Drosophila Melanogaster tsr Recombinant Protein – Cat# MBS1085918

Cofilin/Actin-Depolymerizing Factor Homolog (tsr) Drosophila Melanogaster Recombinant Protein

Name: tsr Recombinant Protein; Drosophila Melanogaster; MyBioSource
Brand: MyBioSource
SKU: MBS1085918
Price: 800 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1085918

MBS1085918 is a recombinant protein targeting tsr. Also known as Recombinant Drosophila melanogaster Cofilin/actin-depolymerizing factor homolog (tsr). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$800 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Cofilin/actin-depolymerizing factor homolog (tsr), Recombinant Protein

Full Product Name

Recombinant Drosophila melanogaster Cofilin/actin-depolymerizing factor homolog (tsr)

Product Gene Name

tsr recombinant protein

Sequence

MASGVTVSDV CKTTYEEIKK DKKHRYVIFY IRDEKQIDVE TVADRNAEYD QFLEDIQKCG PGECRYGLFD FEYMHQCQGT SESSKKQKLF LMSWCPDTAK VKKKMLYSSS FDALKKSLVG VQKYIQATDL SEASREAVEE KLRATDRQ

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

17,153 Da

Sequence Positions

1-148, Full length protein

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

3D Structure

ModBase 3D Structure for P45594

Species

Drosophila melanogaster (Fruit fly)

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of tsr recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for tsr. It may not necessarily be applicable to this product.

NCBI GI #

17136986

NCBI GeneID

37841

NCBI Accession #

NP_477034.1

UniProt Primary Accession #

P45594

UniProt Secondary Accession #

Q9W1C4; C6SV25

UniProt Related Accession #

P45594

GenBank Nucleotide #

NM_057686.4

NCBI Official Full Name

twinstar

NCBI Official Synonym Full Names

twinstar

NCBI Official Symbol

tsr

NCBI Official Synonym Symbols

12/8; Adf; ADF; ADF/cofilin; Cadf; CG4254; cofilin; cofilin/actin depolymerizing factor homolog; cofilin/ADF; D-cof; D61; DmelCG4254; l(2)03101; l(2)k03101; l(2)k05633; l(2)k13409; ntf; T8; Tsr

UniProt Protein Name

Cofilin/actin-depolymerizing factor homolog

UniProt Synonym Protein Names

Protein D61; Protein twinstar

Protein Family

Cofilin/actin-depolymerizing factor

UniProt Gene Name

tsr

NCBI Protein Information

CG4254 gene product from transcript CG4254-RA

UniProt Comments for tsr

Exhibits F-actin depolymerizing activity and regulates actin cytoskeleton dynamics (PubMed:21205790). Required for cytokinesis in both mitotic and meiotic cells and for aster migration and separation (PubMed:8522587). Promotes cell motility during ovary development and oogenesis (PubMed:11175754). During larval development, required for the cell rearrangement needed for formation of terminal filaments which are stacks of somatic cells that are important for the initiation of ovarioles (PubMed:11175754). Also required for border cell migration during oogenesis (PubMed:11175754). During border cell migration, required for actin turnover and lamellipodial protrusion (PubMed:21205790). Required for the establishment of planar cell polarity (PCP) where cells adopt a uniform orientation within the plane of an epithelium (PubMed:16571634). During establishment of PCP, required for the redistribution of the PCP core proteins fz and stan/fmi to the proximodistal cell boundary (PubMed:16571634). During pupal development, required for elongation of the retinal cell body and for rhabdomere morphogenesis (PubMed:18423434). Required for mushroom body neuroblast proliferation and axon growth (PubMed:15572110). Plays a role in the positive regulation of protein secretion (PubMed:20026655). Plays a role in the regulation of nuclear localization of actin (PubMed:22323606). Required for the maintenance of epithelial integrity by controlling cell junctions and is also necessary for cell survival and tissue growth through regulation of JNK and yki signaling (PubMed:27041568).

Research Articles on tsr

1. Taken together, our data suggest that Tsr is required for cell survival and tissue growth by regulating JNK and Yki signaling while maintaining the epithelial integrity by controlling cell junctions. This study provides an insight into potential roles of ADF/cofilin in invasive cell migration and tumor suppression in higher animals.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with tsr recombinant protein

Reference Product	PubMed Publications
flr recombinant protein	>1 publications with tsr and flr
capt recombinant protein	>1 publications with tsr and capt

Pathways associated with tsr recombinant protein

Products by Pathway	Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
Developmental Biology Pathway antibodies	Developmental Biology Pathway Diagram
EPH-Ephrin Signaling Pathway antibodies	EPH-Ephrin Signaling Pathway Diagram
EPHB-mediated Forward Signaling Pathway antibodies	EPHB-mediated Forward Signaling Pathway Diagram
Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway antibodies	Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway Diagram
Hemostasis Pathway antibodies	Hemostasis Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Innate Immune System Pathway antibodies	Innate Immune System Pathway Diagram
Platelet Activation, Signaling And Aggregation Pathway antibodies	Platelet Activation, Signaling And Aggregation Pathway Diagram
Platelet Degranulation Pathway antibodies	Platelet Degranulation Pathway Diagram

Organs/Tissues associated with tsr recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>104 publications with tsr and Blood
Head Antibodies	>20 publications with tsr and Head
Embryonic Tissue Antibodies	>14 publications with tsr and Embryonic Tissue
Testis Antibodies	>5 publications with tsr and Testis
Ovary Antibodies	>5 publications with tsr and Ovary
Gonad Antibodies	>5 publications with tsr and Gonad
Fat Body Antibodies	>3 publications with tsr and Fat Body