Human CILPUNQ602 Recombinant Protein – Cat# MBS1087099

Cartilage Intermediate Layer Protein 1 (CILP) (CILPUNQ602) Human Recombinant Protein

Name: CILPUNQ602 Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1087099
Price: 440 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1087099

MBS1087099 is a recombinant protein targeting CILPUNQ602. Also known as Recombinant Human Cartilage intermediate layer protein 1 (CILP), partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$440 / 0.02 mg (Yeast) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Cartilage intermediate layer protein 1 (CILP) (CILPUNQ602), Recombinant Protein

Full Product Name

Recombinant Human Cartilage intermediate layer protein 1 (CILP), partial

Product Gene Name

CILPUNQ602 recombinant protein

Sequence

EDRTFLVGNL EIRERRLFNL DVPESRRCFV KVRAYRSERF LPSEQIQGVV ISVINLEPRT GFLSNPRAWG RFDSVITGPN GACVPAFCDD QSPDAYSAYV LASLAGEELQ AVESSPKFNP NAIGVPQPYL NKLNYRRTDH EDPRVKKTAF QISMAKPRPN SAEESNGPIY AFENLRACEE APPSAAHFRF YQIEGDRYDY NTVPFNEDDP MSWTEDYLAW WPKPMEFRAC YIKVKIVGPL EVNVRSRNMG GTHRQTVGKL YGIRDVRSTR DRDQPNVSAA CLEFKCSGML YDQDRVDRTL VKVIPQGSCR RASVNPMLHE YLVNHLPLAV NNDTSEYTML APLDPLGHNY GIYTVTDQDP RTAKEIALGR CFDGTSDGSS RIMKSNVGVA LTFNCVERQV GRQSAFQYLQ STPAQSPAAG TVQGRVPSRR QQRASRGGQR QGGVVASLRF PRVAQQPLIN

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

53.7 kDa

Sequence Positions

725-1184. Partial, provide the Cartilage intermediate layer protein 1 C2 chain.

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

603489

3D Structure

ModBase 3D Structure for O75339

Species

Homo sapiens (Human)

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of CILPUNQ602 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CILPUNQ602. It may not necessarily be applicable to this product.

NCBI GI #

192449445

NCBI GeneID

8483

NCBI Accession #

NP_003604.3

UniProt Primary Accession #

O75339

UniProt Secondary Accession #

Q6UW99; Q8IYI5; B2R8F7

UniProt Related Accession #

O75339

GenBank Nucleotide #

NM_003613.3

NCBI Official Full Name

cartilage intermediate layer protein 1 preproprotein

NCBI Official Synonym Full Names

cartilage intermediate layer protein

NCBI Official Symbol

CILP

NCBI Official Synonym Symbols

CILP-1; HsT18872

UniProt Protein Name

Cartilage intermediate layer protein 1

UniProt Synonym Protein Names

Cartilage intermediate-layer protein

Protein Family

Cartilage intermediate layer protein

UniProt Gene Name

CILP

UniProt Synonym Gene Names

CILP-1

NCBI Protein Information

cartilage intermediate layer protein 1

NCBI Summary for CILPUNQ602

Major alterations in the composition of the cartilage extracellular matrix occur in joint disease, such as osteoarthrosis. This gene encodes the cartilage intermediate layer protein (CILP), which increases in early osteoarthrosis cartilage. The encoded protein was thought to encode a protein precursor for two different proteins; an N-terminal CILP and a C-terminal homolog of NTPPHase, however, later studies identified no nucleotide pyrophosphatase phosphodiesterase (NPP) activity. The full-length and the N-terminal domain of this protein was shown to function as an IGF-1 antagonist. An allelic variant of this gene has been associated with lumbar disc disease. [provided by RefSeq, Sep 2010]

UniProt Comments for CILPUNQ602

Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage.

Research Articles on CILPUNQ602

1. CILP rs2073711 TT is associated with increased risk of symmetrical hand osteoarthritis particularly in individuals with low variation in work tasks.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CILPUNQ602 recombinant protein

Reference Product	PubMed Publications
BMP2 recombinant protein	>2 publications with CILPUNQ602 and BMP2
FURIN recombinant protein	>1 publications with CILPUNQ602 and FURIN
COL9A2 recombinant protein	>1 publications with CILPUNQ602 and COL9A2
COL9A3 recombinant protein	>1 publications with CILPUNQ602 and COL9A3

Diseases associated with CILPUNQ602 recombinant protein

Disease Name	Pubmed Publications
Disease Models, Animal Antibodies	>3 publications with CILPUNQ602 and Disease Models, Animal
Cardiovascular Diseases Antibodies	>2 publications with CILPUNQ602 and Cardiovascular Diseases
Inflammation Antibodies	>2 publications with CILPUNQ602 and Inflammation
Genital Diseases, Female Antibodies	>1 publications with CILPUNQ602 and Genital Diseases, Female
Intervertebral disc disease Antibodies	>1 publications with CILPUNQ602 and Intervertebral disc disease

Organs/Tissues associated with CILPUNQ602 recombinant protein

Organ/Tissue Name	Pubmed Publications
Connective Tissue Antibodies	>7 publications with CILPUNQ602 and Connective Tissue
Muscle Antibodies	>1 publications with CILPUNQ602 and Muscle
Trachea Antibodies	>1 publications with CILPUNQ602 and Trachea
Brain Antibodies	>1 publications with CILPUNQ602 and Brain
Heart Antibodies	>1 publications with CILPUNQ602 and Heart