase And Anaphase Pathway antibodies	Mitotic Metaphase And Anaphase Pathway Diagram
Mitotic Prometaphase Pathway antibodies	Mitotic Prometaphase Pathway Diagram
Resolution Of Sister Chromatid Cohesion Pathway antibodies	Resolution Of Sister Chromatid Cohesion Pathway Diagram
Separation Of Sister Chromatids Pathway antibodies	Separation Of Sister Chromatids Pathway Diagram

Diseases associated with ZWINT recombinant protein

Disease Name	Pubmed Publications
Neoplasms Antibodies	>6 publications with ZWINT and Neoplasms
Carcinoma Antibodies	>2 publications with ZWINT and Carcinoma
Congenital Abnormalities Antibodies	>2 publications with ZWINT and Congenital Abnormalities
Breast Neoplasms Antibodies	>2 publications with ZWINT and Breast Neoplasms
Lung Neoplasms Antibodies	>1 publications with ZWINT and Lung Neoplasms
Prostatic Diseases Antibodies	>1 publications with ZWINT and Prostatic Diseases
Urinary Bladder Neoplasms Antibodies	>1 publications with ZWINT and Urinary Bladder Neoplasms
Cell Transformation, Neoplastic Antibodies	>1 publications with ZWINT and Cell Transformation, Neoplastic
Abnormalities, Drug-Induced Antibodies	>1 publications with ZWINT and Abnormalities, Drug-Induced
Fibrosis Antibodies	>1 publications with ZWINT and Fibrosis

Organs/Tissues associated with ZWINT recombinant protein

Organ/Tissue Name	Pubmed Publications
Nerve Antibodies	>9 publications with ZWINT and Nerve
Brain Antibodies	>5 publications with ZWINT and Brain
Lymph Antibodies	>2 publications with ZWINT and Lymph
Testis Antibodies	>2 publications with ZWINT and Testis
Lymph Node Antibodies	>2 publications with ZWINT and Lymph Node
Lung Antibodies	>1 publications with ZWINT and Lung
Kidney Antibodies	>1 publications with ZWINT and Kidney
Bladder Antibodies	>1 publications with ZWINT and Bladder
Bone Antibodies	>1 publications with ZWINT and Bone
Prostate Antibodies	>1 publications with ZWINT and Prostate