Human CCN1 Recombinant Protein – Cat# MBS1123771

CCN Family Member 1 (CCN1) Human Recombinant Protein

Name: CCN1 Recombinant Protein; CCN Family Member 1; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1123771
Price: 315 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1123771

Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including… More details

$315 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CCN family member 1 (CCN1), Recombinant Protein

Full Product Name

Recombinant Human CCN family member 1 (CCN1)

Product Gene Name

CCN1 recombinant protein

Product Synonym Names

CCN family member 1; Cysteine-rich angiogenic inducer 61; Insulin-like growth factor-binding protein 10; IBP-10; IGF-binding protein 10; IGFBP-10; Protein GIG1

Sequence

TCPAACHCPL EAPKCAPGVG LVRDGCGCCK VCAKQLNEDC SKTQPCDHTK GLECNFGASS TALKGICRAQ SEGRPCEYNS RIYQNGESFQ PNCKHQCTCI DGAVGCIPLC PQELSLPNLG CPNPRLVKVT GQCCEEWVCD EDSIKDPMED QDGLLGKELG FDASEVELTR NNELIAVGKG SSLKRLPVFG MEPRILYNPL QGQKCIVQTT SWSQCSKTCG TGISTRVTND NPECRLVKET RICEVRPCGQ PVYSSLKKGK KCSKTKKSPE PVRFTYAGCL SVKKYRPKYC GSCVDGRCCT PQLTRTVKMR FRCEDGETFS KNVMMIQSCK CNYNCPHANE AAFPFYRLFN DIHKFRD

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

Molecular Weight

55.4 kDa

Sequence Positions

25-381aa; Full Length of Mature Protein

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

602369

3D Structure

ModBase 3D Structure for O00622

Species

Homo sapiens (Human)

Production Note

Special Offer: The E Coli host-expressed protein is manufactured from a stock plasmid containing the protein gene. E Colihost-expressed protein is stocked in different unit sizes ranging from as small as 10 ug to as large as 1 mg. Bulk inventory is also available. The E Coli host-expressed protein has been ordered over and over again by researchers and has stood the test of time as both a robust protein and important target for the research community. It is part of our new program to make our most popular protein targets and corresponding hosts available in expanded unit sizes and with a quick processing time. Select E Coli host-expressed protein for the fastest delivery among all hosts. Please contact our technical support team or email to support@mybiosource.com for more details.

Product Categories/Family for CCN1 recombinant protein

Stem Cells

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Product References and Citations for CCN1 recombinant protein

"The angiogenic factor Cyr61 activates a genetic program for wound healing in human skin fibroblasts." Chen C.-C., Mo F.-E., Lau L.F. J. Biol. Chem. 276:47329-47337(2001)

Other Notes

Small volumes of CCN1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CCN1 purchase

MBS1123771 is a recombinant protein targeting CCN1. Also known as Recombinant Human CCN family member 1 (CCN1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for CCN1. It may not necessarily be applicable to this product.

NCBI GI #

31542331

NCBI GeneID

3491

NCBI Accession #

NP_001545.2

UniProt Primary Accession #

O00622

UniProt Secondary Accession #

O14934; O43775; Q9BZL7

UniProt Related Accession #

O00622

GenBank Nucleotide #

NM_001554.4

NCBI Official Full Name

protein CYR61

NCBI Official Synonym Full Names

cysteine rich angiogenic inducer 61

NCBI Official Symbol

CYR61

NCBI Official Synonym Symbols

CCN1; GIG1; IGFBP10

UniProt Protein Name

Protein CYR61

UniProt Synonym Protein Names

CCN family member 1; Cysteine-rich angiogenic inducer 61; Insulin-like growth factor-binding protein 10; IBP-10; IGF-binding protein 10; IGFBP-10; Protein GIG1

Protein Family

G1/S-specific cyclin

UniProt Gene Name

CYR61

UniProt Synonym Gene Names

CCN1; GIG1; IGFBP10; IBP-10; IGF-binding protein 10; IGFBP-10

UniProt Entry Name

CYR61_HUMAN

NCBI Protein Information

protein CYR61

NCBI Summary for CCN1

The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation. [provided by RefSeq, Sep 2011]

