Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1c () Recombinant Protein

Function: The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart

By similarity.

Subunit structure: Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity.

Subcellular location: Membrane; Multi-pass membrane protein.

Domain: Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.Binding of intracellular calcium through the EF-hand motif inhibits the opening of the channel

By similarity.

Post-translational modification: Phosphorylation by PKA activates the channel

By similarity.

Sequence similarities: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1C subfamily. [View classification]