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Omega-Hexatoxin-Hv1a (OMEGA-HXTX-HV1A) Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1073255

Reversibly and voltage-independently blocks both mid-low- (M-LVA) and high-voltage-activated (HVA) calcium channels in cockroach DUM neurons. Lethal to many insect orders but not toxic to mice or rabbits. May target the insect high-voltage-activated calcium… More details

$455 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Omega-hexatoxin-Hv1a (Omega-HXTX-Hv1a), Recombinant Protein
Full Product Name
Recombinant Hadronyche versuta (Blue mountains funnel-web spider) (Atrax versutus) Omega-hexatoxin-Hv1a
Product Synonym Names
Omega-atracotoxin-Hv1a; AcTx-Hv1; Omega-AcTx-Hv1a
Sequence
SPTCIPSGQP CPYNENCCSQ SCTFKENENG NTVKRCD
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Molecular Weight
20.1 kDa
Sequence Positions
1-37aa; Full Length
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for P56207
Species
Hadronyche versuta (Blue mountains funnel-web spider) (Atrax versutus)
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Product References and Citations for Omega-HXTX-Hv1a recombinant protein

"The structure of a novel insecticidal neurotoxin, omega-atracotoxin-HV1, from the venom of an Australian funnel web spider." Fletcher J.I., Smith R., O'Donoghue S.I., Nilges M., Connor M., Howden M.E.H., Christie M.J., King G.F. Nat. Struct. Biol. 4:559-566(1997)

Other Notes

Small volumes of Omega-HXTX-Hv1a recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Omega-HXTX-Hv1a purchase

MBS1073255 is a recombinant protein targeting Omega-HXTX-Hv1a. Also known as Recombinant Hadronyche versuta (Blue mountains funnel-web spider) (Atrax versutus) Omega-hexatoxin-Hv1a. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Omega-HXTX-Hv1a. It may not necessarily be applicable to this product.

NCBI GI #
NCBI Accession #
UniProt Primary Accession #
NCBI Official Full Name
Omega-hexatoxin-Hv1a
UniProt Protein Name
Omega-hexatoxin-Hv1a
UniProt Synonym Protein Names
Omega-atracotoxin-Hv1a; AcTx-Hv1; Omega-AcTx-Hv1a
Protein Family
UniProt Gene Name
Omega-HXTX-Hv1a
UniProt Synonym Gene Names
AcTx-Hv1; Omega-AcTx-Hv1a
UniProt Entry Name
TO1A_HADVE

UniProt Comments for Omega-HXTX-Hv1a

Reversibly and voltage-independently blocks both mid-low- (M-LVA) and high-voltage-activated (HVA) calcium channels in cockroach DUM neurons. Lethal to many insect orders but not toxic to mice or rabbits. May target the insect high-voltage-activated calcium channel Dmca1D. Also inhibits acarines calcium channels. An extremely high toxin concentration partially inhibits Cav1.2/CACNA1C, Cav2.1/CACNA1A and Cav2.2/CACNA1B calcium channel of rats. As for omega-AcTx-Hv2a, the phenotypic effect of injection of this toxin into lone star ticks (Amblyomma americanum) is curling of all eight legs into closed loops.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
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