• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Alpha-1a Adrenergic Receptor (ADRA1A) Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS7042090

This is a recombinant transmembrane protein expressed in a cell-free expression system. More details

$1860 / 0.02 mg +2 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Alpha-1A adrenergic receptor (Adra1a), Recombinant Protein
Full Product Name
Alpha-1A adrenergic receptor
Product Gene Name
Adra1a recombinant protein
Sequence
MVLLSENASE GSNCTHPPAP VNISKAILLG VILGGLIIFG VLGNILVILS VACHRHLHSV THYYIVNLAV ADLLLTSTVL PFSAIFEILG YWAFGRVFCN IWAAVDVLCC TASIMGLCII SIDRYIGVSY PLRYPTIVTQ RRGVRALLCV WVLSLVISIG PLFGWRQPAP EDETICQINE EPGYVLFSAL GSFYVPLAII LVMYCRVYVV AKRESRGLKS GLKTDKSDSE QVTLRIHRKN VPAEGGGVSS AKNKTHFSVR LLKFSREKKA AKTLGIVVGC FVLCWLPFFL VMPIGSFFPD FKPSETVFKI VFWLGYLNSC INPIIYPCSS QEFKKAFQNV LRIQCLRRRQ SSKHALGYTL HPPSQALEGQ HRDMVRIPVG SGETFYKISK TDGVCEWKFF SSMPQGSARI TVPKDQSACT TARVRSKSFL QVCCCVGSSA PRPEENHQVP TIKIHTISLG ENGEEV
Host
Cell Free Expression
Form/Format
Liquid containing glycerol
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
Molecular Weight
51,598 Da
Sequence Positions
1-466aa, Full-Length
3D Structure
ModBase 3D Structure for P43140
Species
Rattus norvegicus (Rat)

Product Categories/Family for Adra1a recombinant protein

Transmembrane Protein
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Adra1a recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Adra1a purchase

MBS7042090 is a recombinant protein targeting Adra1a. Also known as Alpha-1A adrenergic receptor. Host: Cell Free Expression.

Additional Details

NCBI/Uniprot data below describe general gene information for Adra1a. It may not necessarily be applicable to this product.

NCBI GI #
148747171
NCBI GeneID
29412
NCBI Accession #
NP_058887.2
UniProt Primary Accession #
P43140
UniProt Related Accession #
P43140
GenBank Nucleotide #
NM_017191.2
NCBI Official Full Name
alpha-1A adrenergic receptor
NCBI Official Synonym Full Names
adrenoceptor alpha 1A
NCBI Official Symbol
Adra1a
NCBI Official Synonym Symbols
Adra1c
UniProt Protein Name
Alpha-1A adrenergic receptor
UniProt Synonym Protein Names
Alpha-1A adrenoreceptor; Alpha-1A adrenoceptor; Alpha-1C adrenergic receptor
Protein Family
Alpha-1A adrenergic receptor
UniProt Gene Name
Adra1a
UniProt Synonym Gene Names
Adra1c; Alpha-1A adrenoceptor
UniProt Entry Name
ADA1A_RAT
NCBI Protein Information
alpha-1A adrenergic receptor

NCBI Summary for Adra1a

binds adrenergic compounds and analogs; activates phospholipase C mediated signal transduction [RGD, Feb 2006]

UniProt Comments for Adra1a

ADRA1A: This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1A sub-subfamily. 9 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral; GPCR, family 1

Cellular Component: integral to plasma membrane; membrane; nuclear membrane; nucleus; plasma membrane; T-tubule; Z disc

Molecular Function: alpha1-adrenergic receptor activity; protein heterodimerization activity

Biological Process: adult heart development; aging; cell growth; elevation of cytosolic calcium ion concentration; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); micturition; negative regulation of heart rate in baroreceptor response to increased systemic arterial blood pressure; negative regulation of Rho protein signal transduction; norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure; organ growth; phospholipase C activation; positive regulation of action potential; positive regulation of heart rate; positive regulation of heart rate by epinephrine-norepinephrine; positive regulation of MAPKKK cascade; positive regulation of smooth muscle contraction; positive regulation of synaptic transmission, GABAergic; positive regulation of systemic arterial blood pressure; positive regulation of the force of heart contraction by epinephrine-norepinephrine; positive regulation of vasoconstriction; response to drug; response to hormone stimulus
Show more

Research Articles on Adra1a

1. Silodosin, a selective alpha(1A)-adrenoceptor antagonist, improves voiding behavior in rat models with BOO by inducing recovery of bladder blood flow.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Adra1a recombinant protein

 Reference Product  PubMed Publications
 Htr2a recombinant protein  >2 publications with Adra1a and Htr2a
 Adrbk1 recombinant protein  >2 publications with Adra1a and Adrbk1
 P2ry2 recombinant protein  >1 publications with Adra1a and P2ry2
 Agt recombinant protein  >1 publications with Adra1a and Agt

Pathways associated with Adra1a recombinant protein

 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenoceptors Pathway antibodies  Adrenoceptors Pathway Diagram
 Amine Ligand-binding Receptors Pathway antibodies  Amine Ligand-binding Receptors Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram

Diseases associated with Adra1a recombinant protein

 Disease Name  Pubmed Publications
 Hyperplasia Antibodies  >39 publications with Adra1a and Hyperplasia
 Prostatic Hyperplasia Antibodies  >39 publications with Adra1a and Prostatic Hyperplasia
 Hypertension Antibodies  >22 publications with Adra1a and Hypertension
 Heart Diseases Antibodies  >21 publications with Adra1a and Heart Diseases
 Urologic Diseases Antibodies  >20 publications with Adra1a and Urologic Diseases
 Heart Failure Antibodies  >12 publications with Adra1a and Heart Failure
 Cardiomegaly Antibodies  >10 publications with Adra1a and Cardiomegaly
 Cardiomyopathies Antibodies  >7 publications with Adra1a and Cardiomyopathies
 Pain Antibodies  >6 publications with Adra1a and Pain
 Hypotension Antibodies  >5 publications with Adra1a and Hypotension

Organs/Tissues associated with Adra1a recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >66 publications with Adra1a and Heart
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000