Envelope Protein US9 (US9) Human Herpesvirus 2 Recombinant Protein

Function: Essential for the anterograde spread of the infection throughout the host nervous system. Together with the gE/gI heterodimer, US9 is involved in the sorting and transport of viral structural components toward axon tips.

Subcellular location: Virion membrane; Single-pass type II membrane protein

By similarity. Host Golgi apparatus membrane; Single-pass type II membrane protein

By similarity. Host smooth endoplasmic reticulum membrane; Single-pass type II membrane protein

By similarity. Host cell membrane; Single-pass type II membrane protein

Potential. Note: During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN), maybe through an interaction with PACS-1 sorting protein.

Post-translational modification: Phosphorylated on serines within the acidic cluster, possibly by host CK2

Potential. Phosphorylation determines whether endocytosed viral US9 traffics to the trans-Golgi network or recycles to the cell membrane

Potential.

Sequence similarities: Belongs to the alphaherpesvirinae envelope protein US9 family.