Human AGPAT2 Recombinant Protein – Cat# MBS1113907

1-Acyl-Sn-Glycerol-3-Phosphate Acyltransferase Beta (AGPAT2) Human Recombinant Protein

Name: AGPAT2 Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1113907
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1113907

Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

1-acyl-sn-glycerol-3-phosphate acyltransferase beta (AGPAT2), Recombinant Protein

Full Product Name

Recombinant Human 1-acyl-sn-glycerol-3-phosphate acyltransferase beta (AGPAT2)

Product Gene Name

AGPAT2 recombinant protein

Product Synonym Gene Name

Recombinant 1-acyl-sn-glycerol-3-phosphate acyltransferase beta (AGPAT2); 1-acyl-sn-glycerol-3-phosphate acyltransferase beta EC= 2.3.1.51; 1-acylglycerol-3-phosphate O-acyltransferase 2; 1-AGP acyltransferase 2; 1-AGPAT 2 Lysophosphatidic acid acyltransferase beta; LPAAT-beta

Sequence

MELWPCLAAA LLLLLLLVQL SRAAEFYAKV ALYCALCFTV SAVASLVCLL RHGGRTVENM SIIGWFVRSF KYFYGLRFEV RDPRRLQEAR PCVIVSNHQS ILDMMGLMEV LPERCVQIAK RELLFLGPVG LIMYLGGVFF INRQRSSTAM TVMADLGERM VRENLKVWIY PEGTRNDNGD LLPFKKGAFY LAVQAQVPIV PVVYSSFSSF YNTKKKFFTS GTVTVQVLEA IPTSGLTAAD VPALVDTCHR AMRTTFLHIS KTPQENGATA GSGVQPAQ

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degree C. For extended storage, store at -20 or -80 degree C. Note: Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.

Molecular Weight

47kD

Sequence Positions

24-278

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

Chromosome Location

Chromosome: 9; NC_000009.11 (139567595..139581911, complement). Location: 9q34.3

OMIM

603100

3D Structure

ModBase 3D Structure for O15120

Species

Homo sapiens (Human)

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of AGPAT2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AGPAT2 purchase

MBS1113907 is a recombinant protein targeting AGPAT2. Also known as Recombinant Human 1-acyl-sn-glycerol-3-phosphate acyltransferase beta (AGPAT2). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for AGPAT2. It may not necessarily be applicable to this product.

NCBI GI #

69122971

NCBI GeneID

10555

NCBI Accession #

NP_001012745.1

UniProt Primary Accession #

O15120

UniProt Secondary Accession #

O00516; O15106; Q5VUD3; Q5VUD4; Q9BSV7; Q9BWR7

UniProt Related Accession #

O15120

GenBank Nucleotide #

NM_001012727.1

NCBI Official Full Name

1-acyl-sn-glycerol-3-phosphate acyltransferase beta isoform b

NCBI Official Synonym Full Names

1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)

NCBI Official Symbol

AGPAT2

NCBI Official Synonym Symbols

BSCL; BSCL1; LPAAB; 1-AGPAT2; LPAAT-beta

UniProt Protein Name

1-acyl-sn-glycerol-3-phosphate acyltransferase beta

UniProt Synonym Protein Names

1-acylglycerol-3-phosphate O-acyltransferase 2; 1-AGP acyltransferase 2; 1-AGPAT 2; Lysophosphatidic acid acyltransferase beta

Protein Family

1-acyl-sn-glycerol-3-phosphate acyltransferase

UniProt Gene Name

AGPAT2

UniProt Synonym Gene Names

1-AGP acyltransferase 2; 1-AGPAT 2; LPAAT-beta

UniProt Entry Name

PLCB_HUMAN

NCBI Protein Information

1-acyl-sn-glycerol-3-phosphate acyltransferase beta; 1-AGPAT 2; 1-AGP acyltransferase 2; lysophosphatidic acid acyltransferase beta; lysophosphatidic acid acyltransferase-beta; 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase-beta)

NCBI Summary for AGPAT2

This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. The protein is located within the endoplasmic reticulum membrane and converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. Mutations in this gene have been associated with congenital generalized lipodystrophy (CGL), or Berardinelli-Seip syndrome, a disease characterized by a near absence of adipose tissue and severe insulin resistance. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

