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Cholecystokinin Receptor Type A (CCKAR) Rat Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1116440

MBS1116440 is a recombinant protein targeting Cckar. Also known as Recombinant Rat Cholecystokinin receptor type A (Cckar). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Cholecystokinin receptor type A (Cckar), Recombinant Protein
Full Product Name
Recombinant Rat Cholecystokinin receptor type A (Cckar)
Product Gene Name
Cckar recombinant protein
Product Synonym Gene Name
Cckar
Product Synonym Names
Recombinant Cholecystokinin receptor type A (Cckar); Cholecystokinin receptor type A; CCK-A receptor; CCK-AR; Cholecystokinin-1 receptor; CCK1-R
Sequence
MSHSPARQHL VESSRMDVVD SLLMNGSNIT PPCELGLENE TLFCLDQPQP SKEWQSALQI LLYSIIFLLS VLGNTLVITV LIRNKRMRTV TNIFLLSLAV SDLMLCLFCM PFNLIPNLLK DFIFGSAVCK TTTYFMGTSV SVSTFNLVAI SLERYGAICR PLQSRVWQTK SHALKVIAAT WCLSFTIMTP YPIYSNLVPF TKNNNQTANM CRFLLPSDAM QQSWQTFLLL ILFLLPGIVM VVAYGLISLE LYQGIKFDAS QKKSAKEKKP STGSSTRYED SDGCYLQKSR PPRKLELQQL SSGSGGSRLN RIRSSSSAAN LIAKKRVIRM LIVIVVLFFL CWMPIFSANA WRAYDTVSAE KHLSGTPISF ILLLSYTSSC VNPIIYCFMN KRFRLGFMAT FPCCPNPGPP GVRGEVGEEE DGRTIRALLS RYSYSHMSTS APPP
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
Molecular Weight
49,657 Da
Sequence Positions
1-444
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Chromosome Location
Chromosome: 14; NC_005113.3 (59738043..59746392). Location: 14q11
3D Structure
ModBase 3D Structure for P30551
Species
Rattus norvegicus (Rat)
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Cckar recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Cckar. It may not necessarily be applicable to this product.

NCBI GI #
6978615
NCBI GeneID
24889
NCBI Accession #
NP_036820.1
UniProt Primary Accession #
P30551
UniProt Related Accession #
P30551
GenBank Nucleotide #
NM_012688.3
NCBI Official Full Name
cholecystokinin receptor type A
NCBI Official Synonym Full Names
cholecystokinin A receptor
NCBI Official Symbol
Cckar
NCBI Official Synonym Symbols
Cck-ar
UniProt Protein Name
Cholecystokinin receptor type A
UniProt Synonym Protein Names
Cholecystokinin-1 receptor
Protein Family
Cholecystokinin receptor
UniProt Gene Name
Cckar
UniProt Synonym Gene Names
CCK-A receptor; CCK-AR; CCK1-R
UniProt Entry Name
CCKAR_RAT
NCBI Protein Information
cholecystokinin receptor type A; CCK1-R; CCK-A receptor; cholecystokinin-1 receptor

NCBI Summary for Cckar

G-protein coupled receptor activated by cholecystokinin; may be involved in food intake and insulin regulation [RGD, Feb 2006]

UniProt Comments for Cckar

CCKAR: Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR

Cellular Component: integral to plasma membrane; lysosome; endoplasmic reticulum; cytoplasm; integral to membrane; plasma membrane; terminal button; endosome

Molecular Function: cholecystokinin receptor activity; peptide binding

Biological Process: gastric acid secretion; organ regeneration; regulation of potassium ion transport; eating behavior; response to glucocorticoid stimulus; regulation of hormone secretion; neuron migration; response to lipopolysaccharide; regulation of calcium ion transport; thermoregulation; pancreatic juice secretion; reduction of food intake in response to dietary excess; cellular response to hormone stimulus; response to starvation; response to radiation; elevation of cytosolic calcium ion concentration; axonogenesis; response to heat; insulin secretion; response to steroid hormone stimulus; actin cytoskeleton reorganization; pancreas development; forebrain development; feeding behavior; response to nutrient
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Research Articles on Cckar

1. Activation of duodenal PKC-delta leads to the stimulation of CCK release and activation of the CCK-A receptor signaling axis to lower glucose production in normal rats.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Cckar recombinant protein

 Reference Product  PubMed Publications
 Cck recombinant protein  >36 publications with Cckar and Cck
 Cckbr recombinant protein  >15 publications with Cckar and Cckbr
 Fos recombinant protein  >2 publications with Cckar and Fos
 Cd38 recombinant protein  >1 publications with Cckar and Cd38

Pathways associated with Cckar recombinant protein

 Products by Pathway  Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Insulin Secretion Pathway antibodies  Insulin Secretion Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Pancreatic Secretion Pathway antibodies  Pancreatic Secretion Pathway Diagram
 Pancreatic Secretion Pathway antibodies  Pancreatic Secretion Pathway Diagram
 Peptide GPCRs Pathway antibodies  Peptide GPCRs Pathway Diagram

Diseases associated with Cckar recombinant protein

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >6 publications with Cckar and Nervous System Diseases
 Brain Diseases Antibodies  >5 publications with Cckar and Brain Diseases
 Disease Models, Animal Antibodies  >4 publications with Cckar and Disease Models, Animal
 Hyperglycemia Antibodies  >3 publications with Cckar and Hyperglycemia
 Syndrome Antibodies  >3 publications with Cckar and Syndrome
 Insulin Resistance Antibodies  >2 publications with Cckar and Insulin Resistance
 Alcoholism Antibodies  >2 publications with Cckar and Alcoholism
 Liver Diseases Antibodies  >1 publications with Cckar and Liver Diseases
 Inflammation Antibodies  >1 publications with Cckar and Inflammation
 Hyperplasia Antibodies  >1 publications with Cckar and Hyperplasia
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