Mouse BRD7 Recombinant Protein – Cat# MBS1120084

Bromodomain-Containing Protein 7 (BRD7) Mouse Recombinant Protein

Name: BRD7 Recombinant Protein; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS1120084
Price: 1465 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1120084

MBS1120084 is a recombinant protein targeting Brd7. Also known as Recombinant Mouse Bromodomain-containing protein 7 (Brd7). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$1465 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Bromodomain-containing protein 7 (Brd7), Recombinant Protein

Full Product Name

Recombinant Mouse Bromodomain-containing protein 7 (Brd7)

Product Gene Name

Brd7 recombinant protein

Sequence

MGKKHKKHKS DRHFYEEYVE KPLKLVLKVG GSEVTELSTG SSGHDSSLFE DRSDHDKHKD RKRKKRKKGE KQAPGEEKGR KRRRVKEDKK KRDRDRAENE VDRDLQCHVP IRLDLPPEKP LTSSLAKQEE VEQTPLQEAL NQLMRQLQRK DPSAFFSFPV TDFIAPGYSM IIKHPMDFST MKEKIKNNDY QSIEELKDNF KLMCTNAMIY NKPETIYYKA AKKLLHSGMK ILSQERIQSL KQSIDFMSDL QKTRKQKERT DACQSGEDSG CWQREREDSG DAETQAFRSP AKDNKRKDKD VLEDKWRSSN SEREHEQIER VVQESGGKLT RRLANSQCEF ERRKPDGTTT LGLLHPVDPI VGEPGYCPVR LGMTTGRLQS GVNTLQGFKE DKRNRVTPVL YLNYGPYSSY APHYDSTFAN ISKDDSDLIY STYGEDSDLP NNFSISEFLA TCQDYPYVMA DSLLDVLTKG GHSRSLQDLD MSSPEDEGQT RALDTAKEAE ITQIEPTGRL ESSSQDRLTA LQAVTTFGAP AEVFDSEEAE VFQRKLDETT RLLRELQEAQ NERLSTRPPP NMICLLGPSY REMYLAEQVT NNLKELTQQV TPGDVVSIHG VRKAMGISVP SPIVGNSFVD LTGECEEPKE TSTAECGPDA S

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

74,000 Da

Sequence Positions

1-651, Full length protein

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

3D Structure

ModBase 3D Structure for O88665

Species

Mouse

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Brd7 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Brd7. It may not necessarily be applicable to this product.

NCBI GI #

6755234

NCBI GeneID

26992

NCBI Accession #

NP_036177.1

UniProt Primary Accession #

O88665

UniProt Secondary Accession #

Q3UQ56; Q3UU06; Q9CT78

UniProt Related Accession #

O88665

GenBank Nucleotide #

NM_012047.2

NCBI Official Full Name

bromodomain-containing protein 7

NCBI Official Synonym Full Names

bromodomain containing 7

NCBI Official Symbol

Brd7

NCBI Official Synonym Symbols

BP75; CELTIX1; Ptpn13ip

UniProt Protein Name

Bromodomain-containing protein 7

UniProt Synonym Protein Names

75 kDa bromodomain protein

Protein Family

Bromodomain-containing protein

UniProt Gene Name

Brd7

UniProt Synonym Gene Names

Bp75

NCBI Protein Information

bromodomain-containing protein 7

UniProt Comments for Brd7

Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase (). Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR.

Research Articles on Brd7

1. Furthermore, Brd7 inhibition alters the phenotype of macrophages and promotes plaque instability, at least partly via STAT6 signaling. Our data define a previously undescribed role of Brd7 in the development of atherosclerosis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Brd7 recombinant protein

Reference Product	PubMed Publications
Myc recombinant protein	>4 publications with Brd7 and Myc
Trp53 recombinant protein	>4 publications with Brd7 and Trp53
E2f6 recombinant protein	>2 publications with Brd7 and E2f6
Ptpn13 recombinant protein	>1 publications with Brd7 and Ptpn13
Irf2 recombinant protein	>1 publications with Brd7 and Irf2
Prmt5 recombinant protein	>1 publications with Brd7 and Prmt5

Pathways associated with Brd7 recombinant protein

Products by Pathway	Pathway Diagram
Wnt Signaling Pathway NetPath antibodies	Wnt Signaling Pathway NetPath Diagram
XPodNet - Protein-protein Interactions In The Podocyte Expanded By STRING Pathway antibodies	XPodNet - Protein-protein Interactions In The Podocyte Expanded By STRING Pathway Diagram

Diseases associated with Brd7 recombinant protein

Disease Name	Pubmed Publications
Neoplasm Metastasis Antibodies	>2 publications with Brd7 and Neoplasm Metastasis
Prostatic Neoplasms Antibodies	>1 publications with Brd7 and Prostatic Neoplasms
Ovarian Neoplasms Antibodies	>1 publications with Brd7 and Ovarian Neoplasms
Abnormalities, Multiple Antibodies	>1 publications with Brd7 and Abnormalities, Multiple
Nervous System Diseases Antibodies	>1 publications with Brd7 and Nervous System Diseases
Neoplasms, Experimental Antibodies	>1 publications with Brd7 and Neoplasms, Experimental
Genital Diseases, Male Antibodies	>1 publications with Brd7 and Genital Diseases, Male
Prostatic Diseases Antibodies	>1 publications with Brd7 and Prostatic Diseases
Disease Models, Animal Antibodies	>1 publications with Brd7 and Disease Models, Animal

Organs/Tissues associated with Brd7 recombinant protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>5 publications with Brd7 and Brain
Lung Antibodies	>4 publications with Brd7 and Lung
Bone Antibodies	>3 publications with Brd7 and Bone
Lymph Node Antibodies	>2 publications with Brd7 and Lymph Node
Liver Antibodies	>2 publications with Brd7 and Liver
Thyroid Antibodies	>2 publications with Brd7 and Thyroid
Stomach Antibodies	>2 publications with Brd7 and Stomach
Blood Antibodies	>2 publications with Brd7 and Blood
Bone Marrow Antibodies	>1 publications with Brd7 and Bone Marrow
Kidney Antibodies	>1 publications with Brd7 and Kidney