Drosophila Melanogaster fzo Recombinant Protein – Cat# MBS1116185

Transmembrane Gtpase Fzo (fzo) Drosophila Melanogaster Recombinant Protein

Name: fzo Recombinant Protein; Drosophila Melanogaster; MyBioSource
Brand: MyBioSource
SKU: MBS1116185
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1116185

MBS1116185 is a recombinant protein targeting fzo. Also known as Recombinant Drosophila melanogaster Transmembrane GTPase fzo (fzo). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

Please Inquire

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Transmembrane GTPase fzo (fzo), Recombinant Protein

Full Product Name

Recombinant Drosophila melanogaster Transmembrane GTPase fzo (fzo)

Product Gene Name

fzo recombinant protein

Product Synonym Gene Name

fzo; CG4568

Product Synonym Names

Recombinant Transmembrane GTPase fzo (fzo); Transmembrane GTPase fzo EC= 3.6.5.-; Protein fuzzy onions

Sequence

MAESDSGEST SSVSSFISSS SSSRLSEFVD AKTELQDIYH DLSNYLSNFL TILEETVLLK DRQMLEHLCA FSSRVEAIAK VLSRDRMKVA FFGRTSNGKS AVINALLHEK ILPSAMGHTT SCFCQVQANG SNETEHVKVE QEDEHMELSA LSQLASAHSP GALKPSTLLQ VNMAKNRCSI LDYDVVLMDT PGVDVTAQLD DCLDSYCMDA DVFILVLNAE STVSRVERQF FKDVASKLSR PNLFILNNRW DKASSLEPEM EQKVKDQHME RCVNLLVDEL GVYSTAQEAW ERIYHVSALE ALHIRNGQIT NPSGQTQQRY QEFLRFENDF SNCLAVSALK TKFGPHLLSA QKILNQLKST LICPFIEKVS RLIDENKERR ANLNAEIEDW LILMQEDREA LQYCFEELTE MTQRVGRCVL NDQIKTLIPS SVLSFSQPFH PEFPAQIGQY QRSLCAHLDK LLEDRVLQCL SIPLQRKILD IEKEIGLPIA ENSCDWQLIY GLDCQSYMSD FQPDLRFRFS LGFTALWHRL EGNLPLHASP FRIQKLQNGH KKCSPLPPLV NGNHWQMLES LVKSKGSLGT VLLSAMAIRS FNWPIVLILG GLVGSFYIYE YAAWTTAAQE RSFKSQYARL LQQRLRSDVQ QTVSGFELQL RQHLATVRNC WEAQSNETLN DLNVRTAELT KQIQSMEVLQ LSLKKFRDKG QLLASRLGDF QETYLTKS

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

Molecular Weight

81,565 Da

Sequence Positions

1-718

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

Chromosome Location

Chromosome: 3R; NT_033777.2 (19027366..19029756, complement). Location: 94E6-94E6

3D Structure

ModBase 3D Structure for O18412

Species

Drosophila melanogaster (Fruit fly)

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of fzo recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for fzo. It may not necessarily be applicable to this product.

NCBI GI #

24649250

NCBI GeneID

42745

NCBI Accession #

NP_732840.1

UniProt Primary Accession #

O18412

UniProt Secondary Accession #

Q4V3Y6; Q9VCP7

UniProt Related Accession #

O18412

GenBank Nucleotide #

NM_170060.2

NCBI Official Full Name

fuzzy onions

NCBI Official Synonym Full Names

fuzzy onions

NCBI Official Symbol

fzo

NCBI Official Synonym Symbols

anon-WO0125274.1; anon-WO0125274.25; anon-WO0125274.26; CG4568; DmelCG4568

UniProt Protein Name

Transmembrane GTPase fzo

UniProt Synonym Protein Names

Protein fuzzy onions

Protein Family

Transmembrane GTPase

UniProt Gene Name

fzo

UniProt Entry Name

FZO_DROME

NCBI Protein Information

CG4568 gene product from transcript CG4568-RA; CG4568-PA; fuzzy onions; fzo-PA

UniProt Comments for fzo

Function: Essential transmembrane GTPase, which mediates mitochondrial fusion during spermatogenesis. In early spermatocytes, fusion of mitochondria give rise to two organelles named Nebenkern and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. Essential for fertility. Ref.1

Catalytic activity: GTP + H2O = GDP + phosphate.

Subcellular location: Mitochondrion outer membrane; Multi-pass membrane protein Ref.1.

Tissue specificity: Specifically expressed in male germ cells, in spermatocytes and early spermatids. Not expressed in other tissues. Ref.1 Ref.5

Developmental stage: Associated with mitochondria in spermatids during a narrow developmental window. Mitochondria align on the spindle equator throughout meiotic divisions, but it is not expressed on mitochondria until the last of meiosis II. In postmeiotic haploid spermatids, it is associated with aggregating mitochondria and highly expressed on onion stage Nebenkerns. Expressed at lower levels associated with early elongation stage mitochondrial derivatives. Not detected on more elongated mitochondria.

Sequence similarities: Belongs to the mitofusin family.

Research Articles on fzo

1. expression of fzo was tightly restricted to the male germ line, with mRNA accumulation in spermatocytes and early spermatids

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.