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U4/U6.u5 Tri-Snrnp-Associated Protein 1 (SART1) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1088644

This gene encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. The SART1(259) protein is translated by the mechanism of -1… More details

$1680 / 0.02 mg (E-Coli) +2 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
U4/U6.U5 tri-snRNP-associated protein 1 (SART1), Recombinant Protein
Full Product Name
Recombinant Human U4/U6.U5 tri-snRNP-associated protein 1 (SART1)
Product Gene Name
SART1 recombinant protein
Sequence
MGSSKKHRGE KEAAGTTAAA GTGGATEQPP RHREHKKHKH RSGGSGGSGG ERRKRSRERG GERGSGRRGA EAEARSSTHG RERSQAEPSE RRVKREKRDD GYEAAASSKT SSGDASSLSI EETNKLRAKL GLKPLEVNAI KKEAGTKEEP VTADVINPMA LRQREELREK LAAAKEKRLL NQKLGKIKTL GEDDPWLDDT AAWIERSRQL QKEKDLAEKR AKLLEEMDQE FGVSTLVEEE FGQRRQDLYS ARDLQGLTVE HAIDSFREGE TMILTLKDKG VLQEEEDVLV NVNLVDKERA EKNVELRKKK PDYLPYAEDE SVDDLAQQKP RSILSKYDEE LEGERPHSFR LEQGGTADGL RERELEEIRA KLRLQAQSLS TVGPRLASEY LTPEEMVTFK KTKRRVKKIR KKEKEVVVRA DDLLPLGDQT QDGDFGSRLR GRGRRRVSEV EEEKEPVPQP LPSDDTRVEN MDISDEEEGG APPPGSPQVL EEDEAELELQ KQLEKGRRLR QLQQLQQLRD SGEKVVEIVK KLESRQRGWE EDEDPERKGA IVFNATSEFC RTLGEIPTYG LAGNREEQEE LMDFERDEER SANGGSESDG EENIGWSTVN LDEEKQQQDF SASSTTILDE EPIVNRGLAA ALLLCQNKGL LETTVQKVAR VKAPNKSLPS AVYCIEDKMA IDDKYSRREE YRGFTQDFKE KDGYKPDVKI EYVDETGRKL TPKEAFRQLS HRFHGKGSGK MKTERRMKKL DEEALLKKMS SSDTPLGTVA LLQEKQKAQK TPYIVLSGSG KSMNANTITK
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
90,255 Da
Sequence Positions
1-800, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
605941
3D Structure
ModBase 3D Structure for O43290
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of SART1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SART1 purchase

MBS1088644 is a recombinant protein targeting SART1. Also known as Recombinant Human U4/U6.U5 tri-snRNP-associated protein 1 (SART1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for SART1. It may not necessarily be applicable to this product.

NCBI GI #
10863889
NCBI GeneID
9092
NCBI Accession #
NP_005137.1
UniProt Primary Accession #
O43290
UniProt Secondary Accession #
Q53GB5; A6NDN1
UniProt Related Accession #
O43290
GenBank Nucleotide #
NM_005146.4
NCBI Official Full Name
U4/U6.U5 tri-snRNP-associated protein 1
NCBI Official Synonym Full Names
SART1, U4/U6.U5 tri-snRNP-associated protein 1
NCBI Official Symbol
SART1
NCBI Official Synonym Symbols
HAF; Ara1; HOMS1; Snu66; SART1259; SNRNP110
UniProt Protein Name
U4/U6.U5 tri-snRNP-associated protein 1
UniProt Synonym Protein Names
SNU66 homolog; hSnu66; Squamous cell carcinoma antigen recognized by T-cells 1; SART-1; hSART-1; U4/U6.U5 tri-snRNP-associated 110 kDa protein; Allergen: Hom s 1
Protein Family
U4/U6.U5 tri-snRNP-associated protein
UniProt Gene Name
SART1
UniProt Synonym Gene Names
hSnu66; SART-1; hSART-1
NCBI Protein Information
U4/U6.U5 tri-snRNP-associated protein 1

NCBI Summary for SART1

This gene encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. The SART1(259) protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation; its full-length sequence is not published yet. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens. The SART1(259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1(259) antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1(259) protein is found to be essential for the recruitment of the tri-snRNP to the pre-spliceosome in the spliceosome assembly pathway. [provided by RefSeq, Jul 2008]
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UniProt Comments for SART1

Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA.

Research Articles on SART1

1. SART1 has a role in IFN-mediated anti-Hepatitis B virus response

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with SART1 recombinant protein

 Reference Product  PubMed Publications
 PRPF4 recombinant protein  >1 publications with SART1 and PRPF4
 MFAP1 recombinant protein  >1 publications with SART1 and MFAP1
 SNW1 recombinant protein  >1 publications with SART1 and SNW1
 UBL5 recombinant protein  >1 publications with SART1 and UBL5

Pathways associated with SART1 recombinant protein

 Products by Pathway  Pathway Diagram
 Spliceosome Pathway antibodies  Spliceosome Pathway Diagram
 Spliceosome Pathway antibodies  Spliceosome Pathway Diagram
 Spliceosome, U4/U6.U5 Tri-snRNP Pathway antibodies  Spliceosome, U4/U6.U5 Tri-snRNP Pathway Diagram
 Spliceosome, U4/U6.U5 Tri-snRNP Pathway antibodies  Spliceosome, U4/U6.U5 Tri-snRNP Pathway Diagram

Diseases associated with SART1 recombinant protein

 Disease Name  Pubmed Publications
 Hepatitis Antibodies  >4 publications with SART1 and Hepatitis
 Breast Neoplasms Antibodies  >3 publications with SART1 and Breast Neoplasms
 Liver Diseases Antibodies  >3 publications with SART1 and Liver Diseases
 Lung Neoplasms Antibodies  >2 publications with SART1 and Lung Neoplasms
 Neoplasm Metastasis Antibodies  >2 publications with SART1 and Neoplasm Metastasis
 Kidney Diseases Antibodies  >2 publications with SART1 and Kidney Diseases
 Carcinoma, Hepatocellular Antibodies  >2 publications with SART1 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >2 publications with SART1 and Liver Neoplasms
 Necrosis Antibodies  >2 publications with SART1 and Necrosis
 Liver Cirrhosis Antibodies  >1 publications with SART1 and Liver Cirrhosis

Organs/Tissues associated with SART1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >21 publications with SART1 and Blood
 Liver Antibodies  >5 publications with SART1 and Liver
 Brain Antibodies  >4 publications with SART1 and Brain
 Lung Antibodies  >3 publications with SART1 and Lung
 Mouth Antibodies  >2 publications with SART1 and Mouth
 Kidney Antibodies  >2 publications with SART1 and Kidney
 Esophagus Antibodies  >2 publications with SART1 and Esophagus
 Testis Antibodies  >2 publications with SART1 and Testis
 Bone Antibodies  >2 publications with SART1 and Bone
 Vascular Antibodies  >2 publications with SART1 and Vascular
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