Lipid Phosphate Phosphohydrolase 3 (PPAP2B) Human Recombinant Protein

The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is a membrane glycoprotein localized at the cell plasma membrane. It has been shown to actively hydrolyze extracellular lysophosphatidic acid and short-chain phosphatidic acid. The expression of this gene is found to be enhanced by epidermal growth factor in Hela cells. [provided by RefSeq, Mar 2010]

PPAP2B: Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1- phosphate (S-1-P). The relative catalytic efficiency is LPA = PA > C-1-P > S-1-P. May be involved in cell adhesion and in cell-cell interactions. Belongs to the PA-phosphatase related phosphoesterase family.

Protein type: Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Membrane protein, multi-pass; Membrane protein, integral; Phosphatase, lipid; Lipid Metabolism - sphingolipid; EC 3.1.3.4; Lipid Metabolism - glycerolipid; Lipid Metabolism - ether lipid

Chromosomal Location of Human Ortholog: 1p32.2

Cellular Component: Golgi apparatus; adherens junction; membrane; plasma membrane; integral to membrane

Molecular Function: integrin binding; protein binding; phosphatidate phosphatase activity; lipid phosphatase activity; phosphoprotein phosphatase activity; sphingosine-1-phosphate phosphatase activity

Biological Process: blood vessel development; sphingolipid metabolic process; protein stabilization; sphingolipid biosynthetic process; regulation of Wnt receptor signaling pathway; gastrulation with mouth forming second; positive regulation of peptidyl-tyrosine phosphorylation; Bergmann glial cell differentiation; dephosphorylation; negative regulation of protein amino acid phosphorylation; phospholipid metabolic process; germ cell migration; homotypic cell-cell adhesion; positive regulation of transcription factor activity; lipid metabolic process