UniProt Comments for AGPAT2

AGPAT2: Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Defects in AGPAT2 are the cause of congenital generalized lipodystrophy type 1 (CGL1); also known as Berardinelli-Seip congenital lipodystrophy type 1 (BSCL1) or Berardinelli-Seip syndrome. CGL1 is an autosomal recessive disorder characterized by marked paucity of adipose tissue, extreme insulin resistance, hypertriglyceridemia, hepatic steatosis and early onset of diabetes. Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.3.1.51; Lipid Metabolism - ether lipid; Membrane protein, multi-pass; Lipid Metabolism - glycerophospholipid; Membrane protein, integral; Lipid Metabolism - glycerolipid; Transferase

Chromosomal Location of Human Ortholog: 9q34.3

Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane

Molecular Function: 1-acylglycerol-3-phosphate O-acyltransferase activity

Biological Process: positive regulation of cytokine production; epidermis development; phospholipid metabolic process; glycerophospholipid biosynthetic process; phosphatidic acid biosynthetic process; triacylglycerol biosynthetic process; cellular lipid metabolic process; positive regulation of cytokine and chemokine mediated signaling pathway; CDP-diacylglycerol biosynthetic process

Disease: Lipodystrophy, Congenital Generalized, Type 1

Research Articles on AGPAT2

1. the role of AGPAT1 or AGPAT2 in liver lipogenesis is minimal and that accumulation of liver fat is primarily a consequence of insulin resistance

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with AGPAT2 recombinant protein

Products by Pathway	Pathway Diagram
Adipogenesis Pathway antibodies	Adipogenesis Pathway Diagram
CDP-diacylglycerol Biosynthesis I Pathway antibodies	CDP-diacylglycerol Biosynthesis I Pathway Diagram
CDP-diacylglycerol Biosynthesis I Pathway antibodies	CDP-diacylglycerol Biosynthesis I Pathway Diagram
Fat Digestion And Absorption Pathway antibodies	Fat Digestion And Absorption Pathway Diagram
Fat Digestion And Absorption Pathway antibodies	Fat Digestion And Absorption Pathway Diagram
Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies	Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
Glycerolipid Metabolism Pathway antibodies	Glycerolipid Metabolism Pathway Diagram
Glycerolipid Metabolism Pathway antibodies	Glycerolipid Metabolism Pathway Diagram
Glycerophospholipid Metabolism Pathway antibodies	Glycerophospholipid Metabolism Pathway Diagram
Glycerophospholipid Metabolism Pathway antibodies	Glycerophospholipid Metabolism Pathway Diagram

Diseases associated with AGPAT2 recombinant protein

Disease Name	Pubmed Publications
Skin Diseases Antibodies	>42 publications with AGPAT2 and Skin Diseases
LIPODYSTROPHY, CONGENITAL GENERALIZED, TYPE 1 Antibodies	>36 publications with AGPAT2 and LIPODYSTROPHY, CONGENITAL GENERALIZED, TYPE 1
Insulin Resistance Antibodies	>32 publications with AGPAT2 and Insulin Resistance
Liver Diseases Antibodies	>9 publications with AGPAT2 and Liver Diseases
Hypertrophy Antibodies	>9 publications with AGPAT2 and Hypertrophy
Congenital Abnormalities Antibodies	>8 publications with AGPAT2 and Congenital Abnormalities
Muscular Diseases Antibodies	>5 publications with AGPAT2 and Muscular Diseases
Hepatomegaly Antibodies	>4 publications with AGPAT2 and Hepatomegaly
Kidney Diseases Antibodies	>4 publications with AGPAT2 and Kidney Diseases
Fatty Liver Antibodies	>4 publications with AGPAT2 and Fatty Liver

Organs/Tissues associated with AGPAT2 recombinant protein

Organ/Tissue Name	Pubmed Publications
Adipose Tissue Antibodies	>33 publications with AGPAT2 and Adipose Tissue
Blood Antibodies	>12 publications with AGPAT2 and Blood
Connective Tissue Antibodies	>12 publications with AGPAT2 and Connective Tissue
Liver Antibodies	>11 publications with AGPAT2 and Liver
Muscle Antibodies	>8 publications with AGPAT2 and Muscle
Kidney Antibodies	>5 publications with AGPAT2 and Kidney
Bone Antibodies	>4 publications with AGPAT2 and Bone
Heart Antibodies	>3 publications with AGPAT2 and Heart
Brain Antibodies	>2 publications with AGPAT2 and Brain
Skin Antibodies	>2 publications with AGPAT2 and Skin