Caenorhabditis Elegans hif-1 Recombinant Protein – Cat# MBS1089271

Hypoxia-Inducible Factor 1 (hif-1) Caenorhabditis Elegans Recombinant Protein

Name: hif-1 Recombinant Protein; Caenorhabditis Elegans; MyBioSource
Brand: MyBioSource
SKU: MBS1089271
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1089271

MBS1089271 is a recombinant protein targeting hif-1. Also known as Recombinant Caenorhabditis elegans Hypoxia-inducible factor 1 (hif-1), partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Hypoxia-inducible factor 1 (hif-1), Recombinant Protein

Full Product Name

Recombinant Caenorhabditis elegans Hypoxia-inducible factor 1 (hif-1), partial

Product Gene Name

hif-1 recombinant protein

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

78,890 Da

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

3D Structure

ModBase 3D Structure for G5EGD2

Species

Caenorhabditis elegans

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of hif-1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for hif-1. It may not necessarily be applicable to this product.

NCBI GI #

193207993

NCBI GeneID

180359

NCBI Accession #

NP_001023891.2

UniProt Primary Accession #

G5EGD2

UniProt Secondary Accession #

Q8I4D0; G5ECE6; G5EDZ3; G5EE28

UniProt Related Accession #

G5EGD2

GenBank Nucleotide #

NM_001028720.3

NCBI Official Full Name

Hypoxia-inducible factor 1

NCBI Official Symbol

hif-1

UniProt Protein Name

Hypoxia-inducible factor 1

UniProt Synonym Protein Names

Hypoxia-induced factor 1

Protein Family

Hypoxia-inducible factor

UniProt Gene Name

hif-1

NCBI Protein Information

HIF (Hypoxia Inducible Factor) homologa; Hypoxia-inducible factor 1

UniProt Comments for hif-1

A transcription factor which is a key regulator in various cellular processes; including environment stress resistance (oxygen levels, hydrogen sulfide and cyanide levels and heat), negative regulation of cell apoptosis in ASJ neurons by inhibition of cep-1 via transcriptional activation of tyr-2, resistance/susceptibility to pathogenic bacteria, lifespan and brood size (PubMed:11427734, PubMed:12006646, PubMed:12686697, PubMed:15781453, PubMed:18477695, PubMed:19461873, PubMed:21093262, PubMed:19889840, PubMed:20520707, PubMed:20400959). Involved in mediating susceptibility to enteropathogenic E.coli (PubMed:16091039). Increased levels of hif-1 activity confer resistance to P.aeruginosa-mediated death but also confer susceptibility to S.aureus infection (PubMed:20865124, PubMed:22792069). Required for aha-1 nuclear localization (PubMed:11427734). Following hypoxic stress, up-regulates serotonin levels through activation of tph-1 expression (PubMed:20400959). Role in life span extension is dependent of temperature (PubMed:21241450). Not required for survival in anoxic conditions (PubMed:11427734). Involved in iron homeostasis by repressing transcription of ferritin ftn-1 and ftn-2, and divalent metal transporter smf-3 (PubMed:22396654, PubMed:22194696). May be involved in manganese homeostasis by repressing divalent metal transporter smf-3 (PubMed:22194696).

Research Articles on hif-1

1. Our results suggest that these detoxification pathways are mediated by the hypoxia inducible factor HIF-1. Finally, we show that sulfide resistance varies among wild C. elegans and other nematode species, suggesting that tolerance to sulfide was naturally selected in certain habitats.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with hif-1 recombinant protein

Reference Product	PubMed Publications
FLNA recombinant protein	>12 publications with hif-1 and FLNA

Pathways associated with hif-1 recombinant protein

Products by Pathway	Pathway Diagram
Cellular Response To Hypoxia Pathway antibodies	Cellular Response To Hypoxia Pathway Diagram
Cellular Responses To Stress Pathway antibodies	Cellular Responses To Stress Pathway Diagram
Circadian Clock Pathway antibodies	Circadian Clock Pathway Diagram
Oxygen-dependent Proline Hydroxylation Of Hypoxia-inducible Factor Alpha Pathway antibodies	Oxygen-dependent Proline Hydroxylation Of Hypoxia-inducible Factor Alpha Pathway Diagram
Regulation Of Hypoxia-inducible Factor (HIF) By Oxygen Pathway antibodies	Regulation Of Hypoxia-inducible Factor (HIF) By Oxygen Pathway Diagram
Regulation Of Gene Expression By Hypoxia-inducible Factor Pathway antibodies	Regulation Of Gene Expression By Hypoxia-inducible Factor Pathway Diagram
Sulfide Oxidation Pathway antibodies	Sulfide Oxidation Pathway Diagram
TOR Signaling Pathway antibodies	TOR Signaling Pathway Diagram
MTOR Signaling Pathway antibodies	MTOR Signaling Pathway Diagram
MTOR Signaling Pathway antibodies	MTOR Signaling Pathway Diagram

Diseases associated with hif-1 recombinant protein

Disease Name	Pubmed Publications
Anoxia Antibodies	>2155 publications with hif-1 and Anoxia
Inflammation Antibodies	>761 publications with hif-1 and Inflammation
Kidney Diseases Antibodies	>569 publications with hif-1 and Kidney Diseases
Lung Diseases Antibodies	>529 publications with hif-1 and Lung Diseases
Protein Deficiency Antibodies	>518 publications with hif-1 and Protein Deficiency
Necrosis Antibodies	>486 publications with hif-1 and Necrosis
Heart Diseases Antibodies	>405 publications with hif-1 and Heart Diseases
Immune System Diseases Antibodies	>211 publications with hif-1 and Immune System Diseases
Edema Antibodies	>120 publications with hif-1 and Edema
Diabetes Complications Antibodies	>101 publications with hif-1 and Diabetes Complications

Organs/Tissues associated with hif-1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Embryo Antibodies	>573 publications with hif-1 and Embryo
Unknown Developmental Stage Antibodies	>1 publications with hif-1 and Unknown Developmental Stage