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Collagen XXV Alpha1 (COL25A1) Antibody – Rabbit

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS001086

MBS001086 is an antibody targeting COL25A1. Also known as Rabbit Collagen XXV alpha1 Antibody. Reactive in Human, mouse. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
Collagen XXV alpha1 (COL25A1), Antibody
Full Product Name
Rabbit Collagen XXV alpha1 Antibody
Product Gene Name
Product Synonym Names
Collagen XXV a1
Host
Rabbit
Species Reactivity
Human, mouse
Form/Format
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
Concentration
1 mg/ml (lot specific)
Molecular Weight
64,771 Da
Chromosome Location
Chromosome: 4; NC_000004.11 (109731877..110223799, complement). Location: 4q25
OMIM
610004
3D Structure
ModBase 3D Structure for Q9BXS0
Applications Tested/Suitable for anti-COL25A1 antibody
ELISA (EIA), Western Blot (WB)

Other Notes

Small volumes of anti-COL25A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for COL25A1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
collagen alpha-1(XXV) chain isoform 2
NCBI Official Synonym Full Names
collagen, type XXV, alpha 1
NCBI Official Symbol
COL25A1
NCBI Official Synonym Symbols
AMY; CLAC; CLACP; CLAC-P
UniProt Protein Name
Collagen alpha-1(XXV) chain
UniProt Synonym Protein Names
Alzheimer disease amyloid-associated protein; AMY; CLAC-P
UniProt Gene Name
COL25A1
UniProt Synonym Gene Names
AMY; CLAC
UniProt Entry Name
COPA1_HUMAN
NCBI Protein Information
collagen alpha-1(XXV) chain; collagen alpha-1(XXV) chain; alzheimer disease amyloid-associated protein; collagenous Alzheimer amyloid plaque component; collagen-like Alzheimer amyloid plaque component

NCBI Summary for COL25A1

This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
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UniProt Comments for COL25A1

COL25A1: Inhibits fibrillization of beta amyloid peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 4q25

Cellular Component: extracellular space; collagen; integral to plasma membrane; endoplasmic reticulum lumen; integral to membrane; plasma membrane; extracellular region

Molecular Function: heparin binding; beta-amyloid binding

Biological Process: collagen catabolic process; extracellular matrix disassembly; extracellular matrix organization and biogenesis

Disease: Fibrosis Of Extraocular Muscles, Congenital, 5
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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