Mouse CBFA2T3 Recombinant Protein – Cat# MBS1070785

Protein CBFA2T3 (CBFA2T3) Mouse Recombinant Protein

Name: CBFA2T3 Recombinant Protein; Protein CBFA2T3; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS1070785
Price: 1430 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1070785

The t(16;21)(q24;q22) translocation is a rare but recurrent chromosomal abnormality associated with therapy-related myeloid malignancies. The translocation produces a chimeric gene made up of the 5 -region of the AML1 gene fused to the 3 -region of this gene.… More details

$1430 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Protein CBFA2T3 (Cbfa2t3), Recombinant Protein

Full Product Name

Recombinant Mouse Protein CBFA2T3 (Cbfa2t3)

Product Gene Name

Cbfa2t3 recombinant protein

Sequence

MSQASTTTLE SGALLSGPRG LQYGSPAHRK EKAAAMPDSP AEVKTQPRST PPSMPPPPPT SSQGATRPPS FTPHTHGEDG PATSLPHGRF HGCLKWSMVC LLMNGSSHSP TAIHGAPSTP NGFSNGPATS STASLSTQHL PPACGARQLS KLKRFLTTLQ QFGSDISPEI GERVRTLVLG LVNSTLTIEE FHAKLQEATN FPLRPFVIPF LKANLPLLQR ELLHCARLAK QTPAQYLAQH EQLLLDASAT SPVDSSELLL EVNENGKRRT PDRTKENGSD RDPLHPDHLS KRSCTLSPAQ RCSPSNGLPH PTPPPPPHYR LEDMAMAHHF RDSYRHPDPR ELRERHRPLA IPGSRQEEVI DHRLTEREWA EEWKHLNSLL NCIMDMVEKT RRSLTVLRRC QEADREELNH WIRCYSDSEE GKKGPTPISA RSLNSCSGPE GSQLDVHRDF TPRTLSGYMP EEIWRKAEEA VNEVKRQAMS ELQKAVSDAE RKAHELITTE RAKMERALAE AKRQASEDAL TVINQQEDSS ESCWNCGRKA SETCSGCNAA RYCGSFCQHK DWEKHHHVCG QSLQGPAAAV ADPLPGQPDA TASPSEAGSA GPSRPCSPGP PGPLDAAVPR

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

61,659 Da

Sequence Positions

1-620, Full length protein

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

3D Structure

ModBase 3D Structure for O54972

Species

Mouse

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Cbfa2t3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Cbfa2t3 purchase

MBS1070785 is a recombinant protein targeting Cbfa2t3. Also known as Recombinant Mouse Protein CBFA2T3 (Cbfa2t3). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Cbfa2t3. It may not necessarily be applicable to this product.

NCBI GI #

158081729

NCBI GeneID

12398

NCBI Accession #

NP_001103343.1

UniProt Primary Accession #

O54972

UniProt Secondary Accession #

Q7TND6; Q8BZS0

UniProt Related Accession #

O54972

GenBank Nucleotide #

NM_001109873.1

NCBI Official Full Name

protein CBFA2T3 isoform 2

NCBI Official Synonym Full Names

core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)

NCBI Official Symbol

Cbfa2t3

NCBI Official Synonym Symbols

Eto2; ETO-2; MTGR2; AI465270; AW229127; Cbfa2t3h; A630044F12Rik

UniProt Protein Name

Protein CBFA2T3

UniProt Synonym Protein Names

Eight twenty one protein 2; MTG8-related protein 2; Protein ETO-2

Protein Family

Protein

UniProt Gene Name

Cbfa2t3

UniProt Synonym Gene Names

Cbfa2t3h; Mtgr2

NCBI Protein Information

protein CBFA2T3

UniProt Comments for Cbfa2t3

Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes. Can repress the expression of MMP7 in a ZBTB33-dependent manner. Reduces the protein levels and stability of the transcriptinal regulator HIF1A; interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway. Contributes to inhibition of glycolysis and stimulation of mitochondrial respiration by down-regulating the expression of glycolytic genes including PFKFB3, PFKFB4, PDK1, PFKP, LDHA and HK1 which are direct targets of HIF1A (). Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (PubMed:16407974). Plays a role in granulocyte differentiation (PubMed:15231665).

Research Articles on Cbfa2t3

1. gene deficient mice have decreased levels of systemic monocytes and infarct-associated macrophages and display compromised tissue healing and post-MI heart failure

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Cbfa2t3 recombinant protein

Reference Product	PubMed Publications
Runx1 recombinant protein	>14 publications with Cbfa2t3 and Runx1
Gata1 recombinant protein	>6 publications with Cbfa2t3 and Gata1
Ncor1 recombinant protein	>3 publications with Cbfa2t3 and Ncor1
Sin3a recombinant protein	>1 publications with Cbfa2t3 and Sin3a

Diseases associated with Cbfa2t3 recombinant protein

Disease Name	Pubmed Publications
Breast Neoplasms Antibodies	>8 publications with Cbfa2t3 and Breast Neoplasms
Inflammation Antibodies	>3 publications with Cbfa2t3 and Inflammation
Neurobehavioral Manifestations Antibodies	>1 publications with Cbfa2t3 and Neurobehavioral Manifestations
Weight Loss Antibodies	>1 publications with Cbfa2t3 and Weight Loss
Cardiovascular Diseases Antibodies	>1 publications with Cbfa2t3 and Cardiovascular Diseases
Carcinoma, Hepatocellular Antibodies	>1 publications with Cbfa2t3 and Carcinoma, Hepatocellular
Kidney Diseases Antibodies	>1 publications with Cbfa2t3 and Kidney Diseases
Drug-Induced Liver Injury Antibodies	>1 publications with Cbfa2t3 and Drug-Induced Liver Injury

Organs/Tissues associated with Cbfa2t3 recombinant protein

Organ/Tissue Name	Pubmed Publications
Bone Marrow Antibodies	>10 publications with Cbfa2t3 and Bone Marrow
Embryonic Tissue Antibodies	>4 publications with Cbfa2t3 and Embryonic Tissue
Intestine Antibodies	>3 publications with Cbfa2t3 and Intestine
Brain Antibodies	>3 publications with Cbfa2t3 and Brain
Liver Antibodies	>2 publications with Cbfa2t3 and Liver
Thymus Antibodies	>2 publications with Cbfa2t3 and Thymus
Lung Antibodies	>2 publications with Cbfa2t3 and Lung
Kidney Antibodies	>2 publications with Cbfa2t3 and Kidney
Heart Antibodies	>1 publications with Cbfa2t3 and Heart
Eye Antibodies	>1 publications with Cbfa2t3 and Eye