Mitochondrial Import Inner Membrane Translocase Subunit TIM21 (TIM21) Saccharomyces Cerevisiae Recombinant Protein

Function: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to keep the TOM and the TIM23 complexes in close contact. At some point, it is released from the TOM23 complex to allow protein translocation into the mitochondrial matrix. In the complex, it acts as an antagonist of TIM50 by reducing preprotein accumulation at the TOM23 complex and promotes dissociation of the PAM complex from the TIM23 complex. Ref.7 Ref.8

Subunit structure: Component of the TIM23 complex, at least composed of TIM23, TIM17, TIM50 and TIM21. Interacts directly with TIM23. Interacts with TOM22 component of the TOM complex. Released from the TOM23 complex by the PAM complex, leading to protein translocation into the mitochondrial matrix. Ref.7 Ref.8

Subcellular location: Mitochondrion inner membrane; Single-pass membrane protein Ref.5 Ref.7.

Miscellaneous: Present with 3770 molecules/cell in log phase SD medium.

Sequence similarities: Belongs to the TIM21 family.