Frizzled-3 (fz3) Drosophila Melanogaster Recombinant Protein

Function: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Required to coordinate the cytoskeletons of epidermal cells to produce a parallel array of cuticular hairs and bristles. Ref.1 Ref.2

Subcellular location: Membrane; Multi-pass membrane protein

Potential.

Tissue specificity: Wing, leg and eye imaginal disks. In embryos, expressed is seen in brain, proventriculus, Malpighian tubules, anal plate and visceral mesoderm of parasegment 8.

Developmental stage: Expressed in embryos from stage 11 and in larvae.

Domain: The FZ domain is involved in binding with Wnt ligands

By similarity.

Sequence similarities: Belongs to the G-protein coupled receptor Fz/Smo family.Contains 1 FZ (frizzled) domain.

Sequence caution: The sequence CAA20896.1 differs from that shown. Reason: Erroneous gene model prediction.