Human PSMD10 Recombinant Protein – Cat# MBS1104315

26s Proteasome Non-Atpase Regulatory Subunit 10 (PSMD10) Human Recombinant Protein

Name: PSMD10 Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1104315
Price: 455 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1104315

$455 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

26S proteasome non-ATPase regulatory subunit 10 (PSMD10), Recombinant Protein

Full Product Name

Recombinant Human 26S proteasome non-ATPase regulatory subunit 10

Product Gene Name

PSMD10 recombinant protein

Product Synonym Names

26S proteasome regulatory subunit p28; Gankyrin; p28(GANK)

Sequence

MEGCVSNLMV CNLAYSGKLE ELKESILADK SLATRTDQDS RTALHWACSA GHTEIVEFLL QLGVPVNDKD DAGWSPLHIA ASAGRDEIVK ALLGKGAQVN AVNQNGCTPL HYAASKNRHE IAVMLLEGGA NPDAKDHYEA TAMHRAAAKG NLKMIHILLY YKASTNIQDT EGNTPLHLAC DEERVEEAKL LVSQGASIYI ENKEEKTPLQ VAKGGLGLIL KRMVEG

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

Molecular Weight

40.4 kDa

Sequence Positions

1-226aa; Full Length

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

300880

3D Structure

ModBase 3D Structure for O75832

Product Categories/Family for PSMD10 recombinant protein

Cancer

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Product References and Citations for PSMD10 recombinant protein

cDNA cloning and functional analysis of p28 (Nas6p)

Other Notes

Small volumes of PSMD10 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PSMD10 purchase

MBS1104315 is a recombinant protein targeting PSMD10. Also known as Recombinant Human 26S proteasome non-ATPase regulatory subunit 10. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for PSMD10. It may not necessarily be applicable to this product.

NCBI GI #

4506217

NCBI GeneID

5716

NCBI Accession #

NP_002805.1

UniProt Primary Accession #

O75832

UniProt Secondary Accession #

Q5U0B2; Q8IZK9

UniProt Related Accession #

O75832

GenBank Nucleotide #

NM_002814.3

NCBI Official Full Name

26S proteasome non-ATPase regulatory subunit 10 isoform 1

NCBI Official Synonym Full Names

proteasome 26S subunit, non-ATPase 10

NCBI Official Symbol

PSMD10

NCBI Official Synonym Symbols

p28; p28(GANK); dJ889N15.2

UniProt Protein Name

26S proteasome non-ATPase regulatory subunit 10

UniProt Synonym Protein Names

26S proteasome regulatory subunit p28; Gankyrin; p28(GANK)

Protein Family

26S proteasome non-ATPase regulatory

UniProt Gene Name

PSMD10

UniProt Entry Name

PSD10_HUMAN

NCBI Protein Information

26S proteasome non-ATPase regulatory subunit 10

NCBI Summary for PSMD10

This gene encodes a subunit of the PA700/19S complex, which is the regulatory component of the 26S proteasome. The 26S proteosome complex is required for ubiquitin-dependent protein degradation. This protein is a non-ATPase subunit that may be involved in protein-protein interactions. Aberrant expression of this gene may paly a role in tumorigenesis. Two transcripts encoding different isoforms have been described. Pseudogenes have been identified on chromosomes 3 and 20.[provided by RefSeq, Mar 2011]

UniProt Comments for PSMD10

Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pahway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis.

Research Articles on PSMD10

1. p28GANK expression was increased in metastatic ESCC tissues and cells, and p28GANK knockdown decreased the metastatic ability of ESCC cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PSMD10 recombinant protein

Reference Product	PubMed Publications
PSMC4 recombinant protein	>2 publications with PSMD10 and PSMC4
PSMC1 recombinant protein	>1 publications with PSMD10 and PSMC1

Pathways associated with PSMD10 recombinant protein

Products by Pathway	Pathway Diagram
APC/C-mediated Degradation Of Cell Cycle Proteins Pathway antibodies	APC/C-mediated Degradation Of Cell Cycle Proteins Pathway Diagram
APC/C:Cdc20 Mediated Degradation Of Securin Pathway antibodies	APC/C:Cdc20 Mediated Degradation Of Securin Pathway Diagram
APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway antibodies	APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway Diagram
APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway antibodies	APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway Diagram
APC:Cdc20 Mediated Degradation Of Cell Cycle Proteins Prior To Satisfation Of The Cell Cycle Checkpoint Pathway antibodies	APC:Cdc20 Mediated Degradation Of Cell Cycle Proteins Prior To Satisfation Of The Cell Cycle Checkpoint Pathway Diagram
ARMS-mediated Activation Pathway antibodies	ARMS-mediated Activation Pathway Diagram
AUF1 (hnRNP D0) Binds And Destabilizes MRNA Pathway antibodies	AUF1 (hnRNP D0) Binds And Destabilizes MRNA Pathway Diagram
Activation Of APC/C And APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway antibodies	Activation Of APC/C And APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway Diagram
Activation Of NF-kappaB In B Cells Pathway antibodies	Activation Of NF-kappaB In B Cells Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram

Diseases associated with PSMD10 recombinant protein

Disease Name	Pubmed Publications
Carcinoma, Hepatocellular Antibodies	>35 publications with PSMD10 and Carcinoma, Hepatocellular
Liver Diseases Antibodies	>33 publications with PSMD10 and Liver Diseases
Liver Neoplasms Antibodies	>31 publications with PSMD10 and Liver Neoplasms
Neoplasm Metastasis Antibodies	>17 publications with PSMD10 and Neoplasm Metastasis
Liver Cirrhosis Antibodies	>9 publications with PSMD10 and Liver Cirrhosis
Disease Models, Animal Antibodies	>9 publications with PSMD10 and Disease Models, Animal
Neoplasms, Experimental Antibodies	>8 publications with PSMD10 and Neoplasms, Experimental
Cell Transformation, Neoplastic Antibodies	>7 publications with PSMD10 and Cell Transformation, Neoplastic
Neoplasm Invasiveness Antibodies	>7 publications with PSMD10 and Neoplasm Invasiveness
Liver Neoplasms, Experimental Antibodies	>6 publications with PSMD10 and Liver Neoplasms, Experimental

Organs/Tissues associated with PSMD10 recombinant protein

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>42 publications with PSMD10 and Liver
Lymph Node Antibodies	>7 publications with PSMD10 and Lymph Node
Lymph Antibodies	>7 publications with PSMD10 and Lymph
Lung Antibodies	>5 publications with PSMD10 and Lung
Stomach Antibodies	>5 publications with PSMD10 and Stomach
Skin Antibodies	>3 publications with PSMD10 and Skin
Vascular Antibodies	>3 publications with PSMD10 and Vascular
Brain Antibodies	>3 publications with PSMD10 and Brain
Mouth Antibodies	>2 publications with PSMD10 and Mouth
Muscle Antibodies	>2 publications with PSMD10 and Muscle