Bcl-xL: an antiapoptotic member of the Bcl-2 family. Located at the outer mitochondrial membrane and regulates outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are potent inducers of cell apoptosis. Two alternatively spliced isoforms have been reported.
Protein type: Autophagy; Membrane protein, integral; Mitochondrial; Apoptosis
Cellular Component: mitochondrial envelope; centrosome; nuclear membrane; mitochondrion; synaptic vesicle membrane; integral to membrane; cytosol; mitochondrial outer membrane; mitochondrial matrix; mitochondrial membrane; mitochondrial inner membrane; cytoplasm; nucleolus; intracellular; cell junction; nucleus
Molecular Function: identical protein binding; BH domain binding; protein binding; protein homodimerization activity; protein heterodimerization activity; caspase inhibitor activity; BH3 domain binding; protein kinase binding
Biological Process: response to peptide hormone stimulus; positive regulation of apoptosis; apoptosis; negative regulation of caspase activity; cellular process regulating host cell cycle in response to virus; response to organic cyclic substance; germ cell development; regulation of apoptosis; response to radiation; regulation of mitochondrial membrane potential; ovarian follicle development; positive regulation of cell proliferation; negative regulation of neuron apoptosis; response to electrical stimulus; release of cytochrome c from mitochondria; response to inorganic substance; in utero embryonic development; response to virus; mitotic cell cycle checkpoint; suppression by virus of host apoptosis; male gonad development; endocytosis; response to organic nitrogen; cell proliferation; neuron apoptosis; fertilization; DNA damage response, signal transduction resulting in induction of apoptosis; response to hydrogen peroxide; response to cytokine stimulus; response to lead ion; response to hypoxia; response to cycloheximide; spermatogenesis; response to oxidative stress; regulation of mitochondrial membrane permeability; growth; negative regulation of apoptosis
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