Serine Protease HTRA2, Mitochondrial (Htra2) (DgriGH13631) Drosophila Grimshawi Recombinant Protein

Function: Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Can antagonize antiapoptotic activity of th by directly inducing the degradation of th

By similarity. UniProtKB Q9VFJ3

Catalytic activity: Cleavage of non-polar aliphatic amino-acids at the P1 position, with a preference for Val, Ile and Met. At the P2 and P3 positions, Arg is selected most strongly with a secondary preference for other hydrophilic residues.

Subunit structure: Interacts with th/DIAP1 (via BIR 2 domain)

By similarity. UniProtKB Q9VFJ3

Subcellular location: Mitochondrion intermembrane space; Single-pass membrane protein

By similarity. Mitochondrion membrane; Single-pass membrane protein

Potential.

Sequence similarities: Belongs to the peptidase S1B family.Contains 1 PDZ (DHR) domain.