UniProt Comments for CCN1

CYR61: Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3. Belongs to the CCN family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 1p22.3

Cellular Component: extracellular matrix; proteinaceous extracellular matrix

Molecular Function: extracellular matrix binding; heparin binding; insulin-like growth factor binding; integrin binding

Biological Process: anatomical structure morphogenesis; cell adhesion; cell proliferation; cell-cell signaling; chemotaxis; extracellular matrix organization and biogenesis; intussusceptive angiogenesis; negative regulation of apoptosis; osteoblast differentiation; positive regulation of BMP signaling pathway; positive regulation of caspase activity; positive regulation of cell migration; positive regulation of osteoblast differentiation; positive regulation of osteoblast proliferation; positive regulation of protein amino acid phosphorylation; positive regulation of protein kinase activity; positive regulation of transcription from RNA polymerase II promoter; regulation of cell growth; signal transduction

Research Articles on CCN1

1. Overexpression of Cyr61 may induce epithelial-mesenchymal transition and therefore leads to laryngeal squamous- cell carcinoma invasion and metastasis and poor prognosis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CCN1 recombinant protein

Reference Product	PubMed Publications
JUN recombinant protein	>93 publications with CCN1 and JUN
FOS recombinant protein	>20 publications with CCN1 and FOS
CTNNB1 recombinant protein	>14 publications with CCN1 and CTNNB1
RHOA recombinant protein	>10 publications with CCN1 and RHOA
SRF recombinant protein	>6 publications with CCN1 and SRF
MKL1 recombinant protein	>6 publications with CCN1 and MKL1
ITGAV recombinant protein	>1 publications with CCN1 and ITGAV

Pathways associated with CCN1 recombinant protein

Products by Pathway	Pathway Diagram
Hypertrophy Model Pathway antibodies	Hypertrophy Model Pathway Diagram
Oncostatin M Signaling Pathway antibodies	Oncostatin M Signaling Pathway Diagram
Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway antibodies	Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway Diagram
RhoA Signaling Pathway antibodies	RhoA Signaling Pathway Diagram
Amb2 Integrin Signaling Pathway antibodies	Amb2 Integrin Signaling Pathway Diagram

Diseases associated with CCN1 recombinant protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>63 publications with CCN1 and Inflammation
Disease Models, Animal Antibodies	>49 publications with CCN1 and Disease Models, Animal
Neoplasm Metastasis Antibodies	>49 publications with CCN1 and Neoplasm Metastasis
Breast Neoplasms Antibodies	>45 publications with CCN1 and Breast Neoplasms
Fibrosis Antibodies	>40 publications with CCN1 and Fibrosis
Nervous System Diseases Antibodies	>31 publications with CCN1 and Nervous System Diseases
Necrosis Antibodies	>26 publications with CCN1 and Necrosis
Brain Diseases Antibodies	>23 publications with CCN1 and Brain Diseases
Lung Neoplasms Antibodies	>23 publications with CCN1 and Lung Neoplasms
Hyperplasia Antibodies	>21 publications with CCN1 and Hyperplasia

Organs/Tissues associated with CCN1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Connective Tissue Antibodies	>189 publications with CCN1 and Connective Tissue
Vascular Antibodies	>139 publications with CCN1 and Vascular
Bone Antibodies	>86 publications with CCN1 and Bone
Muscle Antibodies	>82 publications with CCN1 and Muscle
Embryonic Tissue Antibodies	>57 publications with CCN1 and Embryonic Tissue
Lung Antibodies	>52 publications with CCN1 and Lung
Brain Antibodies	>39 publications with CCN1 and Brain
Prostate Antibodies	>34 publications with CCN1 and Prostate
Skin Antibodies	>33 publications with CCN1 and Skin
Liver Antibodies	>31 publications with CCN1 and Liver