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Semaphorin-7a (SEMA7A) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1130468

MBS1130468 is a recombinant protein targeting SEMA7A. Also known as Recombinant Human Semaphorin-7A (SEMA7A). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$545 / 0.02 mg (Baculovirus) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Semaphorin-7A (SEMA7A), Recombinant Protein
Full Product Name
Recombinant Human Semaphorin-7A (SEMA7A)
Sequence
QGHLRSGPRI FAVWKGHVGQ DRVDFGQTEP HTVLFHEPGS SSVWVGGRGK VYLFDFPEGK NASVRTVNIG STKGSCLDKR DCENYITLLE RRSEGLLACG TNARHPSCWN LVNGTVVPLG EMRGYAPFSP DENSLVLFEG DEVYSTIRKQ EYNGKIPRFR RIRGESELYT SDTVMQNPQF IKATIVHQDQ AYDDKIYYFF REDNPDKNPE APLNVSRVAQ LCRGDQGGES SLSVSKWNTF LKAMLVCSDA ATNKNFNRLQ DVFLLPDPSG QWRDTRVYGV FSNPWNYSAV CVYSLGDIDK VFRTSSLKGY HSSLPNPRPG KCLPDQQPIP TETFQVADRH PEVAQRVEPM GPLKTPLFHS KYHYQKVAVH RMQASHGETF HVLYLTTDRG TIHKVVEPGE QEHSFAFNIM EIQPFRRAAA IQTMSLDAER RKLYVSSQWE VSQVPLDLCE VYGGGCHGCL MSRDPYCGWD QGRCISIYSS ERSVLQSINP AEPHKECPNP KPDKAPLQKV SLAPNSRYYL SCPMESRHAT YSWRHKENVE QSCEPGHQSP NCILFIENLT AQQYGHYFCE AQEGSYFREA QHWQLLPEDG IMAEHLLGHA CALA
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
70.4 kDa
Sequence Positions
45-648aa; Full Length of Mature Protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
607961
3D Structure
ModBase 3D Structure for O75326
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of SEMA7A recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SEMA7A. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
semaphorin-7A isoform 2
NCBI Official Synonym Full Names
semaphorin 7A (John Milton Hagen blood group)
NCBI Official Symbol
SEMA7A
NCBI Official Synonym Symbols
JMH; CD108; SEMAL; CDw108; SEMAK1; H-Sema-L; H-SEMA-K1
UniProt Protein Name
Semaphorin-7A
UniProt Synonym Protein Names
CDw108; JMH blood group antigen; John-Milton-Hargen human blood group Ag; Semaphorin-K1; Sema K1; Semaphorin-L; Sema L; CD_antigen: CD108
Protein Family
UniProt Gene Name
SEMA7A
UniProt Synonym Gene Names
CD108; SEMAL; Sema K1; Sema L
NCBI Protein Information
semaphorin-7A

NCBI Summary for SEMA7A

This gene encodes a member of the semaphorin family of proteins. The encoded preproprotein is proteolytically processed to generate the mature glycosylphosphatidylinositol (GPI)-anchored membrane glycoprotein. The encoded protein is found on activated lymphocytes and erythrocytes and may be involved in immunomodulatory and neuronal processes. The encoded protein carries the John Milton Hagen (JMH) blood group antigens. Mutations in this gene may be associated with reduced bone mineral density (BMD). Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
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UniProt Comments for SEMA7A

Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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